JP2025501309A - 心肺障害の治療 - Google Patents

心肺障害の治療 Download PDF

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Publication number
JP2025501309A
JP2025501309A JP2024539926A JP2024539926A JP2025501309A JP 2025501309 A JP2025501309 A JP 2025501309A JP 2024539926 A JP2024539926 A JP 2024539926A JP 2024539926 A JP2024539926 A JP 2024539926A JP 2025501309 A JP2025501309 A JP 2025501309A
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JP
Japan
Prior art keywords
ethyl
formula
tetrahydroquinoline
phenyl
biphenyl
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Pending
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JP2024539926A
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English (en)
Japanese (ja)
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JP2025501309A5 (cg-RX-API-DMAC10.html
Inventor
エヴァ マリア ベッカー－ペルスター
ハンナ ティネル
ミヒャエル ハーン
ディーター ラング
ゲリット ヴァイマン
ヨハネス ナーゲルシュミッツ
リサ ディーツ
サウンドス サレー
ダビド ユング
イルディコ テレベシ
トビアス ムンドリー
アネット リヒター
ブリッタ オレニク
ビルギット カイル
ベルント レズラー
ペーター ファイ
ハイコ シルマー
ギド ベッカー
クレメンス ボーテ
ヘレーネ ファーベル
ユリアン エッガー
マーク パリー
デイビッド ワード
セシル ヴィトレ
Original Assignee
バイエル アクツィエンゲゼルシャフト
バイエル ファーマ アクツィエンゲゼルシャフト
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Application filed by バイエル アクツィエンゲゼルシャフト, バイエル ファーマ アクツィエンゲゼルシャフト filed Critical バイエル アクツィエンゲゼルシャフト
Publication of JP2025501309A publication Critical patent/JP2025501309A/ja
Publication of JP2025501309A5 publication Critical patent/JP2025501309A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Otolaryngology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2024539926A 2021-12-29 2022-12-28 心肺障害の治療 Pending JP2025501309A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21218165.5 2021-12-29
EP21218165 2021-12-29
PCT/EP2022/087954 WO2023126437A1 (en) 2021-12-29 2022-12-28 Treatment of cardiopulmonary disorders

Publications (2)

Publication Number Publication Date
JP2025501309A true JP2025501309A (ja) 2025-01-17
JP2025501309A5 JP2025501309A5 (cg-RX-API-DMAC10.html) 2026-01-08

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024539926A Pending JP2025501309A (ja) 2021-12-29 2022-12-28 心肺障害の治療

Country Status (11)

Country Link
US (2) US12138256B2 (cg-RX-API-DMAC10.html)
EP (1) EP4456896A1 (cg-RX-API-DMAC10.html)
JP (1) JP2025501309A (cg-RX-API-DMAC10.html)
KR (1) KR20240144178A (cg-RX-API-DMAC10.html)
CN (1) CN118765199A (cg-RX-API-DMAC10.html)
AU (1) AU2022424376A1 (cg-RX-API-DMAC10.html)
CA (1) CA3244895A1 (cg-RX-API-DMAC10.html)
IL (1) IL313920A (cg-RX-API-DMAC10.html)
MX (1) MX2024008170A (cg-RX-API-DMAC10.html)
TW (1) TW202342034A (cg-RX-API-DMAC10.html)
WO (1) WO2023126437A1 (cg-RX-API-DMAC10.html)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202342034A (zh) 2021-12-29 2023-11-01 德商拜耳廠股份有限公司 心肺病症之治療
AU2022429647A1 (en) 2021-12-29 2024-07-04 Bayer Aktiengesellschaft Process for preparing (5s)-{[2-(4-carboxyphenyl)ethyl] |2-(2-{|3-chloro-4'-(trifluoromethyl)biphenyl-4- yl]methoxy}phenyl)ethyl]aminol-5,6,7,8-tetrahydroquinoline-2-carboxylic acid and its crystalline forms for use as pharmaceutically active compound
CN118717697B (zh) * 2024-09-04 2025-03-25 杭州沐源生物医药科技有限公司 一种盐酸贝尼地平片组合物及其制备方法和应用
CN121714543A (zh) * 2024-09-23 2026-03-24 上海欣药智能科技有限公司 一种可吸入的含可溶性鸟苷酸环化酶受体激动剂的药物组合物及其用途

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TW202342035A (zh) 2021-12-29 2023-11-01 德商拜耳廠股份有限公司 醫藥乾粉吸入配製物
TW202342034A (zh) 2021-12-29 2023-11-01 德商拜耳廠股份有限公司 心肺病症之治療
AU2022429647A1 (en) 2021-12-29 2024-07-04 Bayer Aktiengesellschaft Process for preparing (5s)-{[2-(4-carboxyphenyl)ethyl] |2-(2-{|3-chloro-4'-(trifluoromethyl)biphenyl-4- yl]methoxy}phenyl)ethyl]aminol-5,6,7,8-tetrahydroquinoline-2-carboxylic acid and its crystalline forms for use as pharmaceutically active compound

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Publication number Publication date
CA3244895A1 (en) 2023-07-06
CN118765199A (zh) 2024-10-11
MX2024008170A (es) 2024-12-06
WO2023126437A1 (en) 2023-07-06
AU2022424376A1 (en) 2024-07-04
KR20240144178A (ko) 2024-10-02
IL313920A (en) 2024-08-01
EP4456896A1 (en) 2024-11-06
TW202342034A (zh) 2023-11-01
US12138256B2 (en) 2024-11-12
US20240148715A1 (en) 2024-05-09
US20250090519A1 (en) 2025-03-20

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