JP2025502615A - フェノキシおよびベンジルオキシ置換サイコプラストゲンならびにその使用 - Google Patents

フェノキシおよびベンジルオキシ置換サイコプラストゲンならびにその使用 Download PDF

Info

Publication number
JP2025502615A
JP2025502615A JP2024533215A JP2024533215A JP2025502615A JP 2025502615 A JP2025502615 A JP 2025502615A JP 2024533215 A JP2024533215 A JP 2024533215A JP 2024533215 A JP2024533215 A JP 2024533215A JP 2025502615 A JP2025502615 A JP 2025502615A
Authority
JP
Japan
Prior art keywords
compound
pharma
solvate
acceptable salt
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024533215A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2023114313A5 (https=
JP2025502615A5 (https=
Inventor
アーロン パウエル，ノエル
ヒチル，ミラン
Original Assignee
デリックス セラピューティクス，インク．
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by デリックス セラピューティクス，インク． filed Critical デリックス セラピューティクス，インク．
Publication of JP2025502615A publication Critical patent/JP2025502615A/ja
Publication of JPWO2023114313A5 publication Critical patent/JPWO2023114313A5/ja
Publication of JP2025502615A5 publication Critical patent/JP2025502615A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Addiction (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2024533215A 2021-12-15 2022-12-14 フェノキシおよびベンジルオキシ置換サイコプラストゲンならびにその使用 Pending JP2025502615A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163290036P 2021-12-15 2021-12-15
US63/290,036 2021-12-15
US202263387222P 2022-12-13 2022-12-13
US63/387,222 2022-12-13
PCT/US2022/052870 WO2023114313A1 (en) 2021-12-15 2022-12-14 Phenoxy and benzyloxy substituted psychoplastogens and uses thereof

Publications (3)

Publication Number Publication Date
JP2025502615A true JP2025502615A (ja) 2025-01-28
JPWO2023114313A5 JPWO2023114313A5 (https=) 2025-12-22
JP2025502615A5 JP2025502615A5 (https=) 2025-12-22

Family

ID=86773414

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024533215A Pending JP2025502615A (ja) 2021-12-15 2022-12-14 フェノキシおよびベンジルオキシ置換サイコプラストゲンならびにその使用

Country Status (10)

Country Link
US (2) US12295959B2 (https=)
EP (1) EP4448531A4 (https=)
JP (1) JP2025502615A (https=)
KR (1) KR20240150417A (https=)
AU (1) AU2022416279A1 (https=)
CA (1) CA3239565A1 (https=)
IL (1) IL313455A (https=)
MX (1) MX2024007221A (https=)
TW (1) TW202333668A (https=)
WO (1) WO2023114313A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202333668A (zh) 2021-12-15 2023-09-01 美商德利克斯醫療公司 經苯氧基及苄氧基取代之精神成形素(psychoplastogen)及其用途

