JP2609183B2 - リポソーム製剤 - Google Patents
リポソーム製剤Info
- Publication number
- JP2609183B2 JP2609183B2 JP3199794A JP19979491A JP2609183B2 JP 2609183 B2 JP2609183 B2 JP 2609183B2 JP 3199794 A JP3199794 A JP 3199794A JP 19979491 A JP19979491 A JP 19979491A JP 2609183 B2 JP2609183 B2 JP 2609183B2
- Authority
- JP
- Japan
- Prior art keywords
- liposome
- drug
- cholesterol
- neutral
- dispersion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- 229940079593 drug Drugs 0.000 claims abstract description 52
- 239000012528 membrane Substances 0.000 claims abstract description 34
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- -1 anionic phospholipid Chemical class 0.000 claims abstract description 15
- 235000012000 cholesterol Nutrition 0.000 claims abstract description 10
- 150000001768 cations Chemical group 0.000 claims abstract description 9
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- 239000003792 electrolyte Substances 0.000 claims description 8
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- 239000002253 acid Substances 0.000 claims description 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 2
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- BPHQZTVXXXJVHI-AJQTZOPKSA-N ditetradecanoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCCCCCCCC BPHQZTVXXXJVHI-AJQTZOPKSA-N 0.000 description 3
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- 210000004881 tumor cell Anatomy 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Formation And Processing Of Food Products (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3199794A JP2609183B2 (ja) | 1990-07-16 | 1991-07-16 | リポソーム製剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2-187370 | 1990-07-16 | ||
| JP18737090 | 1990-07-16 | ||
| JP3199794A JP2609183B2 (ja) | 1990-07-16 | 1991-07-16 | リポソーム製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH05194191A JPH05194191A (ja) | 1993-08-03 |
| JP2609183B2 true JP2609183B2 (ja) | 1997-05-14 |
Family
ID=16204819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3199794A Expired - Fee Related JP2609183B2 (ja) | 1990-07-16 | 1991-07-16 | リポソーム製剤 |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0467275B1 (enExample) |
| JP (1) | JP2609183B2 (enExample) |
| KR (1) | KR100223129B1 (enExample) |
| AT (1) | ATE144415T1 (enExample) |
| CA (1) | CA2046997C (enExample) |
| DE (1) | DE69122810T2 (enExample) |
| DK (1) | DK0467275T3 (enExample) |
| ES (1) | ES2097168T3 (enExample) |
| GR (1) | GR3021982T3 (enExample) |
| HU (1) | HU211991A9 (enExample) |
| TW (1) | TW205510B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2041597B1 (es) * | 1992-05-05 | 1994-06-01 | Bazaco Joan Freixas | Nuevo procedimiento para la preparacion de liposomas que encapsulan productos farmaceuticos y cosmeticos. |
| US5464696A (en) * | 1992-08-13 | 1995-11-07 | Bracco International B.V. | Particles for NMR imaging |
| CA2120197A1 (en) * | 1993-04-02 | 1994-10-03 | Kenji Endo | Stable aqueous dispersions containing liposomes |
| FI961893A0 (fi) * | 1993-11-04 | 1996-05-03 | Schering Ag | Varautunut liposomivalmiste |
| DE19639811A1 (de) * | 1996-09-27 | 1998-04-02 | Artur Herzog Dr Mesmer | Verwendung einer Liposomenlösung zur Verstärkung der Wirksamkeit und/oder Verminderung der Toxizität von Arzneimitteln |
| CA2376849C (en) * | 1999-06-24 | 2008-10-14 | Kyowa Hakko Kogyo Co., Ltd. | Method of inhibiting leakage of drug encapsulated in liposomes |
| EP1585504A4 (en) * | 2002-11-06 | 2009-07-15 | Azaya Therapeutics Inc | Protein stabilized liposomal formulations of pharmaceutical active ingredients |
| KR100965088B1 (ko) * | 2004-12-07 | 2010-06-23 | (주)아모레퍼시픽 | 유효성분의 안정화를 위한 다층 라멜라 베지클 및 그제조방법 |
| GR20060100144A (el) * | 2006-03-03 | 2007-10-17 | Θεραπεια του καρκινου με χρηση οξαλιπλατινης εγκλεισμενης μεσα σε λιποσωματα και απο κοινου εγκλεισμος στο λιποσωμιακο μοριο περισσοτερων απο ενος φαρμακευτικου παρασκευασματος h gene | |
| ES2325901B1 (es) * | 2008-02-20 | 2010-07-06 | Heber Farma Sl | Vehiculizacion del factor de crecimiento epidermico a traves de biomembranas. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4419348A (en) * | 1981-04-27 | 1983-12-06 | Georgetown University | Anthracycline glycoside compositions, their use and preparation |
| IE58981B1 (en) * | 1985-10-15 | 1993-12-15 | Vestar Inc | Anthracycline antineoplastic agents encapsulated in phospholipid micellular particles |
| JPH0617309B2 (ja) * | 1985-11-29 | 1994-03-09 | 株式会社ビタミン研究所 | アドリアマイシン包埋リポソ−ム製剤 |
| US4797285A (en) * | 1985-12-06 | 1989-01-10 | Yissum Research And Development Company Of The Hebrew University Of Jerusalem | Lipsome/anthraquinone drug composition and method |
| IL97538A (en) * | 1986-12-23 | 1995-03-15 | Liposome Co Inc | Multilamellar liposomes containing nonphosphate guanindino aminoglycosides and their preparation. |
-
1991
- 1991-07-12 CA CA002046997A patent/CA2046997C/en not_active Expired - Fee Related
- 1991-07-15 TW TW080105474A patent/TW205510B/zh active
- 1991-07-15 DE DE69122810T patent/DE69122810T2/de not_active Expired - Fee Related
- 1991-07-15 AT AT91111795T patent/ATE144415T1/de not_active IP Right Cessation
- 1991-07-15 EP EP91111795A patent/EP0467275B1/en not_active Expired - Lifetime
- 1991-07-15 ES ES91111795T patent/ES2097168T3/es not_active Expired - Lifetime
- 1991-07-15 DK DK91111795.0T patent/DK0467275T3/da active
- 1991-07-16 KR KR1019910012144A patent/KR100223129B1/ko not_active Expired - Fee Related
- 1991-07-16 JP JP3199794A patent/JP2609183B2/ja not_active Expired - Fee Related
-
1995
- 1995-06-22 HU HU95P/P00406P patent/HU211991A9/hu unknown
-
1996
- 1996-12-11 GR GR960403415T patent/GR3021982T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2046997A1 (en) | 1992-01-17 |
| EP0467275A1 (en) | 1992-01-22 |
| JPH05194191A (ja) | 1993-08-03 |
| TW205510B (enExample) | 1993-05-11 |
| EP0467275B1 (en) | 1996-10-23 |
| DK0467275T3 (enExample) | 1997-02-17 |
| DE69122810D1 (de) | 1996-11-28 |
| ES2097168T3 (es) | 1997-04-01 |
| HU211991A9 (en) | 1996-01-29 |
| DE69122810T2 (de) | 1997-05-28 |
| KR100223129B1 (ko) | 1999-10-15 |
| ATE144415T1 (de) | 1996-11-15 |
| KR920002165A (ko) | 1992-02-28 |
| CA2046997C (en) | 2000-12-12 |
| GR3021982T3 (en) | 1997-03-31 |
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