JP2025518638A5 - - Google Patents

Info

Publication number
JP2025518638A5
JP2025518638A5 JP2025513495A JP2025513495A JP2025518638A5 JP 2025518638 A5 JP2025518638 A5 JP 2025518638A5 JP 2025513495 A JP2025513495 A JP 2025513495A JP 2025513495 A JP2025513495 A JP 2025513495A JP 2025518638 A5 JP2025518638 A5 JP 2025518638A5
Authority
JP
Japan
Prior art keywords
transposase
protein
vitro method
nucleic acid
aptamer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2025513495A
Other languages
English (en)
Japanese (ja)
Other versions
JP2025518638A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2023/062736 external-priority patent/WO2023218021A1/en
Publication of JP2025518638A publication Critical patent/JP2025518638A/ja
Publication of JP2025518638A5 publication Critical patent/JP2025518638A5/ja
Pending legal-status Critical Current

Links

JP2025513495A 2022-05-13 2023-05-12 導入遺伝子の発現および核局在化を改善するためのトランスポザーゼの使用 Pending JP2025518638A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202263341619P 2022-05-13 2022-05-13
US63/341,619 2022-05-13
EP22191966 2022-08-24
EP22191966.5 2022-08-24
PCT/EP2023/062736 WO2023218021A1 (en) 2022-05-13 2023-05-12 Use of transposases for improving transgene expression and nuclear localization

Publications (2)

Publication Number Publication Date
JP2025518638A JP2025518638A (ja) 2025-06-18
JP2025518638A5 true JP2025518638A5 (https=) 2026-04-08

Family

ID=86605260

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2025513495A Pending JP2025518638A (ja) 2022-05-13 2023-05-12 導入遺伝子の発現および核局在化を改善するためのトランスポザーゼの使用

Country Status (7)

Country Link
EP (1) EP4522735A1 (https=)
JP (1) JP2025518638A (https=)
KR (1) KR20250010025A (https=)
CN (1) CN119487184A (https=)
AU (1) AU2023269540A1 (https=)
CA (1) CA3253152A1 (https=)
WO (1) WO2023218021A1 (https=)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110047635A1 (en) * 2006-08-28 2011-02-24 University of Hawail Methods and compositions for transposon-mediated transgenesis
CA3082450A1 (en) * 2017-11-21 2019-05-31 Crispr Therapeutics Ag Materials and methods for treatment of autosomal dominant retinitis pigmentosa
US12338453B2 (en) * 2018-12-17 2025-06-24 Consejo Superior De Investigaciones Científicas (Csic) Method for the introduction of genetic information in cell by site-specific integration system
WO2020243085A1 (en) 2019-05-24 2020-12-03 The Trustees Of Columbia University In The City Of New York Engineered cas-transposon system for programmable and site-directed dna transpositions
CN115968301A (zh) * 2020-04-20 2023-04-14 综合Dna技术公司 优化的蛋白融合和接头
MX2022015284A (es) * 2020-06-05 2023-01-19 Univ California Composiciones y metodos para la edicion del epigenoma.
CA3173696A1 (en) * 2020-07-17 2022-01-20 Volker Sandig Hyperactive transposons and transposases
AU2021403660A1 (en) 2020-12-16 2023-07-06 Universitat Pompeu Fabra Programmable transposases and uses thereof

Similar Documents

Publication Publication Date Title
JP6946384B2 (ja) 脂質ナノ粒子を含む医薬組成物
JP6921797B2 (ja) ヒト疾患に関連する生物製剤およびタンパク質の産生のための修飾ポリヌクレオチド
CN109803977B (zh) 核酸产品及其施用方法
EP3443086B1 (en) Cas9 fusion molecules, gene editing systems, and methods of use thereof
JP5902679B2 (ja) IL−4Rαに結合する涙液リポカリンムテイン
TW202136509A (zh) 用於基因編輯之經修飾引導rna
US20200340012A1 (en) Crispr-cas genome engineering via a modular aav delivery system
JP2022507454A5 (https=)
JP2022540318A5 (https=)
JP2022519507A5 (https=)
JP2023534693A5 (https=)
JP2023554504A5 (https=)
JP2022545950A5 (https=)
EP4396340A1 (en) Rna-guided genome recombineering at kilobase scale
JP2026500040A (ja) 複合体及びその使用
EP4543908A1 (en) Compositions and methods for epigenetic editing
CN117721096A (zh) 重组人透明质酸酶变体及其应用
JP2025518638A5 (https=)
JP2023507034A5 (https=)
JP2024515113A (ja) 重篤な疾患を処置するためのb細胞ベースのタンパク質工場の操作
JPWO2023120658A5 (https=)
JP2024507451A5 (https=)
JP2023553701A5 (https=)
Vavilis et al. mRNA in the context of protein replacement therapy. Pharmaceutics 2023; 15: 166
CN117561331A (zh) 用于产生经基因修饰的原代细胞的方法和组合物