Family Cites Families (188)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6515701A (https=) 1964-12-03 1966-06-06
US3525750A (en) 1966-05-31 1970-08-25 Geigy Chem Corp 1,2,3,4,5,6-hexahydro-azepino(4,5-b) indole derivatives
US3553232A (en) 1967-08-25 1971-01-05 Upjohn Co 4-(1,4,5,6-tetrahydroazepine(4,5-b)indole-3(2h)-yl)butyrophenones
US3637744A (en) 1969-04-04 1972-01-25 American Home Prod Indoleazocines
US3652588A (en) 1969-10-23 1972-03-28 Upjohn Co 6-alkyl-1 2 3 4 5 6-hexahydroazepino(4 5-b)indoles
DE3070467D1 (en) 1979-11-02 1985-05-15 Sandoz Ag Azepinoindoles, process for their production and pharmaceutical compositions containing them
US4581354A (en) 1984-08-06 1986-04-08 Sterling Drug Inc. 3-arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles, compositions and use
GB8419278D0 (en) 1984-07-27 1984-08-30 Lilly Industries Ltd Pharmaceutical compounds
DE3809155A1 (de) 1988-03-18 1989-09-28 Bayer Ag 1,3,4,5-tetrahydrobenz-(c,d)-indole
US5068234A (en) 1990-02-26 1991-11-26 Sterling Drug Inc. 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles
HUT61548A (en) 1990-08-27 1993-01-28 Sandoz Ag Process for producing indolonaphthyridine derivatives and pharmaceutical compositions comprising such compounds
FR2674522B1 (fr) 1991-03-26 1993-07-16 Lipha Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant.
DE4238994A1 (de) 1992-11-19 1994-05-26 Basf Ag Aniline als Markierungsmittel für Mineralöle
EP0620222A3 (en) 1993-04-14 1995-04-12 Lilly Co Eli Tetrahydro-beta-carbolines.
US5852046A (en) 1993-08-03 1998-12-22 Hoechst Aktiengesellschaft Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them
TW270114B (https=) 1993-10-22 1996-02-11 Hoffmann La Roche
CN1148340A (zh) 1994-03-11 1997-04-23 伊莱利利公司 治疗与5htzb受体有关病症的方法
GB9408577D0 (en) 1994-04-29 1994-06-22 Fujisawa Pharmaceutical Co New compound
RO115522B1 (ro) * 1995-02-02 2000-03-30 Smithkline Beecham P.L.C. Derivaţi de indolină, procedee pentru prepararea acestora, compoziţii farmaceutice care îi conţin şi metodă de tratament
US5843682A (en) 1995-11-20 1998-12-01 Boehringer Mannheim Corporation N-1-carboxyalkyl derivatives of LSD
GB9609641D0 (en) 1996-05-09 1996-07-10 Pfizer Ltd Compounds useful in therapy
AU6417198A (en) 1997-03-13 1998-09-29 Bioresearch Ireland a division of Eolas - The Irish Science and Technology Agency Cytoprotective agents comprising monoamine oxidase inhibitors
GB9819033D0 (en) 1998-09-01 1998-10-28 Cerebrus Ltd Chemical compounds VI
US6380242B1 (en) 1998-12-23 2002-04-30 Nps Allelix Corp. N-alkylamino-indoles for the treatment of migraine
PE20010052A1 (es) * 1999-04-23 2001-01-27 Upjohn Co Compuestos de azepinindol tetraciclico como agonistas o antagonistas del receptor de 5-ht
US6407092B1 (en) 1999-04-23 2002-06-18 Pharmacia & Upjohn Company Tetracyclic azepinoindole compounds
MXPA01012969A (es) 1999-06-15 2003-10-14 Bristol Myers Squibb Pharma Co Gamma-carbolinas fusionadas de heterociclo sustituido.
US7071186B2 (en) 1999-06-15 2006-07-04 Bristol-Myers Squibb Pharma Co. Substituted heterocycle fused gamma-carbolines
MY122278A (en) 1999-07-19 2006-04-29 Upjohn Co 1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position
BR0109193A (pt) 2000-03-17 2003-05-27 Alcon Inc Compostos com atividade agonista 5-ht2 e 5-ht1a para tratamento do glaucoma
AU2001269781A1 (en) 2000-07-06 2002-01-21 Pharmacia And Upjohn Company Substituted 2,3,7,8,9,10,11,12-octahydroazepino(4,5-b)pyrano(3,2-e) indoles
JP2004509074A (ja) 2000-07-06 2004-03-25 ファルマシア・アンド・アップジョン・カンパニー アゼピノ［４，５−ｂ］ピラノ［３，２−ｅ］インドール
ES2317923T3 (es) 2000-08-09 2009-05-01 Astrazeneca Ab Compuestos de cinolina.
WO2002012226A1 (en) 2000-08-09 2002-02-14 Astrazeneca Ab Quinoline derivatives having vegf inhibiting activity
US20070243240A9 (en) 2000-08-24 2007-10-18 Fred Windt-Hanke Transdermal therapeutic system
AU2001292898A1 (en) 2000-09-20 2002-04-02 Brad A. Acker Substituted azepino[4,5b)indole derivatives
