JP2025503448A5 - - Google Patents
Info
- Publication number
- JP2025503448A5 JP2025503448A5 JP2024536125A JP2024536125A JP2025503448A5 JP 2025503448 A5 JP2025503448 A5 JP 2025503448A5 JP 2024536125 A JP2024536125 A JP 2024536125A JP 2024536125 A JP2024536125 A JP 2024536125A JP 2025503448 A5 JP2025503448 A5 JP 2025503448A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- compound according
- acceptable form
- isotopic derivative
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2021/138744 WO2023108536A1 (en) | 2021-12-16 | 2021-12-16 | Tyk2 inhibitors and compositions and methods thereof |
| CNPCT/CN2021/138744 | 2021-12-16 | ||
| CNPCT/CN2022/106876 | 2022-07-20 | ||
| PCT/CN2022/106876 WO2023109120A1 (en) | 2021-12-16 | 2022-07-20 | Tyk2 inhibitors and compositions and methods thereof |
| PCT/CN2022/139649 WO2023109954A1 (en) | 2021-12-16 | 2022-12-16 | Tyk2 inhibitors and compositions and methods thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025503448A JP2025503448A (ja) | 2025-02-04 |
| JP2025503448A5 true JP2025503448A5 (OSRAM) | 2025-12-19 |
Family
ID=86774877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024536125A Pending JP2025503448A (ja) | 2021-12-16 | 2022-12-16 | Ｔｙｋ２阻害剤および組成物ならびにその方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US12129250B2 (OSRAM) |
| EP (1) | EP4448514A4 (OSRAM) |
| JP (1) | JP2025503448A (OSRAM) |
| KR (1) | KR20240120732A (OSRAM) |
| CN (1) | CN118401516A (OSRAM) |
| AU (1) | AU2022412835A1 (OSRAM) |
| CA (1) | CA3240888A1 (OSRAM) |
| IL (1) | IL313571A (OSRAM) |
| TW (1) | TW202339749A (OSRAM) |
| WO (1) | WO2023109954A1 (OSRAM) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN120303268A (zh) * | 2022-12-16 | 2025-07-11 | 津药生物科技（天津）有限公司 | 新型含杂环取代的丙烯酸衍生物及其用途 |
| CN120693328A (zh) * | 2023-02-07 | 2025-09-23 | 浙江华海药业股份有限公司 | 一种哒嗪类化合物、其制备方法和用途 |
| WO2024254832A1 (en) * | 2023-06-15 | 2024-12-19 | Lynk Pharmaceuticals Co. Ltd. | Tyk2 inhibitors and compositions and methods thereof |
| WO2026026866A1 (zh) * | 2024-08-02 | 2026-02-05 | 北京普祺医药科技股份有限公司 | 作为tyk2抑制剂的大环化合物及其药物组合物 |
| CN120607493B (zh) * | 2025-06-04 | 2026-04-24 | 江西科技师范大学 | 一种含嘧啶结构的酰胺类化合物及其在制备tyk2 jh2激酶抑制剂中的应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| US20060270694A1 (en) * | 2005-05-03 | 2006-11-30 | Rigel Pharmaceuticals, Inc. | JAK kinase inhibitors and their uses |
| CA2657260A1 (en) | 2006-07-21 | 2008-01-24 | Novartis Ag | 2, 4 -di (arylaminio) -pyrimidine-5-carboxamide compounds as jak kinases inhibitors |
| KR20100132550A (ko) | 2008-04-16 | 2010-12-17 | 포톨라 파마슈티컬스, 인코포레이티드 | ｓｙｋ 또는 ＪＡＫ 키나제 억제제로서의 ２,６－디아미노-피리미딘－５－일－카르복스아미드 |
| JP5705720B2 (ja) | 2008-04-16 | 2015-04-22 | ポートラ ファーマシューティカルズ， インコーポレイテッド | Ｓｙｋまたはｊａｋキナーゼ阻害剤としての２，６−ジアミノ−ピリミジン−５−イル−カルボキサミド |
