JP2026016787A5 - - Google Patents
Info
- Publication number
- JP2026016787A5 JP2026016787A5 JP2025188198A JP2025188198A JP2026016787A5 JP 2026016787 A5 JP2026016787 A5 JP 2026016787A5 JP 2025188198 A JP2025188198 A JP 2025188198A JP 2025188198 A JP2025188198 A JP 2025188198A JP 2026016787 A5 JP2026016787 A5 JP 2026016787A5
- Authority
- JP
- Japan
- Prior art keywords
- gene segments
- unrearranged
- gene
- human
- rearranged
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862685203P | 2018-06-14 | 2018-06-14 | |
| US62/685,203 | 2018-06-14 | ||
| US201862702206P | 2018-07-23 | 2018-07-23 | |
| US62/702,206 | 2018-07-23 | ||
| US201962812580P | 2019-03-01 | 2019-03-01 | |
| US62/812,580 | 2019-03-01 | ||
| JP2020569099A JP7182647B2 (ja) | 2018-06-14 | 2019-06-14 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| PCT/US2019/037285 WO2019241692A1 (en) | 2018-06-14 | 2019-06-14 | Non-human animals capable of dh-dh rearrangement in the immunoglobulin heavy chain coding sequences |
| JP2022056227A JP2022079617A (ja) | 2018-06-14 | 2022-03-30 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2023215643A JP2024019660A (ja) | 2018-06-14 | 2023-12-21 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2024100324A JP7815335B2 (ja) | 2018-06-14 | 2024-06-21 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024100324A Division JP7815335B2 (ja) | 2018-06-14 | 2024-06-21 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2026028161A Division JP2026069737A (ja) | 2018-06-14 | 2026-02-25 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2026016787A JP2026016787A (ja) | 2026-02-03 |
| JP2026016787A5 true JP2026016787A5 (https=) | 2026-03-05 |
Family
ID=67220854
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020569099A Active JP7182647B2 (ja) | 2018-06-14 | 2019-06-14 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2022056227A Withdrawn JP2022079617A (ja) | 2018-06-14 | 2022-03-30 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2023215643A Withdrawn JP2024019660A (ja) | 2018-06-14 | 2023-12-21 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2024100324A Active JP7815335B2 (ja) | 2018-06-14 | 2024-06-21 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2025188198A Pending JP2026016787A (ja) | 2018-06-14 | 2025-11-07 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020569099A Active JP7182647B2 (ja) | 2018-06-14 | 2019-06-14 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2022056227A Withdrawn JP2022079617A (ja) | 2018-06-14 | 2022-03-30 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2023215643A Withdrawn JP2024019660A (ja) | 2018-06-14 | 2023-12-21 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2024100324A Active JP7815335B2 (ja) | 2018-06-14 | 2024-06-21 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US20210251202A1 (https=) |
| EP (3) | EP3629720B1 (https=) |
| JP (5) | JP7182647B2 (https=) |
| KR (3) | KR102617284B1 (https=) |
| CN (2) | CN113430207A (https=) |
| AU (3) | AU2019287727B2 (https=) |
| CA (1) | CA3103646C (https=) |
| CY (1) | CY1125121T1 (https=) |
| DK (2) | DK4023059T3 (https=) |
| ES (2) | ES2994581T3 (https=) |
| FI (1) | FI4023059T3 (https=) |
| HR (2) | HRP20220509T8 (https=) |
| HU (1) | HUE069544T2 (https=) |
| IL (3) | IL318469A (https=) |
| LT (2) | LT3629720T (https=) |
| MX (2) | MX391767B (https=) |
| PL (2) | PL4023059T3 (https=) |
| PT (2) | PT4023059T (https=) |
| RS (2) | RS66298B1 (https=) |
| SG (1) | SG11202012084WA (https=) |
| SI (2) | SI3629720T1 (https=) |
| SM (2) | SMT202400501T1 (https=) |
| TW (2) | TWI840372B (https=) |
| WO (1) | WO2019241692A1 (https=) |
| ZA (1) | ZA202007560B (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3424947T (lt) | 2011-10-28 | 2021-03-10 | Regeneron Pharmaceuticals, Inc. | Genetiškai modifikuotos t ląstelių receptorių pelės |