EE200300303A (et) 2000-12-20 2003-12-15 Bristol-Myers Squibb Company Asendatud pürrolokinoliinid ja püridokinoliinid kui serotoniini agonistid ja antagonistid
PL366233A1 (en) 2000-12-20 2005-01-24 Bristol-Myers Squibb Company Substituted pyridoindoles as serotonin agonists and antagonists
ES2193839B1 (es) 2001-06-22 2005-02-16 Almirall Prodesfarma, S.A. Nuevos derivados de 6-fenildihidropirrolpirimidindiona.
AR038118A1 (es) 2002-01-14 2004-12-29 Upjohn Co Compuestos derivados de la bencinamida del acido 7-oxo-4,7-dihidrotien[2,3-b[piridin-6-carboxilico 3-sustituido que son utiles como antivirales
TWI329111B (en) 2002-05-24 2010-08-21 X Ceptor Therapeutics Inc Azepinoindole and pyridoindole derivatives as pharmaceutical agents
UA78999C2 (en) 2002-06-04 2007-05-10 Wyeth Corp 1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6
TW200400177A (en) 2002-06-04 2004-01-01 Wyeth Corp 1-(Aminoalkyl)-3-sulfonylindole and-indazole derivatives as 5-hydroxytryptamine-6 ligands
JPWO2004005389A1 (ja) 2002-07-09 2005-11-04 オリヱント化学工業株式会社 核効果抑制剤、結晶性樹脂組成物及び結晶性樹脂組成物の結晶化制御法
DK2009000T3 (da) 2003-01-16 2011-09-05 Acadia Pharm Inc Selektive serotonin 2A/2C-receptor invers-agonister som terapeutika for neurodegenerative sygdomme
US20050250767A1 (en) 2003-01-23 2005-11-10 Weiner David M Use of N-desmethylclozapine to treat human neuropsychiatric disease
WO2005005411A1 (en) 2003-07-04 2005-01-20 Glaxosmithkline S.P.A. Substituted indole ligands for the orl-1 receptor
EP1650206A4 (en) 2003-08-01 2006-12-20 Nippon Soda Co PHENYLAZOLE COMPOUNDS, PROCESS FOR THEIR PRODUCTION AND ANTIOXIDANTS
US8519158B2 (en) 2004-03-12 2013-08-27 Ligand Pharmaceuticals Incorporated Androgen receptor modulator compounds and methods
EP1632491A1 (en) * 2004-08-30 2006-03-08 Laboratorios Del Dr. Esteve, S.A. Substituted indole compounds and their use as 5-HT6 receptor modulators
GB0500492D0 (en) 2005-01-11 2005-02-16 Cyclacel Ltd Compound
CA2596015A1 (en) 2005-02-14 2006-08-24 Sampath K. Anandan Fused heterocyclic compounds useful as inhibitors of histone deacetylase
WO2007079239A2 (en) 2005-12-30 2007-07-12 Acadia Pharmaceuticals Inc. Bicyclic nitrogen compounds as modulators of ghrelin receptor and uses thereof
US7989447B2 (en) 2006-04-13 2011-08-02 Neuraxon, Inc. 1,5 and 3,6-substituted indole compounds having NOS inhibitory activity
KR102065319B1 (ko) 2007-03-12 2020-01-10 인트라-셀룰라 써래피스, 인코퍼레이티드. 치환된 헤테로환 융합 감마-카르볼린 합성
WO2008117935A1 (en) 2007-03-28 2008-10-02 Industry-Academic Cooperation Foundation, Yonsei University Nk cell activating molecules, nk cells and pharmaceutical compositons comprising the same
ES2763873T3 (es) 2007-06-21 2020-06-01 Veroscience Llc Método de tratamiento de trastornos metabólicos y depresión con agonistas del receptor de dopamina
US20100317863A1 (en) 2007-07-25 2010-12-16 Boehringer Ingelheim International Gmbh Glucocorticoid Mimetics, Methods of Making Them, Pharmaceutical Compositions and Uses Thereof
US8318813B2 (en) 2007-09-13 2012-11-27 Lcs Group, Llc Method of treating binge eating disorder
AR068509A1 (es) 2007-09-19 2009-11-18 Jerini Ag Antagosnistas del receptor de bradiquinina b1
RU2007139634A (ru) 2007-10-25 2009-04-27 Сергей Олегович Бачурин (RU) Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения
WO2009103022A1 (en) 2008-02-13 2009-08-20 Itherx Pharmaceuticals, Inc. Derivatives of substituted fused ring cycloindoles and methods of their use
TWI443098B (zh) 2008-03-24 2014-07-01 Medivation Technologies Inc 吡啶并〔３，４－ｂ〕吲哚及使用方法
WO2010051503A1 (en) 2008-10-31 2010-05-06 Medivation Technologies, Inc. Azepino [4, 5-b] indoles and methods of use
US9962368B2 (en) 2009-01-09 2018-05-08 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
EP2385829B1 (en) 2009-01-09 2018-08-01 Board of Regents of the University of Texas System Pro-neurogenic compounds
