CN112312766A - 在免疫球蛋白重链编码序列中具有dh-dh重排能力的非人动物 - Google Patents

在免疫球蛋白重链编码序列中具有dh-dh重排能力的非人动物 Download PDF

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CN112312766A
CN112312766A CN201980039940.2A CN201980039940A CN112312766A CN 112312766 A CN112312766 A CN 112312766A CN 201980039940 A CN201980039940 A CN 201980039940A CN 112312766 A CN112312766 A CN 112312766A
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human
gene
gene segment
rodent
unrearranged
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A·J·莫菲
L·麦克唐纳
C·郭
J·麦克沃特
V·沃罗尼纳
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
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    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2217/20—Animal model comprising regulated expression system
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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CN201980039940.2A 2018-06-14 2019-06-14 在免疫球蛋白重链编码序列中具有dh-dh重排能力的非人动物 Pending CN112312766A (zh)

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Application Number Priority Date Filing Date Title
CN202110654221.0A CN113430207A (zh) 2018-06-14 2019-06-14 在免疫球蛋白重链编码序列中具有dh-dh重排能力的非人动物

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862685203P 2018-06-14 2018-06-14
US62/685,203 2018-06-14
US201862702206P 2018-07-23 2018-07-23
US62/702,206 2018-07-23
US201962812580P 2019-03-01 2019-03-01
US62/812,580 2019-03-01
PCT/US2019/037285 WO2019241692A1 (en) 2018-06-14 2019-06-14 Non-human animals capable of dh-dh rearrangement in the immunoglobulin heavy chain coding sequences

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CN202110654221.0A Division CN113430207A (zh) 2018-06-14 2019-06-14 在免疫球蛋白重链编码序列中具有dh-dh重排能力的非人动物

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CN202110654221.0A Pending CN113430207A (zh) 2018-06-14 2019-06-14 在免疫球蛋白重链编码序列中具有dh-dh重排能力的非人动物

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EP (3) EP3629720B1 (https=)
JP (6) JP7182647B2 (https=)
KR (4) KR102933824B1 (https=)
CN (2) CN112312766A (https=)
AU (3) AU2019287727B2 (https=)
CA (1) CA3103646C (https=)
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DK (2) DK3629720T3 (https=)
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