| IL318469A (en) * | 2018-06-14 | 2025-03-01 | Regeneron Pharma | Non-human animals capable of reorganizing transgenic DH-DH, and their uses |
| CA3187680A1 (en) | 2020-09-11 | 2022-03-17 | Yashu Liu | Identification and production of antigen-specific antibodies |
| WO2022132943A1 (en) | 2020-12-16 | 2022-06-23 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized fc alpha receptors |
| TW202430558A (zh) * | 2023-01-18 | 2024-08-01 | 美商基利科學股份有限公司 | 人類免疫球蛋白重鏈長cdr3轉殖基因構築體及其用途 |
| WO2026030428A2 (en) | 2024-08-01 | 2026-02-05 | Regeneron Pharmaceuticals, Inc. | Prostate-specific antigen peptides and uses thereof |
| WO2026035843A2 (en) | 2024-08-06 | 2026-02-12 | Regeneron Pharmaceuticals, Inc. | Non-human animals having modified immunoglobulin heavy chain constant region locus and uses thereof |
Family Cites Families (67)
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|---|---|---|---|---|
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| EP1690934A3 (en) | 1990-01-12 | 2008-07-30 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| ATE300615T1 (de) | 1990-08-29 | 2005-08-15 | Genpharm Int | Transgene mäuse fähig zur produktion heterologer antikörper |
| DE69424134T2 (de) | 1993-12-03 | 2000-09-21 | Terumo K.K., Tokio/Tokyo | Stereoskopisches Bildanzeigesystem |
| US5670356A (en) | 1994-12-12 | 1997-09-23 | Promega Corporation | Modified luciferase |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5874304A (en) | 1996-01-18 | 1999-02-23 | University Of Florida Research Foundation, Inc. | Humanized green fluorescent protein genes and methods |
| EP1500329B1 (en) | 1996-12-03 | 2012-03-21 | Amgen Fremont Inc. | Human antibodies that specifically bind human TNF alpha |
| GB9823930D0 (en) | 1998-11-03 | 1998-12-30 | Babraham Inst | Murine expression of human ig\ locus |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| CA2440676A1 (en) | 2001-03-22 | 2002-10-03 | Abbott Gmbh & Co. Kg | Transgenic animals expressing antibodies specific for genes of interest and uses thereof |
| US7744893B2 (en) * | 2002-06-05 | 2010-06-29 | Baylor College Of Medicine | T cell receptor CDR3 sequences associated with multiple sclerosis and compositions comprising same |
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| AU2007235496B2 (en) | 2006-03-31 | 2013-11-21 | E. R. Squibb & Sons, L.L.C. | Transgenic animals expressing chimeric antibodies for use in preparing human antibodies |
| ES2398076T3 (es) | 2006-06-02 | 2013-03-13 | Regeneron Pharmaceuticals, Inc. | Anticuerpos de alta afinidad contra el receptor de IL-6 humano |
| DK2602323T3 (en) | 2007-06-01 | 2018-04-16 | Open Monoclonal Tech Inc | Compositions and Methods for Inhibiting Endogenous Immunoglobin Genes and Producing Transgenic Human Idiotypic Antibodies |
| EP2262898B1 (en) | 2008-03-07 | 2018-01-24 | Regeneron Pharmaceuticals, Inc. | Es cell-derived mice from diploid host embryo injection |
| PL3456190T3 (pl) | 2008-06-27 | 2022-06-06 | Merus N.V. | Wytwarzające przeciwciała transgeniczne zwierzę z gatunku myszy |
| EP2346994B1 (en) | 2008-09-30 | 2022-02-16 | Ablexis, LLC | Knock-in mice for the production of chimeric antibodies |
| BR112012000536A2 (pt) | 2009-07-08 | 2020-08-11 | Kymab Limited | métodos para produção de anticorpo ou cadeia leve ou pesada de anticorpo específico para um antígeno desejado, para produção de anticorpo ou cadeia de anticorpo e seu uso, composição farmacêutica e derivado de anticorpo quimérico |