US8362277B2 (en) 2009-01-09 2013-01-29 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
US9162980B2 (en) 2009-01-09 2015-10-20 Board Of Regents Of The University Of Texas System Anti-depression compounds
US8637501B2 (en) 2009-07-01 2014-01-28 Albany Molecular Research, Inc. Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine MCH-1 antagonists, methods of making, and use thereof
US8367655B2 (en) 2009-07-03 2013-02-05 Daya Drug Discoveries, Inc. Pyridoindolobenzox—and thiazepine derivatives and uses thereof
CA2784894A1 (en) 2009-12-23 2011-06-30 Sanofi Indolyl-piperidinyl benzylamines as beta-tryptase inhibitors
CN107468211A (zh) 2010-01-18 2017-12-15 艾欧敏达有限公司 用于分析神经生理学数据的方法和系统以及评估系统
WO2012144972A2 (en) 2010-01-19 2012-10-26 The General Hospital Corporation Methods to inhibit neurodegeneration
US9034865B2 (en) 2010-02-18 2015-05-19 Medivation Technologies, Inc. Pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use
WO2011103485A1 (en) 2010-02-18 2011-08-25 Medivation Technologies, Inc. Fused tetracyclic pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use
WO2011103430A1 (en) 2010-02-19 2011-08-25 Medivation Technologies, Inc. Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use
US9393198B2 (en) 2010-03-22 2016-07-19 Signpath Pharma Inc. Intravenous curcumin and derivatives for treatment of neurodegenerative and stress disorders
WO2011123681A1 (en) 2010-03-31 2011-10-06 Rigel Pharmaceuticals, Inc. Methods for using carboxamide, sulfonamide and amine compounds
PH12012502079A1 (en) 2010-04-16 2013-02-11 Ac Immune Sa Novel compounds for the treatment of diseases associated with amyloid or amyloid-like proteins
US20140155384A1 (en) 2011-02-18 2014-06-05 Medivation Technologies, Inc. Compounds and methods of treating diabetes
US9035056B2 (en) 2011-02-18 2015-05-19 Medivation Technologies, Inc. Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use
CN103476417A (zh) 2011-02-18 2013-12-25 梅迪维新技术公司 治疗糖尿病的化合物和方法
US9434747B2 (en) 2011-02-18 2016-09-06 Medivation Technologies, Inc. Methods of treating diabetes
GB201111712D0 (en) 2011-07-08 2011-08-24 Gosforth Ct Holdings Pty Ltd Pharmaceutical compositions
US20130178618A1 (en) 2012-01-10 2013-07-11 William Allen Boulanger Novel pharmaceutical intermediates and methods for preparing the same
US10118943B2 (en) 2012-05-16 2018-11-06 Ramot At Tel-Aviv University Ltd. Compounds and methods for inhibiting cell death
CN102977091B (zh) 2012-11-06 2016-03-09 华东师范大学 芳香烷酰基四氢-β-咔啉及其衍生物在治疗代谢性疾病中的应用
CN102977092B (zh) 2012-11-06 2016-02-24 华东师范大学 芳香烷酰基四氢-β-咔啉及其衍生物在治疗恶性肿瘤中的应用
EP2981266B1 (en) 2013-03-04 2018-01-03 Daya CNS LLC Pentacyclic pyridoindolobenz[b,d]azepine derivatives and uses thereof
MX370188B (es) 2013-03-14 2019-12-04 Dart Neuroscience Cayman Ltd Compuestos de piridina y pirazina sustituidos como inhibidores de pde4.
NZ711598A (en) 2013-03-14 2016-09-30 Dart Neuroscience Cayman Ltd Substituted naphthyridine and quinoline compounds as mao inhibitors
US9292659B1 (en) 2014-10-29 2016-03-22 Heartflow, Inc. Systems and methods for vessel reactivity to guide diagnosis or treatment of cardiovascular disease
JP2017031088A (ja) 2015-07-31 2017-02-09 東レ株式会社 インドール誘導体及びその医薬用途
JP2019515643A (ja) 2015-09-23 2019-06-13 ミネルバ バイオテクノロジーズ コーポレーション 幹細胞分化剤のスクリーニング方法
JP2017100953A (ja) 2015-11-30 2017-06-08 東レ株式会社 テトラヒドロベンゾフロアゼピン誘導体及びその医薬用途
GB2550110A (en) 2016-04-28 2017-11-15 Univ Oxford Innovation Ltd Treatment of impulsivity-related disorders
JP7018026B2 (ja) 2016-06-16 2022-02-09 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト ヘテロアリールエストロゲン受容体モジュレーター及びその使用
US20180021326A1 (en) 2016-07-23 2018-01-25 Paul Edward Stamets Compositions and methods for enhancing neuroregeneration and cognition by combining mushroom extracts containing active ingredients psilocin or psilocybin with erinacines or hericenones enhanced with niacin
