JP2005525332A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005525332A5 JP2005525332A5 JP2003566005A JP2003566005A JP2005525332A5 JP 2005525332 A5 JP2005525332 A5 JP 2005525332A5 JP 2003566005 A JP2003566005 A JP 2003566005A JP 2003566005 A JP2003566005 A JP 2003566005A JP 2005525332 A5 JP2005525332 A5 JP 2005525332A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- nitrogen
- independently
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 208000010877 cognitive disease Diseases 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- -1 phenyloxy, benzyloxy Chemical group 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 2
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- 230000032683 aging Effects 0.000 claims 2
- 230000036506 anxiety Effects 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 125000001589 carboacyl group Chemical group 0.000 claims 2
- 230000006999 cognitive decline Effects 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 208000027061 mild cognitive impairment Diseases 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 239000011593 sulfur Substances 0.000 claims 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 claims 1
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 1
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- ODSVXRSHXWHNNL-UHFFFAOYSA-N 7-(benzenesulfonyl)-5-bromo-4-piperidin-1-ylpyrrolo[2,3-d]pyrimidine Chemical compound C=12C(Br)=CN(S(=O)(=O)C=3C=CC=CC=3)C2=NC=NC=1N1CCCCC1 ODSVXRSHXWHNNL-UHFFFAOYSA-N 0.000 claims 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 208000020401 Depressive disease Diseases 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0202679.7A GB0202679D0 (en) | 2002-02-05 | 2002-02-05 | Novel compounds |
| PCT/EP2003/001117 WO2003066632A1 (en) | 2002-02-05 | 2003-02-04 | Sulphonyl compounds with 5 -ht6 receptor affinity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005525332A JP2005525332A (ja) | 2005-08-25 |
| JP2005525332A5 true JP2005525332A5 (https=) | 2006-01-05 |
Family
ID=9930462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003566005A Pending JP2005525332A (ja) | 2002-02-05 | 2003-02-04 | ５−ｈｔ６受容体アフィニティーを有するスルホニル化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20050090496A1 (https=) |
| EP (1) | EP1472253A1 (https=) |
| JP (1) | JP2005525332A (https=) |
| AU (1) | AU2003244480A1 (https=) |
| GB (1) | GB0202679D0 (https=) |
| WO (1) | WO2003066632A1 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0308696B8 (pt) * | 2002-03-27 | 2021-05-25 | Axovant Sciences Gmbh | composto derivado de quinolina, seu processo de preparação, sua composição farmacêutica e seus usos |
| PT1558582E (pt) | 2003-07-22 | 2006-05-31 | Arena Pharm Inc | Derivados de diaril- e aril-heteroaril-ureia como moduladores do receptor de serotonina 5-ht2a uteis para a profilaxia e tratamento de desordens relacionadas com o mesmo |
| SE0302760D0 (sv) * | 2003-10-20 | 2003-10-20 | Biovitrum Ab | New compounds |
| TW200522944A (en) * | 2003-12-23 | 2005-07-16 | Lilly Co Eli | CB1 modulator compounds |
| KR100783255B1 (ko) | 2004-02-13 | 2007-12-06 | 워너-램버트 캄파니 엘엘씨 | 안드로젠 수용체 조절제 |
| JP2007532621A (ja) | 2004-04-13 | 2007-11-15 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | アンドロゲンモジュレータ |
| WO2005102990A1 (en) | 2004-04-22 | 2005-11-03 | Warner-Lambert Company Llc | Androgen modulators |
| TW200724139A (en) | 2005-05-05 | 2007-07-01 | Warner Lambert Co | Androgen modulators |
| WO2006127587A1 (en) | 2005-05-20 | 2006-11-30 | Vertex Pharmaceuticals Incorporated | Pyrrolopyridines useful as inhibitors of protein kinase |
| CA2637531A1 (en) * | 2006-02-17 | 2007-08-30 | Memory Pharmaceuticals Corporation | Compounds having 5-ht6 receptor affinity |
| US20080200471A1 (en) * | 2007-02-16 | 2008-08-21 | Memory Pharmaceuticals Corporation | 6' substituted compounds having 5-ht6 receptor affinity |
| JP2010521516A (ja) * | 2007-03-21 | 2010-06-24 | グラクソ グループ リミテッド | 疼痛および過敏性腸症候群の治療におけるキノリン誘導体の使用 |
| CN101730680A (zh) * | 2007-05-24 | 2010-06-09 | 记忆医药公司 | 具有5-ht6受体亲和力的4’取代的化合物 |
| AU2008286760A1 (en) * | 2007-08-15 | 2009-02-19 | Memory Pharmaceuticals Corporation | 3' substituted compounds having 5-HT6 receptor affinity |
| EP2508177A1 (en) | 2007-12-12 | 2012-10-10 | Glaxo Group Limited | Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline |
| WO2009123714A2 (en) | 2008-04-02 | 2009-10-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
| US20100016297A1 (en) * | 2008-06-24 | 2010-01-21 | Memory Pharmaceuticals Corporation | Alkyl-substituted 3' compounds having 5-ht6 receptor affinity |
