JP2025516005A - 疼痛の処置のためのｎａｖ１．８の二環式複素環アミド阻害剤 - Google Patents
疼痛の処置のためのｎａｖ１．８の二環式複素環アミド阻害剤 Download PDFInfo
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- JP2025516005A JP2025516005A JP2024563159A JP2024563159A JP2025516005A JP 2025516005 A JP2025516005 A JP 2025516005A JP 2024563159 A JP2024563159 A JP 2024563159A JP 2024563159 A JP2024563159 A JP 2024563159A JP 2025516005 A JP2025516005 A JP 2025516005A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN202211024240 | 2022-04-25 | ||
| IN202211024240 | 2022-04-25 | ||
| IN202311013223 | 2023-02-27 | ||
| IN202311013223 | 2023-02-27 | ||
| PCT/US2023/019879 WO2023211990A1 (en) | 2022-04-25 | 2023-04-25 | Bicyclic heterocyclic amide inhibitors of na v1.8 for the treatment of pain |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2025516005A true JP2025516005A (ja) | 2025-05-23 |
| JPWO2023211990A5 JPWO2023211990A5 (https=) | 2026-03-17 |
| JP2025516005A5 JP2025516005A5 (https=) | 2026-03-17 |
Family
ID=86469337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024563159A Pending JP2025516005A (ja) | 2022-04-25 | 2023-04-25 | 疼痛の処置のためのｎａｖ１．８の二環式複素環アミド阻害剤 |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP4514789A1 (https=) |
| JP (1) | JP2025516005A (https=) |
| KR (1) | KR20250006217A (https=) |
| CN (1) | CN119585247A (https=) |
| AU (1) | AU2023263309A1 (https=) |
| CA (1) | CA3256486A1 (https=) |
| CL (1) | CL2024003258A1 (https=) |
| CO (1) | CO2024015763A2 (https=) |
| CR (1) | CR20240512A (https=) |
| DO (1) | DOP2024000215A (https=) |
| GE (1) | GEAP202516637A (https=) |
| IL (1) | IL316433A (https=) |
| JO (1) | JOP20240238A1 (https=) |
| MX (1) | MX2024013065A (https=) |
| PE (1) | PE20251183A1 (https=) |
| WO (1) | WO2023211990A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2025529613A (ja) | 2022-08-12 | 2025-09-09 | グアンジョウ フェルミオン テクノロジー カンパニー リミテッド | 電位開口型ナトリウムチャネル阻害剤としての化合物 |
| WO2025122953A1 (en) | 2023-12-07 | 2025-06-12 | Vertex Pharmaceuticals Incorporated | Dosing regimens and formulations of suzetrigine for use in the treatment of acute and chronic pain |
| TW202547515A (zh) * | 2024-04-30 | 2025-12-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 芳香環類化合物、其製備方法及其在醫藥上的應用 |
| WO2026001999A1 (zh) * | 2024-06-25 | 2026-01-02 | 江苏恒瑞医药股份有限公司 | 芳香环类化合物、其制备方法及其在医药上的应用 |
| WO2026030525A1 (en) | 2024-07-31 | 2026-02-05 | Vertex Pharmaceuticals Incorporated | Zilvetrigine dosage forms and dosing regimens for treating pain |
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| HU196714B (en) | 1984-10-04 | 1989-01-30 | Monsanto Co | Process for producing non-aqueous composition comprising somatotropin |
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| KR102295748B1 (ko) | 2013-01-31 | 2021-09-01 | 버텍스 파마슈티칼스 인코포레이티드 | 나트륨 채널의 조절제로서의 피리돈 아미드 |
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| US12441703B2 (en) | 2019-01-10 | 2025-10-14 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
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| WO2020261114A1 (en) | 2019-06-27 | 2020-12-30 | Glaxosmithkline Intellectual Property Development Limited | 2,3-dihydroquinazolin compounds as nav1.8 inhibitors |
| WO2021032074A1 (zh) | 2019-08-19 | 2021-02-25 | 江苏恒瑞医药股份有限公司 | 苯甲酰胺稠芳环类衍生物、其制备方法及其在医药上的应用 |
| CA3164134A1 (en) | 2019-12-06 | 2021-06-10 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofurans as modulators of sodium channels |
| JP2023530319A (ja) | 2020-06-17 | 2023-07-14 | メルク・シャープ・アンド・ドーム・エルエルシー | Ｎａｖ１．８阻害剤としての２－オキソ－オキサゾリジン－５－カルボキサミド |
| BR112022024476A2 (pt) | 2020-06-17 | 2022-12-27 | Merck Sharp & Dohme Llc | 5-oxopirrolidino-3-carboxamidas como inibidores de nav1.8 |
| GEP20257750B (en) | 2020-06-17 | 2025-03-25 | Merck Sharp & Dohme Llc | 2-oxoimidazolidine-4-carboxamides as nav1.8 inhibitors |
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-
2023
- 2023-04-25 IL IL316433A patent/IL316433A/en unknown
- 2023-04-25 GE GEAP202516637A patent/GEAP202516637A/en unknown
- 2023-04-25 WO PCT/US2023/019879 patent/WO2023211990A1/en not_active Ceased
- 2023-04-25 CR CR20240512A patent/CR20240512A/es unknown
- 2023-04-25 JP JP2024563159A patent/JP2025516005A/ja active Pending
- 2023-04-25 EP EP23725500.5A patent/EP4514789A1/en active Pending
- 2023-04-25 PE PE2024002316A patent/PE20251183A1/es unknown
- 2023-04-25 CN CN202380049371.6A patent/CN119585247A/zh active Pending
- 2023-04-25 CA CA3256486A patent/CA3256486A1/en active Pending
- 2023-04-25 KR KR1020247039008A patent/KR20250006217A/ko active Pending
- 2023-04-25 AU AU2023263309A patent/AU2023263309A1/en active Pending
-
2024
- 2024-10-22 JO JOJO/P/2024/0238A patent/JOP20240238A1/ar unknown
- 2024-10-23 MX MX2024013065A patent/MX2024013065A/es unknown
- 2024-10-24 DO DO2024000215A patent/DOP2024000215A/es unknown
- 2024-10-25 CL CL2024003258A patent/CL2024003258A1/es unknown
- 2024-11-20 CO CONC2024/0015763A patent/CO2024015763A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CR20240512A (es) | 2025-03-03 |
| CO2024015763A2 (es) | 2025-02-13 |
| EP4514789A1 (en) | 2025-03-05 |
| IL316433A (en) | 2024-12-01 |
| JOP20240238A1 (ar) | 2024-10-22 |
| AU2023263309A1 (en) | 2024-12-05 |
| CA3256486A1 (en) | 2023-11-02 |
| GEAP202516637A (en) | 2025-03-25 |
| WO2023211990A1 (en) | 2023-11-02 |
| DOP2024000215A (es) | 2025-04-30 |
| CL2024003258A1 (es) | 2025-02-14 |
| MX2024013065A (es) | 2024-12-06 |
| KR20250006217A (ko) | 2025-01-10 |
| CN119585247A (zh) | 2025-03-07 |
| PE20251183A1 (es) | 2025-04-23 |
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