US11542315B2 (en) 2016-08-31 2023-01-03 Rutgers, The State University Of New Jersey Methods and compositions for treating diseases and disorders of the nervous system
WO2018064465A1 (en) 2016-09-29 2018-04-05 The Regents Of The University Of California Compounds for increasing neural plasticity
CA3105451A1 (en) 2017-05-12 2018-11-15 Indiana University Research And Technology Corporation Precision medicine for treating and preventing suicidality
US11845742B2 (en) 2017-11-14 2023-12-19 Rutgers, The State University Of New Jersey Therapeutic compounds and methods to treat infection
US10583123B2 (en) 2017-12-15 2020-03-10 National Tsing Hua University Method for the treatment of ATG4-related disorders
EA202092557A1 (ru) 2018-06-04 2021-04-01 Ас Иммьюн Са СОЕДИНЕНИЯ ТЕТРАГИДРОБЕНЗОФУРО[2,3-c]ПИРИДИНА И БЕТА-КАРБОЛИНА ДЛЯ ЛЕЧЕНИЯ, ОБЛЕГЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ РАССТРОЙСТВ, СВЯЗАННЫХ С АГРЕГАТАМИ ТАУ-БЕЛКА
MD3927338T2 (ro) 2019-02-22 2025-03-31 Gh Res Ireland Limited Compoziții cuprinzând 5-metoxi-N,N-dimetiltriptamină (5-MeO-DMT) pentru utilizare în tratarea tulburărilor mentale
AU2020228289B2 (en) 2019-02-27 2026-02-05 The Regents Of The University Of California N-substituted indoles and other heterocycles for treating brain disorders
CN113784962B (zh) 2019-02-27 2025-04-25 加利福尼亚大学董事会 用于治疗脑部疾病的氮杂环庚三烯并-吲哚类和其他杂环
PE20220166A1 (es) 2019-03-05 2022-01-28 F Star Therapeutics Inc Compuestos, composiciones y metodos para el tratamiento de enfermedad
EP4219498A1 (en) 2019-03-07 2023-08-02 Arbormentis LLC Compositions and methods of use comprising substances with neural plasticity actions administered at non-psychedelic / psychotomimetic dosages and formulations
US12522603B2 (en) 2019-03-13 2026-01-13 The Rockefeller University Inhibitors of gas for treating autoinflammatory diseases and cancer metastasis
WO2021003467A1 (en) 2019-07-04 2021-01-07 Sw Holdings, Inc. Metered dosing compositions and methods of use of psychedelic compounds
US20220273184A1 (en) 2019-08-20 2022-09-01 Terran Biosciences, Inc. Neuromelanin-sensitive mri for assessing parkinson's disease
US20230295106A1 (en) 2019-10-14 2023-09-21 The Regents Of The University Of California Ergoline-like compounds for promoting neural plasticity
WO2021178691A1 (en) 2020-03-05 2021-09-10 The Trustees Of Columbia University In The City Of New York Ibogaine analogs as therapeutics for neurological and psychiatric disorders
CN116075300B (zh) 2020-06-08 2025-08-05 泰科根公司 用于精神障碍或精神增强的有利苯并呋喃组合物
US20230227453A1 (en) 2020-06-10 2023-07-20 Delix Therapeutics, Inc. Tricyclic psychoplastogens and uses thereof
EP4185578A4 (en) 2020-07-20 2025-03-12 The Trustees Of Columbia University In The City Of New York IBOGAIN ANALOGUES AS THERAPEUTICS FOR NEUROLOGICAL AND PSYCHIATRIC DISEASES
JP2023540329A (ja) 2020-09-04 2023-09-22 ギルガメッシュ・ファーマシューティカルズ・インコーポレイテッド アゼチジニルトリプタミン及び精神障害を処置する方法
EP4216949A4 (en) 2020-09-28 2024-12-11 Yale University Selective agonists of 5-ht2a receptor and methods of use
CA3198609A1 (en) 2020-10-13 2022-04-21 The Regents Of The University Of California Gpcr screening method to identify non-hallucinogenic compounds
JP2023549712A (ja) 2020-11-16 2023-11-29 テラン バイオサイエンシズ， インコーポレイテッド ニューロメラニン感受性ｍｒｉ及びその使用方法
WO2022120181A1 (en) 2020-12-03 2022-06-09 Mydecine Innovations Group Inc. Novel psilocin analog compositions and methods of synthesizing the same
CN116917305A (zh) 2020-12-07 2023-10-20 明德赛特制药公司 用于治疗cns病症的作为血清素能剂的3-环状胺-吲哚衍生物
EP4126857A1 (en) 2021-01-15 2023-02-08 Beckley Psytech Limited Ergoline analogues
CA3207806A1 (en) 2021-02-08 2022-08-11 Dalibor Sames Oxa-ibogaine inspired analogues for treatment of neurological and psychiatric disorders
TW202304423A (zh) 2021-04-01 2023-02-01 美商泰仁生物科學公司 與致幻劑及血清素受體調節劑相關之方法及組合物
KR20230170053A (ko) 2021-04-13 2023-12-18 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 뇌 장애를 치료하기 위한 테트라사이클릭 화합물