| HRP20240097T1 (hr) | 2011-04-22 | 2024-03-29 | Signal Pharmaceuticals, Llc | Supstituirani diaminokarboksamid i diaminokarbonitril pirimidini, njihovi pripravci i postupci liječenja s njima |
| KR20140108594A (ko) | 2012-01-10 | 2014-09-11 | 에프. 호프만-라 로슈 아게 | 피리다진 아미드 화합물 및 syk 저해제로서의 이의 용도 |
| UY34807A (es) | 2012-05-16 | 2013-12-31 | Novartis Ag | Derivados monocíclicos de heteroarilcicloalquil- diamina |
| US9040530B2 (en) * | 2012-06-22 | 2015-05-26 | Portola Pharmaceuticals, Inc. | 1,2,4-triazine-6-carboxamide kinase inhibitors |
| AU2013341186B2 (en) | 2012-11-08 | 2017-03-30 | Bristol-Myers Squibb Company | Amide-substituted heterocyclic compounds useful as modulators of IL-12, IL-23 and/or IFN alpha responses |
| AR093403A1 (es) | 2012-11-08 | 2015-06-03 | Bristol Myers Squibb Co | COMPUESTOS DE PIRIDILO SUSTITUIDOS CON ALQUILAMIDA UTILES COMO MODULADORES DE LAS RESPUESTAS DE IL-12, IL23 Y/O INFa |
| JP2014198693A (ja) | 2013-03-29 | 2014-10-23 | 大鵬薬品工業株式会社 | 免疫疾患の予防及び／又は治療剤 |
| AR094537A1 (es) * | 2013-11-07 | 2015-08-12 | Bristol Myers Squibb Co | COMPUESTOS DE PIRIDILO SUSTITUIDOS CON ALQUILAMIDA ÚTILES COMO MODULADORES DE LAS RESPUESTAS DE IL-12, IL-23 Y/O IFNa |
| GB201717260D0 (en) | 2017-10-20 | 2017-12-06 | Galapagos Nv | Novel compounds and pharma ceutical compositions thereof for the treatment of inflammatory disorders |
| IL274816B2 (en) | 2017-11-21 | 2023-12-01 | Bristol Myers Squibb Co | Sulfone pyridine alkyl amide-substituted heteroaryl compounds |
| EP3768667B1 (en) * | 2018-03-22 | 2023-04-12 | Bristol-Myers Squibb Company | Heterocyclic compounds comprising pyridine useful as modulators of il-12, il-23 and/or ifn alpha responses |
| HRP20250048T1 (hr) * | 2018-10-22 | 2025-03-28 | Alumis Inc. | Inhibitori tyk2 i njihova uporaba |
| CA3118094A1 (en) | 2018-10-30 | 2020-05-07 | Bristol-Myers Squibb Company | Amide-substituted heterocyclic compounds for the treatment of conditions related to the modulation of il-12, il-23 and/or ifn-alpha |
| CN115448910B (zh) * | 2019-01-28 | 2024-04-19 | 江苏豪森药业集团有限公司 | 一种哒嗪类衍生物抑制剂、其制备方法和应用 |
| CN111484480B (zh) * | 2019-01-29 | 2023-08-11 | 上海翰森生物医药科技有限公司 | 一种多环类衍生物抑制剂、其制备方法和应用 |
| US20230093099A1 (en) * | 2019-04-02 | 2023-03-23 | Cullgen (Shanghai), Inc. | Compounds and methods of treating cancers |
| WO2021143498A1 (zh) * | 2020-01-19 | 2021-07-22 | 苏州科睿思制药有限公司 | 一种Deucravacitinib的晶型及其制备方法和用途 |
| HUE067219T2 (hu) * | 2020-03-11 | 2024-10-28 | Beijing Innocare Pharma Tech Co Ltd | Heterociklusos vegyületek a TYK2 aktivitás gátlására |
| TW202204344A (zh) * | 2020-04-01 | 2022-02-01 | 美商永恒生物科技公司 | 酪胺酸激酶2抑制劑、其製備方法及醫藥用途 |
| US20230295119A1 (en) * | 2020-04-14 | 2023-09-21 | Gossamer Bio Services, Inc. | Substituted pyridines for the treatment of inflammatory diseases |