| US8754287B2 (en) | 2009-12-10 | 2014-06-17 | Regeneron Pharmaceuticals, Inc. | Mice that make heavy chain antibodies |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| US20120021409A1 (en) | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| SI2501817T2 (sl) | 2010-02-08 | 2021-09-30 | Regeneron Pharmaceuticals, Inc. | Miš z navadno lahko verigo |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US20130185821A1 (en) | 2010-02-08 | 2013-07-18 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| KR102203727B1 (ko) | 2010-03-31 | 2021-01-18 | 아블렉시스, 엘엘씨 | 키메라 항체의 제조를 위한 비-인간 동물의 유전적 조작 |
| US9012717B2 (en) | 2010-06-22 | 2015-04-21 | Regeneron Pharmaceuticals, Inc. | Human lambda light chain mice |
| JP6482757B2 (ja) | 2010-07-26 | 2019-03-13 | トリアンニ インコーポレイテッドＴｒｉａｎｎｉ，Ｉｎｃ． | トランスジェニック動物および使用方法 |
| SG10201912639SA (en) | 2010-08-02 | 2020-02-27 | Regeneron Pharma | Mice that make binding proteins comprising vl domains |
| RU2722373C2 (ru) | 2011-02-25 | 2020-05-29 | Редженерон Фармасьютикалс, Инк. | Мыши adam6 |
| BR112014006394A2 (pt) * | 2011-09-19 | 2017-03-28 | Kymab Ltd | manipulação de diversidade genética de imunoglobulina e terapêuticos multi-anticorpos |
| CA2791109C (en) | 2011-09-26 | 2021-02-16 | Merus B.V. | Generation of binding molecules |
| KR20160098514A (ko) | 2011-10-17 | 2016-08-18 | 리제너론 파아마슈티컬스, 인크. | 제한된 면역글로불린 중쇄 마우스 |
| CA2854233C (en) | 2011-11-04 | 2020-05-12 | Zymeworks Inc. | Stable heterodimeric antibody design with mutations in the fc domain |
| RS62023B1 (sr) * | 2012-02-01 | 2021-07-30 | Regeneron Pharma | Humanizovani glodari koji eksprimiraju teške lance koji sadrže vl domene |
| IN2014DN08163A (https=) | 2012-03-06 | 2015-05-01 | Regeneron Pharma | |
| KR102228296B1 (ko) | 2012-03-16 | 2021-03-17 | 리제너론 파마슈티칼스 인코포레이티드 | 히스티딘 공학처리된 경쇄 항체 및 그것을 생성하기 위한 유전자 변형된 비-사람 동물 |
| SG10201700360VA (en) | 2012-03-16 | 2017-03-30 | Regeneron Pharma | Non-human animals expressing ph-sensitive immunoglobulin sequences |
| MX2014011047A (es) | 2012-03-16 | 2015-04-08 | Regeneron Pharma | Ratones que producen proteinas de union a un antigeno con caracteristicas de union dependientes del ph. |
| US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
| RU2014153674A (ru) | 2012-06-05 | 2016-07-27 | Регенерон Фармасьютикалз, Инк. | Способ получения полностью человеческих биспецифических антител с применением общей легкой цепи |
| PT3597037T (pt) * | 2012-06-12 | 2021-06-01 | Regeneron Pharma | Animais não humanos humanizados com lócus de cadeia pesada de imunoglobulina restrito |
| HRP20231356T1 (hr) | 2012-12-14 | 2024-02-16 | Omniab, Inc. | Polinukleotidi koji kodiraju protutijela glodavaca s ljudskim idiotipovima i životinje koje ih sadrže |
| EP2840892B1 (en) * | 2013-02-20 | 2018-04-18 | Regeneron Pharmaceuticals, Inc. | Non-human animals with modified immunoglobulin heavy chain sequences |
| WO2014160202A1 (en) | 2013-03-13 | 2014-10-02 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| CN105189545A (zh) | 2013-03-13 | 2015-12-23 | 瑞泽恩制药公司 | 常见轻链小鼠 |
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| KR102276752B1 (ko) * | 2014-03-21 | 2021-07-13 | 리제너론 파마슈티칼스 인코포레이티드 | 단일 도메인 결합 단백질을 생산하는 비-인간 동물 |
| HUE049405T2 (hu) | 2014-06-23 | 2020-09-28 | Regeneron Pharma | Nukleáz-közvetített DNS-összeállítás |
| ES2731437T3 (es) | 2014-11-21 | 2019-11-15 | Regeneron Pharma | Métodos y composiciones para la modificación genética dirigida mediante el uso de pares de ARN guías |
| US9410301B2 (en) | 2014-12-09 | 2016-08-09 | Theophile Bourgeois | Patch system and method for oil boom |
| KR102530821B1 (ko) | 2014-12-19 | 2023-05-10 | 리제너론 파마슈티칼스 인코포레이티드 | 단일 단계 다중 표적화를 통한 표적화된 유전자 변형을 위한 방법 및 조성물 |
| EP3271403A1 (en) | 2015-03-19 | 2018-01-24 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| HUE061619T2 (hu) | 2016-06-03 | 2023-07-28 | Regeneron Pharma | Exogén terminális dezoxinukleotid-transzferázt expresszáló rágcsálók |
| WO2018128691A1 (en) * | 2016-11-04 | 2018-07-12 | Regeneron Pharmaceuticals, Inc. | Non-human animals having an engineered immunoglobulin lambda light chain locus |