WO2022235587A1 (en) 2021-05-03 2022-11-10 Terran Biosciences Inc. Lipid prodrugs of tryptamine and phenethylamine psychedelics and uses thereof
EP4347561A4 (en) 2021-05-26 2025-08-06 Bright Minds Biosciences Inc HETEROCYCLIC COMPOUNDS AND PROCESSES FOR THEIR PREPARATION
CA3225133A1 (en) 2021-07-07 2023-01-12 Matthew Alexander James Duncton N,n-dimethyltryptamine and related psychedlics and uses thereof
CA3225135A1 (en) 2021-07-07 2023-01-12 Sam CLARK 3,4-methylenedioxymethamphetamine and related psychedlics and uses thereof
WO2023018480A1 (en) 2021-08-09 2023-02-16 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Selective psychedelic compounds
WO2023018864A1 (en) 2021-08-12 2023-02-16 Psilosterics, Llc Hallucinogenic and non-hallucinogenic serotonin receptor agonists and methods of making and using the same
WO2023023298A1 (en) 2021-08-20 2023-02-23 Psilosterics, Llc Hallucinogenic and non-hallucinogenic compounds and methods of making and using the same
CA3229713A1 (en) 2021-08-20 2023-02-23 Terran Biosciences Inc. Deuterated analogs and derivatives of 4-bromo-2,5-dimethoxyphenethylamine and uses thereof
WO2023023347A1 (en) 2021-08-20 2023-02-23 Terran Biosciences Inc. Prodrugs and derivatives of psilocin and uses thereof
WO2023043794A1 (en) 2021-09-14 2023-03-23 Terran Biosciences Inc. Processes of preparing psilocin and psilocybin
US20230250098A1 (en) 2021-10-04 2023-08-10 University Of Health Sciences & Pharmacy In St. Louis Kratom opioid derivatives for the treatment of alcohol use disorder
WO2023059546A1 (en) 2021-10-04 2023-04-13 Psilosterics, Llc Serotonin receptor agonists and methods of making and using the same
WO2023073423A1 (en) 2021-10-26 2023-05-04 Diamond Therapeutics Inc. Ergoline-derived agonists of the 5-ht2a receptor
US20230159544A1 (en) 2021-10-29 2023-05-25 Terran Biosciences, Inc. Azepino-indoles for the treatment of neurological and psychiatric disorders
US20230159456A1 (en) 2021-10-29 2023-05-25 Terran Biosciences, Inc. N-substituted indoles
EP4426291A4 (en) 2021-11-03 2025-12-03 Tactogen Inc Indolizine compounds for the treatment of mental disorders or for mental improvement
US20250122164A1 (en) 2021-11-03 2025-04-17 The Regents Of The University Of California N,n-dimethylamphetamine analogs for treating brain disorders
WO2023081403A1 (en) 2021-11-05 2023-05-11 Terran Biosciences Inc. Isotopologes, salts, crystalline forms, stereoisomers, of methylone and ethylone and methods of use thereof
US20230150965A1 (en) 2021-11-05 2023-05-18 Terran Biosciences, Inc. Isotopically enriched n-methyl-1,3-benzodioxolylbutanamine (mbdb) and stereoisomers thereof
WO2023081895A1 (en) 2021-11-05 2023-05-11 Terran Biosciences, Inc. Isotopically enriched analogs of 5,6-methylenedioxy-2-aminoindane (mdai)
WO2023081892A1 (en) 2021-11-05 2023-05-11 Terran Biosciences, Inc. Analogs of n,n,n-trimethyl-4-phosphoryloxytryptamine
WO2023081897A1 (en) 2021-11-05 2023-05-11 Terran Biosciences, Inc. Isotopically enriched 3,4-methylenedioxy-n-ethylamphetamine (mde) and stereoisomers thereof
WO2023086962A1 (en) 2021-11-12 2023-05-19 Terran Biosciences Inc. Psilocybin and o-acetylpsilocin, salts and solid state forms thereof
US20230150920A1 (en) 2021-11-15 2023-05-18 Terran Biosciences, Inc. Salts and solid forms of 4-bromo-2,5-dimethoxyphenethylamine
US20240002337A1 (en) 2021-11-16 2024-01-04 Terran Biosciences Inc. Salts and solid forms of (r)-1-(5-methoxy-1h-indol-1-yl)-n,n-dimethylpropan-2-amine
WO2023092044A2 (en) 2021-11-17 2023-05-25 Terran Biosciences, Inc. Phenethylamine compounds salts, polymorphic forms and methods of use thereof
US20230257385A1 (en) 2021-11-17 2023-08-17 Terran Biosciences Inc. Salt and solid forms of tabernanthalog
JP2024544586A (ja) 2021-11-26 2024-12-03 ジ ユニバーシティ オブ ウェスタン オーストラリア Ｓｅｒｔ、ｄａｔ、および／またはｎｅｔ活性を調節するためのｍｄｍａの類縁体
WO2023107966A1 (en) 2021-12-06 2023-06-15 Terran Biosciences, Inc. Salt and solid forms of lysergic acid diethylamide (lsd) and analogs