| US20100022581A1 (en) * | 2008-07-02 | 2010-01-28 | Memory Pharmaceuticals Corporation | Pyrrolidine-substituted azaindole compounds having 5-ht6 receptor affinity |
| US20100029629A1 (en) * | 2008-07-25 | 2010-02-04 | Memory Pharmaceuticals Corporation | Acyclic compounds having 5-ht6 receptor affinity |
| US20100056531A1 (en) * | 2008-08-22 | 2010-03-04 | Memory Pharmaceuticals Corporation | Alkyl-substituted 3' compounds having 5-ht6 receptor affinity |
| WO2010062321A1 (en) | 2008-10-28 | 2010-06-03 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto |
| WO2015090233A1 (en) | 2013-12-20 | 2015-06-25 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic compounds and their application in pharmaceuticals |
| EP3166924B1 (en) | 2014-07-08 | 2019-02-20 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic derivatives and pharmaceutical applications thereof |
| WO2016201373A1 (en) | 2015-06-12 | 2016-12-15 | Axovant Sciences Ltd. | Diaryl and arylheteroaryl urea derivatives useful for the prophylaxis and treatment of rem sleep behavior disorder |
| WO2017011767A2 (en) | 2015-07-15 | 2017-01-19 | Axovant Sciences Ltd. | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of hallucinations associated with a neurodegenerative disease |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2051837A (en) * | 1934-07-05 | 1936-08-25 | Siemens App Und Maschinen Gmbh | Automatic control arrangement for aircraft |
| US2051832A (en) * | 1934-12-13 | 1936-08-25 | Thomas H Edelblute | Puller hoist |
| US6194410B1 (en) * | 1998-03-11 | 2001-02-27 | Hoffman-La Roche Inc. | Pyrazolopyrimidine and pyrazolines and process for preparation thereof |
| PA8474101A1 (es) * | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
| BR9911365A (pt) * | 1998-06-19 | 2001-03-13 | Pfizer Prod Inc | Compostos pirrolo[2,3-d]pirimidina |
| US6090761A (en) * | 1998-12-22 | 2000-07-18 | Exxon Research And Engineering Company | Non-sludging, high temperature resistant food compatible lubricant for food processing machinery |
| WO2001012629A1 (en) * | 1999-08-12 | 2001-02-22 | Nps Allelix Corp. | Azaindoles having serotonin receptor affinity |
| SE0002754D0 (sv) * | 2000-07-21 | 2000-07-21 | Pharmacia & Upjohn Ab | New pharmaceutical combination formulation and method of treatment with the combination |
| GB0115109D0 (en) * | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
| GB0115393D0 (en) * | 2001-06-23 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
-
2002
- 2002-02-05 GB GBGB0202679.7A patent/GB0202679D0/en not_active Ceased
-
2003
- 2003-02-04 US US10/503,682 patent/US20050090496A1/en not_active Abandoned
- 2003-02-04 WO PCT/EP2003/001117 patent/WO2003066632A1/en not_active Ceased
- 2003-02-04 AU AU2003244480A patent/AU2003244480A1/en not_active Abandoned
- 2003-02-04 EP EP03737311A patent/EP1472253A1/en not_active Withdrawn
- 2003-02-04 JP JP2003566005A patent/JP2005525332A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005525332A5 (https=) | ||
| TW202341983A (zh) | 用於降解突變kras蛋白之化合物及其應用 | |
| ES2750655T3 (es) | Derivados de pirrolo[2,3-d]pirimidina útiles para inhibir la Janus cinasa | |
| RU2347778C2 (ru) | Новые антагонисты р2х7 рецепторов, способ их получения, фармацевтическая композиция, способ лечения и применение на их основе | |
| JP6527534B2 (ja) | ヒストンメチルトランスフェラーゼ及びｄｎａメチルトランスフェラーゼの二重阻害剤としての新規化合物 | |
| RU2004132203A (ru) | Индолилмалеимидные производные | |
| JP2005508962A5 (https=) | ||
| RU2003115429A (ru) | Производные имида индолилмалеиновой кислоты как ингибиторы протеинкиназы с | |
| JP2005519932A5 (https=) | ||
| RU2004131641A (ru) | Новые соединения | |
| JP2005519908A5 (https=) | ||
| CA2491632A1 (en) | Pyrimidinylaminobenzamide derivatives and their use as inhibitors of tyrosine kinases | |
| JP2005511531A5 (https=) | ||
| JP2007538092A5 (https=) | ||
| JP2004532240A5 (https=) | ||
| JP2014528433A5 (https=) | ||
| JP2006523194A5 (https=) | ||
| RU2004106783A (ru) | Производные 4-амино-6-фенилпирроло[2, 3] пиримидина | |
| RU2007116119A (ru) | Производные циклоспорина, замещенные 3-эфиром и 3-тиоэфиром, для лечения и профилактики инфекционного гепатита с | |
| JP2006515339A5 (https=) | ||
| JP2006524222A5 (https=) | ||
| RU2004121688A (ru) | 7-аминобензотиазольные производные в качестве лигандов аденозинового рецептора | |
| RU2004122129A (ru) | Производные индолилалкиламина в качестве лтгандов 5-гидрокситриптамина-6 | |
| JP2005513020A5 (https=) | ||
| JP2005527542A5 (https=) |