JP2025510656A5 - - Google Patents

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Publication number
JP2025510656A5
JP2025510656A5 JP2024555128A JP2024555128A JP2025510656A5 JP 2025510656 A5 JP2025510656 A5 JP 2025510656A5 JP 2024555128 A JP2024555128 A JP 2024555128A JP 2024555128 A JP2024555128 A JP 2024555128A JP 2025510656 A5 JP2025510656 A5 JP 2025510656A5
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JP
Japan
Application number
JP2024555128A
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Japanese (ja)
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JPWO2023179703A5 (https=
JP2025510656A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/CN2023/083294 external-priority patent/WO2023179703A1/en
Publication of JP2025510656A publication Critical patent/JP2025510656A/ja
Publication of JPWO2023179703A5 publication Critical patent/JPWO2023179703A5/ja
Publication of JP2025510656A5 publication Critical patent/JP2025510656A5/ja
Pending legal-status Critical Current

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JP2024555128A 2022-03-24 2023-03-23 複素環式化合物、その組成物、及びそれらを用いた治療方法 Pending JP2025510656A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2022082722 2022-03-24
CNPCT/CN2022/082722 2022-03-24
PCT/CN2023/083294 WO2023179703A1 (en) 2022-03-24 2023-03-23 Heterocyclic compounds, compositions thereof, and methods of treatment therewith

Publications (3)

Publication Number Publication Date
JP2025510656A JP2025510656A (ja) 2025-04-15
JPWO2023179703A5 JPWO2023179703A5 (https=) 2026-04-08
JP2025510656A5 true JP2025510656A5 (https=) 2026-04-08

Family

ID=88100085

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024555128A Pending JP2025510656A (ja) 2022-03-24 2023-03-23 複素環式化合物、その組成物、及びそれらを用いた治療方法

Country Status (5)

Country Link
US (1) US20250101028A1 (https=)
EP (1) EP4499639A1 (https=)
JP (1) JP2025510656A (https=)
CN (1) CN118900838A (https=)
WO (1) WO2023179703A1 (https=)

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EP4373822A2 (en) 2021-07-23 2024-05-29 Theras Inc. Compositions and methods for inhibition of ras
JP2024543879A (ja) * 2021-11-24 2024-11-26 メルク・シャープ・アンド・ドーム・エルエルシー Kras変異型タンパク質の小分子阻害剤
JP2025525938A (ja) * 2022-08-05 2025-08-07 セラス, インコーポレイテッド Krasの阻害のための組成物及び方法
WO2024112654A1 (en) 2022-11-21 2024-05-30 Treeline Biosciences, Inc. Spirocyclic dihydropyranopyrimidine kras inhibitors
EP4687905A1 (en) 2023-03-30 2026-02-11 Revolution Medicines, Inc. Compositions for inducing ras gtp hydrolysis and uses thereof
AU2024265078A1 (en) 2023-05-04 2025-12-11 Revolution Medicines, Inc. Combination therapy for a ras related disease or disorder
IL326136A (en) 2023-08-07 2026-03-01 Revolution Medicines Inc RMC-6291 for use in the treatment of a disease or disorder associated with the RAS protein
AU2024323424A1 (en) 2023-08-17 2026-03-05 Treeline Biosciences, Inc. Spirocyclic dihydropyranopyrimidine kras inhibitors
AU2024337913A1 (en) 2023-09-08 2026-03-26 Gilead Sciences, Inc. Pyrimidine-containing polycyclic derivatives as kras g12d modulating compounds
TW202528315A (zh) 2023-09-21 2025-07-16 美商樹線生物科學公司 螺環二氫哌喃并吡啶KRas抑制劑
US20250114339A1 (en) 2023-10-09 2025-04-10 Incyte Corporation Combination therapy comprising a kras g12d inhibitor and an egfr inhibitor
AU2024357850A1 (en) 2023-10-09 2026-04-23 Incyte Corporation Combination therapy using a kras g12d inhibitor and pd-1 inhibitor or pd-l1 inhibitor
US20250154171A1 (en) 2023-10-12 2025-05-15 Revolution Medicines, Inc. Ras inhibitors
WO2025090811A1 (en) * 2023-10-25 2025-05-01 Kumquat Biosciences Inc. Methods of modulating cell proliferation
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors
WO2025245127A1 (en) 2024-05-21 2025-11-27 Treeline Biosciences, Inc. Spirocyclic dihydropyranopyrimidine kras inhibitors
US20250375445A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026035945A1 (en) 2024-08-07 2026-02-12 Tesseract Medicines Us, Llc Covalent-induced drug conjugates targeting kras and comprising a topoisomerase payload
WO2026035947A1 (en) 2024-08-07 2026-02-12 Tesseract Medicines Us, Llc Kras-targeting covalent-induced drug conjugates comprising a topoisomerase payload
WO2026050446A1 (en) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Ras inhibitors
WO2026064520A1 (en) 2024-09-19 2026-03-26 Tesseract Medicines Us, Llc Covalent-induced drug conjugates targeting kras and comprising a tubulin inhibitor payload
WO2026064527A1 (en) 2024-09-19 2026-03-26 Tesseract Medicines Us, Llc Kras-targeting covalent-induced drug conjugates comprising a tubulin inhibitor payload
WO2026072904A2 (en) 2024-09-26 2026-04-02 Revolution Medicines, Inc. Compositions and methods for treating lung cancer

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EP4192585A4 (en) * 2020-08-04 2024-08-21 Mirati Therapeutics, Inc. Kras g12d inhibitors
WO2022132200A1 (en) * 2020-12-15 2022-06-23 Mirati Therapeutics, Inc. Azaquinazoline pan-kras inhibitors
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WO2022247760A1 (zh) * 2021-05-22 2022-12-01 上海科州药物研发有限公司 作为kras抑制剂的杂环化合物,及其制备和治疗用途
WO2022248885A2 (en) * 2021-05-28 2022-12-01 Redx Pharma Plc. Compounds
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CN117858878A (zh) * 2021-08-18 2024-04-09 北京加科思新药研发有限公司 N-环丙基吡啶并[4,3-d]嘧啶-4-胺衍生物及其用途
WO2023056951A1 (zh) * 2021-10-08 2023-04-13 杭州德睿智药科技有限公司 芳基取代并杂环化合物
WO2023061294A1 (zh) * 2021-10-13 2023-04-20 再鼎医药(上海)有限公司 含氮杂环类衍生物调节剂、其制备方法及应用
WO2023072188A1 (zh) * 2021-10-29 2023-05-04 贝达药业股份有限公司 Kras g12d抑制剂及其在医药上的应用
TW202334138A (zh) * 2021-11-05 2023-09-01 美商新領域醫藥公司 癌症治療方法

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