WO2023107965A1 (en) 2021-12-06 2023-06-15 Terran Biosciences, Inc. Salt and solid forms of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (dom), 2,5-dimethoxy-4-iodoamphetamine (doi), 2,5-dimethoxy-4-bromoamphetamine (dob), and 2,5-dimethoxy-4-chloroamphetamine (doc)
WO2023107931A1 (en) 2021-12-06 2023-06-15 Terran Biosciences, Inc. Salt and solid forms of indole analogs and methods of use thereof
WO2023108174A1 (en) 2021-12-10 2023-06-15 Terran Biosciences, Inc. Analogs of 6-methoxy- n, n-dimethyltryptamine
JP2024546484A (ja) 2021-12-10 2024-12-24 ジーエーティーシー ヘルス コーポレーション 中毒および神経障害を治療する方法
WO2023108172A2 (en) 2021-12-11 2023-06-15 Terran Biosciences, Inc. Analogs of 4-substituted-2,5-dimethoxyamphetamine
WO2023114858A1 (en) 2021-12-15 2023-06-22 Delix Therapeutics, Inc. Benzofuran and benzothiophene psychoplastogens and uses thereof
CA3239571A1 (en) 2021-12-15 2023-06-22 Noel Aaron Powell Fused pyrrolidine psychoplastogens and uses thereof
TW202333668A (zh) 2021-12-15 2023-09-01 美商德利克斯醫療公司 經苯氧基及苄氧基取代之精神成形素(psychoplastogen)及其用途
EP4448518A4 (en) 2021-12-16 2025-12-17 Terran Biosciences Inc ISOTOPICALLY ENRICHED ANALOYS OF 2-BROM-LSD, LSD, ALD-52 AND 1P-LSD
EP4447954A4 (en) 2021-12-16 2025-12-03 Icahn School Med Mount Sinai HETEROCYCLIC COMPOUNDS AS POLARIZED 5HT2A AGONISTS
US20250049748A1 (en) 2021-12-16 2025-02-13 Terran Biosciences Inc. Analogs of 4-bromo-2,5-dimethoxyphenethylamine
WO2023115060A1 (en) 2021-12-17 2023-06-22 The Regents Of The University Of California Psychoplastogens for treating hearing-related disorders
WO2023122135A1 (en) 2021-12-22 2023-06-29 Kuleon Llc Serotonin receptor agonists and methods of making and using the same
JP2025501629A (ja) 2021-12-24 2025-01-22 サイロ プロプライエタリ リミテッド 化合物
CN118974044A (zh) 2021-12-24 2024-11-15 赛洛私人有限公司 化合物
EP4457203A4 (en) 2021-12-27 2025-12-17 Atai Therapeutics Inc AMINOTETRALINE ACTIVATORS OF SEROTONIN RECEPTORS
WO2023129976A1 (en) 2021-12-29 2023-07-06 Terran Biosciences, Inc. Salt and solid forms of ketanserin
WO2023133477A1 (en) 2022-01-06 2023-07-13 Terran Biosciences, Inc. Salts and solid forms of 4-hydroxy-n,n-diisopropyltryptamine hemi-glutarate and hemi-succinate
WO2023133524A1 (en) 2022-01-06 2023-07-13 Terran Biosciences, Inc. A process for synthesizing ketanserin
WO2023137446A1 (en) 2022-01-14 2023-07-20 Terran Biosciences Inc. Prodrugs of 3,4-methylenedioxy- n-ethyl-amphetamine (mdea) and uses thereof
US20250129054A1 (en) 2022-01-14 2025-04-24 Terran Biosciences Inc. Prodrugs of 3,4-methylenedioxy-n-methcathinone and uses thereof
US20250136548A1 (en) 2022-01-20 2025-05-01 Terran Biosciences Inc. Functionalized alkylamines
WO2023147423A1 (en) 2022-01-28 2023-08-03 Miralogx Llc Anxiolytic compounds, pharmaceutical compositions, and methods of treating anxiety and other disorders
US20250129064A1 (en) 2022-01-24 2025-04-24 Terran Biosciences Inc. Prodrugs of 2-bromo-lsd (2-bromolysergic acid diethylamide)
WO2023147424A1 (en) 2022-01-27 2023-08-03 Terran Biosciences, Inc. Salts and solid forms of n-ethyl-2-(5-fluoro-1h-indol-3-yl)- n-methylethan-1-amine
AU2023215456A1 (en) 2022-02-01 2024-08-01 Caamtech, Inc. Psychedelic compounds and their therapeutic uses
EP4479365A4 (en) 2022-02-16 2026-03-11 Terran Biosciences Inc IDAZOXAN DEUTERE AND ITS METHODS OF USE
US20250296934A1 (en) 2022-05-06 2025-09-25 Bright Minds Biosciences Inc. Azepinoindoles and methods of preparation thereof
US20240000795A1 (en) 2022-06-30 2024-01-04 Terran Biosciences Inc. Methods and compositions relating to controlling psychedelic effects with serotonin receptor modulators
CN117586171A (zh) 2022-08-12 2024-02-23 长春金赛药业有限责任公司 吲哚类衍生物、药物组合物及其在中枢神经领域的应用
CN117624169A (zh) 2022-08-24 2024-03-01 上海翊石医药科技有限公司 一类5-ht2a受体激动剂及其制备方法和应用
US20260078124A1 (en) 2022-09-12 2026-03-19 The Regents Of The University Of California Methods of preparing ergoline analogs