| CN113563309B (zh) * | 2020-04-28 | 2024-12-13 | 浙江海正药业股份有限公司 | 吡啶类衍生物及其制备方法和用途 |
| US20220002267A1 (en) | 2020-06-24 | 2022-01-06 | Eternity Bioscience Inc. | Tyrosine kinase 2 inhibitors, preparation methods and medicinal uses thereof |
| CN113968846A (zh) | 2020-07-24 | 2022-01-25 | 上海翰森生物医药科技有限公司 | 一种哒嗪类衍生物的盐、晶型及其制备方法和应用 |
| JP2024504239A (ja) * | 2020-12-02 | 2024-01-31 | シェンチェン チップスクリーン バイオサイエンシズ カンパニー、リミテッド | ヒドロキサマート化合物、その調製方法及びその用途 |
| CN115197196B (zh) * | 2021-04-06 | 2024-06-18 | 扬子江药业集团有限公司 | Tyk2抑制剂及其用途 |
| TWI804266B (zh) * | 2021-04-07 | 2023-06-01 | 大陸商上海齊魯製藥研究中心有限公司 | Tyk2抑制劑及其用途 |
| US12509360B2 (en) | 2021-04-16 | 2025-12-30 | Sri Lanka Institute Of Information Technology | Method of making silver-iron titanate nanoparticles and uses thereof |
| CN115466257A (zh) * | 2021-06-11 | 2022-12-13 | 爱科诺生物医药(香港)有限公司 | 具有tyk2抑制活性的化合物，包含其的药物组合物，及其应用 |
-
2022
- 2022-12-16 JP JP2024536125A patent/JP2025503448A/ja active Pending
- 2022-12-16 CA CA3240888A patent/CA3240888A1/en active Pending
- 2022-12-16 KR KR1020247022401A patent/KR20240120732A/ko active Pending
- 2022-12-16 IL IL313571A patent/IL313571A/en unknown
- 2022-12-16 EP EP22906699.8A patent/EP4448514A4/en active Pending
- 2022-12-16 WO PCT/CN2022/139649 patent/WO2023109954A1/en not_active Ceased
- 2022-12-16 CN CN202280081287.8A patent/CN118401516A/zh active Pending
- 2022-12-16 AU AU2022412835A patent/AU2022412835A1/en active Pending
- 2022-12-16 TW TW111148445A patent/TW202339749A/zh unknown
-
2023
- 2023-09-25 US US18/372,417 patent/US12129250B2/en active Active
-
2024
- 2024-05-21 US US18/669,853 patent/US20250115597A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2024050527A5 (OSRAM) | ||
| JP2022510925A5 (OSRAM) | ||
| JP2022505525A5 (OSRAM) | ||
| JP2021523221A5 (OSRAM) | ||
| CN115697993A (zh) | 作为axl抑制剂的嘧啶类化合物 | |
| JP2022550640A5 (OSRAM) | ||
| CN114430739A (zh) | Egfr抑制剂、组合物及其制备方法 | |
| HRP20230909T1 (hr) | Spojevi inhibitori rip1 i postupci za njihovo dobivanje i upotrebu | |
| JP2019510787A5 (OSRAM) | ||
| JP2021523225A5 (OSRAM) | ||
| JP2021514001A5 (OSRAM) | ||
| JP2020510091A5 (OSRAM) | ||
| EP3013815B1 (en) | Carbazole carboxamide compounds useful as kinase inhibitors | |
| RU2003105805A (ru) | Производные 4-фенилпиридина в качестве антагонистов рецепторов нейрокинина-1 | |
| RU2008141368A (ru) | Новые гетероциклические соединения замещенного пиридина с антагонистической активностью схсr3 | |
| JP2015501833A5 (OSRAM) | ||
| JP2019531279A5 (OSRAM) | ||
| CA2418868A1 (en) | 4-phenyl-pyridine derivatives as neurokinin-1 receptor antagonists | |
| JP2022553376A5 (OSRAM) | ||
| JP2021502387A5 (OSRAM) | ||
| JP2024529527A5 (OSRAM) | ||
| JP2022552445A5 (OSRAM) | ||
| JP2022534704A5 (OSRAM) | ||
| JP2013542267A5 (OSRAM) | ||
| JP2021046404A5 (OSRAM) |