| CN207626880U (zh) | 2017-05-19 | 2018-07-20 | 厦门汇成峰户外用品有限公司 | 一种导演椅 |
| EP3476942B1 (en) * | 2017-10-27 | 2022-01-26 | Trianni, Inc. | Long germline dh genes and long hcdr3 antibodies |
| DK4140297T3 (da) | 2017-12-05 | 2025-06-23 | Regeneron Pharma | Mus med en konstrueret immunglobulin-lambda-letkæde og anvendelser deraf |
| IL318469A (en) * | 2018-06-14 | 2025-03-01 | Regeneron Pharma | Non-human animals capable of reorganizing transgenic DH-DH, and their uses |
-
2019
- 2019-06-13 IL IL318469A patent/IL318469A/en unknown
- 2019-06-14 US US17/252,014 patent/US20210251202A1/en active Pending
- 2019-06-14 ES ES21213824T patent/ES2994581T3/es active Active
- 2019-06-14 PL PL21213824.2T patent/PL4023059T3/pl unknown
- 2019-06-14 PT PT212138242T patent/PT4023059T/pt unknown
- 2019-06-14 EP EP19737613.0A patent/EP3629720B1/en active Active
- 2019-06-14 CN CN202110654221.0A patent/CN113430207A/zh active Pending
- 2019-06-14 KR KR1020227031578A patent/KR102617284B1/ko active Active
- 2019-06-14 HU HUE21213824A patent/HUE069544T2/hu unknown
- 2019-06-14 SI SI201930180T patent/SI3629720T1/sl unknown
- 2019-06-14 PL PL19737613T patent/PL3629720T3/pl unknown
- 2019-06-14 MX MX2020013652A patent/MX391767B/es unknown
- 2019-06-14 IL IL305557A patent/IL305557B2/en unknown
- 2019-06-14 DK DK21213824.2T patent/DK4023059T3/da active
- 2019-06-14 KR KR1020207036226A patent/KR102444180B1/ko active Active
- 2019-06-14 SM SM20240501T patent/SMT202400501T1/it unknown
- 2019-06-14 KR KR1020237034902A patent/KR102933824B1/ko active Active
- 2019-06-14 TW TW108120728A patent/TWI840372B/zh active
- 2019-06-14 JP JP2020569099A patent/JP7182647B2/ja active Active
- 2019-06-14 SM SM20220126T patent/SMT202200126T1/it unknown
- 2019-06-14 EP EP24203669.7A patent/EP4464720A3/en active Pending
- 2019-06-14 US US16/442,063 patent/US20190380316A1/en active Pending
- 2019-06-14 RS RS20241384A patent/RS66298B1/sr unknown
- 2019-06-14 CN CN201980039940.2A patent/CN112312766A/zh active Pending
- 2019-06-14 LT LTEPPCT/US2019/037285T patent/LT3629720T/lt unknown
- 2019-06-14 LT LTEP21213824.2T patent/LT4023059T/lt unknown
- 2019-06-14 SG SG11202012084WA patent/SG11202012084WA/en unknown
- 2019-06-14 HR HRP20220509TT patent/HRP20220509T8/hr unknown
- 2019-06-14 WO PCT/US2019/037285 patent/WO2019241692A1/en not_active Ceased
- 2019-06-14 TW TW113118339A patent/TW202500752A/zh unknown
- 2019-06-14 AU AU2019287727A patent/AU2019287727B2/en active Active
- 2019-06-14 FI FIEP21213824.2T patent/FI4023059T3/fi active
- 2019-06-14 DK DK19737613.0T patent/DK3629720T3/da active
- 2019-06-14 ES ES19737613T patent/ES2907067T3/es active Active
- 2019-06-14 EP EP21213824.2A patent/EP4023059B1/en active Active
- 2019-06-14 HR HRP20241705TT patent/HRP20241705T1/hr unknown
- 2019-06-14 RS RS20220366A patent/RS63117B1/sr unknown
- 2019-06-14 PT PT197376130T patent/PT3629720T/pt unknown
- 2019-06-14 SI SI201930863T patent/SI4023059T1/sl unknown
- 2019-06-14 CA CA3103646A patent/CA3103646C/en active Active
- 2019-06-14 IL IL279311A patent/IL279311B2/en unknown
-
2020
- 2020-12-04 ZA ZA2020/07560A patent/ZA202007560B/en unknown
- 2020-12-14 MX MX2022004537A patent/MX2022004537A/es unknown
-
2022
- 2022-03-30 JP JP2022056227A patent/JP2022079617A/ja not_active Withdrawn
- 2022-04-18 CY CY20221100288T patent/CY1125121T1/el unknown
- 2022-11-10 AU AU2022268350A patent/AU2022268350B2/en active Active
-
2023
- 2023-12-21 JP JP2023215643A patent/JP2024019660A/ja not_active Withdrawn
-
2024
- 2024-06-21 JP JP2024100324A patent/JP7815335B2/ja active Active
-
2025
- 2025-01-07 AU AU2025200075A patent/AU2025200075A1/en active Pending
- 2025-11-07 JP JP2025188198A patent/JP2026016787A/ja active Pending
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