KR20250006217A - 통증 치료를 위한 Naν1.8의 바이사이클릭 헤테로사이클릭 아미드 억제제 - Google Patents
통증 치료를 위한 Naν1.8의 바이사이클릭 헤테로사이클릭 아미드 억제제 Download PDFInfo
- Publication number
- KR20250006217A KR20250006217A KR1020247039008A KR20247039008A KR20250006217A KR 20250006217 A KR20250006217 A KR 20250006217A KR 1020247039008 A KR1020247039008 A KR 1020247039008A KR 20247039008 A KR20247039008 A KR 20247039008A KR 20250006217 A KR20250006217 A KR 20250006217A
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- pharmaceutically acceptable
- isomer
- acceptable salt
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN202211024240 | 2022-04-25 | ||
| IN202211024240 | 2022-04-25 | ||
| IN202311013223 | 2023-02-27 | ||
| IN202311013223 | 2023-02-27 | ||
| PCT/US2023/019879 WO2023211990A1 (en) | 2022-04-25 | 2023-04-25 | Bicyclic heterocyclic amide inhibitors of na v1.8 for the treatment of pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20250006217A true KR20250006217A (ko) | 2025-01-10 |
Family
ID=86469337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020247039008A Pending KR20250006217A (ko) | 2022-04-25 | 2023-04-25 | 통증 치료를 위한 Naν1.8의 바이사이클릭 헤테로사이클릭 아미드 억제제 |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP4514789A1 (https=) |
| JP (1) | JP2025516005A (https=) |
| KR (1) | KR20250006217A (https=) |
| CN (1) | CN119585247A (https=) |
| AU (1) | AU2023263309A1 (https=) |
| CA (1) | CA3256486A1 (https=) |
| CL (1) | CL2024003258A1 (https=) |
| CO (1) | CO2024015763A2 (https=) |
| CR (1) | CR20240512A (https=) |
| DO (1) | DOP2024000215A (https=) |
| GE (1) | GEAP202516637A (https=) |
| IL (1) | IL316433A (https=) |
| JO (1) | JOP20240238A1 (https=) |
| MX (1) | MX2024013065A (https=) |
| PE (1) | PE20251183A1 (https=) |
| WO (1) | WO2023211990A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2025529613A (ja) | 2022-08-12 | 2025-09-09 | グアンジョウ フェルミオン テクノロジー カンパニー リミテッド | 電位開口型ナトリウムチャネル阻害剤としての化合物 |
| WO2025122953A1 (en) | 2023-12-07 | 2025-06-12 | Vertex Pharmaceuticals Incorporated | Dosing regimens and formulations of suzetrigine for use in the treatment of acute and chronic pain |
| TW202547515A (zh) * | 2024-04-30 | 2025-12-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 芳香環類化合物、其製備方法及其在醫藥上的應用 |
| WO2026001999A1 (zh) * | 2024-06-25 | 2026-01-02 | 江苏恒瑞医药股份有限公司 | 芳香环类化合物、其制备方法及其在医药上的应用 |
| WO2026030525A1 (en) | 2024-07-31 | 2026-02-05 | Vertex Pharmaceuticals Incorporated | Zilvetrigine dosage forms and dosing regimens for treating pain |
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-
2023
- 2023-04-25 IL IL316433A patent/IL316433A/en unknown
- 2023-04-25 GE GEAP202516637A patent/GEAP202516637A/en unknown
- 2023-04-25 WO PCT/US2023/019879 patent/WO2023211990A1/en not_active Ceased
- 2023-04-25 CR CR20240512A patent/CR20240512A/es unknown
- 2023-04-25 JP JP2024563159A patent/JP2025516005A/ja active Pending
- 2023-04-25 EP EP23725500.5A patent/EP4514789A1/en active Pending
- 2023-04-25 PE PE2024002316A patent/PE20251183A1/es unknown
- 2023-04-25 CN CN202380049371.6A patent/CN119585247A/zh active Pending
- 2023-04-25 CA CA3256486A patent/CA3256486A1/en active Pending
- 2023-04-25 KR KR1020247039008A patent/KR20250006217A/ko active Pending
- 2023-04-25 AU AU2023263309A patent/AU2023263309A1/en active Pending
-
2024
- 2024-10-22 JO JOJO/P/2024/0238A patent/JOP20240238A1/ar unknown
- 2024-10-23 MX MX2024013065A patent/MX2024013065A/es unknown
- 2024-10-24 DO DO2024000215A patent/DOP2024000215A/es unknown
- 2024-10-25 CL CL2024003258A patent/CL2024003258A1/es unknown
- 2024-11-20 CO CONC2024/0015763A patent/CO2024015763A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CR20240512A (es) | 2025-03-03 |
| CO2024015763A2 (es) | 2025-02-13 |
| EP4514789A1 (en) | 2025-03-05 |
| IL316433A (en) | 2024-12-01 |
| JOP20240238A1 (ar) | 2024-10-22 |
| AU2023263309A1 (en) | 2024-12-05 |
| CA3256486A1 (en) | 2023-11-02 |
| GEAP202516637A (en) | 2025-03-25 |
| WO2023211990A1 (en) | 2023-11-02 |
| DOP2024000215A (es) | 2025-04-30 |
| CL2024003258A1 (es) | 2025-02-14 |
| MX2024013065A (es) | 2024-12-06 |
| JP2025516005A (ja) | 2025-05-23 |
| CN119585247A (zh) | 2025-03-07 |
| PE20251183A1 (es) | 2025-04-23 |
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