Also Published As

Publication number Publication date
US20250235463A1 (en) 2025-07-24
EP4448531A4 (en) 2025-12-24
IL313455A (en) 2024-08-01
KR20240150417A (ko) 2024-10-15
CA3239565A1 (en) 2023-06-22
MX2024007221A (es) 2024-08-27
EP4448531A1 (en) 2024-10-23
US12295959B2 (en) 2025-05-13
AU2022416279A1 (en) 2024-07-25
TW202333668A (zh) 2023-09-01
US20240335454A1 (en) 2024-10-10
WO2023114313A1 (en) 2023-06-22

Similar Documents

Publication Publication Date Title
WO2021076572A1 (en) Ergoline-like compounds for promoting neural plasticity
KR20230066543A (ko) 이소트립타민 사이코플라스토겐 및 이의 용도
JP2025502614A (ja) 縮合ピロリジンサイコプラストゲンとその使用
KR20230066311A (ko) 삼환형 사이코플라스토겐 및 이의 용도
PL201191B1 (pl) Piperazynowa pochodna i jej zastosowanie, zawierająca ją farmaceutyczna kompozycja oraz sposób wytwarzania piperazynowej pochodnej
US12295959B2 (en) Phenoxy and benzyloxy substituted psychoplastogens and uses thereof
US20250051276A1 (en) Aryloxy psychoplastogens and uses thereof
WO2023114858A1 (en) Benzofuran and benzothiophene psychoplastogens and uses thereof
WO2023114844A1 (en) Imidazopyridine psychoplastogens and uses thereof
CN118742551A (zh) 苯氧基和苄氧基取代的精神重塑剂及其用途
WO2023114325A1 (en) Constrained amine psychoplastogens and uses thereof
CN118696047A (zh) 稠合吡咯烷精神重塑剂及其用途
WO2024258995A2 (en) Fused tetrahydroazepine psychoplastogens and uses thereof
WO2024258988A2 (en) Serotonin releasing compounds and uses thereof
WO2025137596A1 (en) Mixed serotonin receptor binders for treatment of psychotic disorders
CN116507625A (zh) 异色胺神经可塑剂及其用途
WO2025137639A1 (en) Mixed serotonin receptor binders for treatment of psychotic disorders
WO2026072584A1 (en) Methods of using phenoxy and benzyloxy substituted neuroplastogens

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240731

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20251212

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20251212