JP2025109839A5 - - Google Patents
Info
- Publication number
- JP2025109839A5 JP2025109839A5 JP2025080039A JP2025080039A JP2025109839A5 JP 2025109839 A5 JP2025109839 A5 JP 2025109839A5 JP 2025080039 A JP2025080039 A JP 2025080039A JP 2025080039 A JP2025080039 A JP 2025080039A JP 2025109839 A5 JP2025109839 A5 JP 2025109839A5
- Authority
- JP
- Japan
- Prior art keywords
- hla
- sla
- nucleotide sequences
- cells
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962924228P | 2019-10-22 | 2019-10-22 | |
| US62/924,228 | 2019-10-22 | ||
| US201962925859P | 2019-10-25 | 2019-10-25 | |
| US62/925,859 | 2019-10-25 | ||
| JP2022523593A JP7685249B2 (ja) | 2019-10-22 | 2020-10-22 | トランスジェニックブタ、その作製方法と用途、およびヒト免疫系マウスの作製方法 |
| PCT/US2020/056771 WO2021081156A1 (en) | 2019-10-22 | 2020-10-22 | Transgenic swine, methods of making and uses thereof, and methods of making human immune system mice |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022523593A Division JP7685249B2 (ja) | 2019-10-22 | 2020-10-22 | トランスジェニックブタ、その作製方法と用途、およびヒト免疫系マウスの作製方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025109839A JP2025109839A (ja) | 2025-07-25 |
| JP2025109839A5 true JP2025109839A5 (https=) | 2025-11-21 |
Family
ID=75620265
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022523593A Active JP7685249B2 (ja) | 2019-10-22 | 2020-10-22 | トランスジェニックブタ、その作製方法と用途、およびヒト免疫系マウスの作製方法 |
| JP2025080039A Pending JP2025109839A (ja) | 2019-10-22 | 2025-05-12 | トランスジェニックブタ、その作製方法と用途、およびヒト免疫系マウスの作製方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022523593A Active JP7685249B2 (ja) | 2019-10-22 | 2020-10-22 | トランスジェニックブタ、その作製方法と用途、およびヒト免疫系マウスの作製方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20220279767A1 (https=) |
| EP (1) | EP4048802A4 (https=) |
| JP (2) | JP7685249B2 (https=) |
| KR (1) | KR20220084296A (https=) |
| CN (1) | CN114585744A (https=) |
| AU (1) | AU2020370254B2 (https=) |
| CA (1) | CA3155234A1 (https=) |
| IL (1) | IL292406A (https=) |
| WO (1) | WO2021081156A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10883084B2 (en) | 2018-10-05 | 2021-01-05 | Xenotherapeutics, Inc. | Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non-human) donor and methods and products relating to same |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11510698A (ja) * | 1995-08-04 | 1999-09-21 | ザ ジェネラル ホスピタル コーポレイション | トランスジェニックブタ及びヒトｈｌａ遺伝子を有するブタ細胞 |
| US6639122B1 (en) * | 2000-09-19 | 2003-10-28 | Animal Technology Institute Taiwan | Transgenic swine having HLA-D gene, swine cells thereof and xenografts therefrom |
| WO2012092578A1 (en) * | 2010-12-31 | 2012-07-05 | The Trustees Of Columbia University In The City Of New York | Generation of autologous t-cells in mice |
| CA3205636A1 (en) * | 2011-04-20 | 2012-10-26 | University Of Washington Through Its Center For Commercialization | Beta-2 microglobulin-deficient cells |
| SMT202200205T1 (it) * | 2011-10-28 | 2022-07-21 | Regeneron Pharma | Topi geneticamente modificati che esprimono molecole chimeriche del complesso maggiore di istocompatibilità (mhc) ii |
| CN105578876B (zh) * | 2013-10-18 | 2018-07-13 | 大鹏药品工业株式会社 | 制备表达hlai类的非人动物的方法 |
| CN116059378A (zh) * | 2014-12-10 | 2023-05-05 | 明尼苏达大学董事会 | 用于治疗疾病的遗传修饰的细胞、组织和器官 |
| WO2016210280A1 (en) * | 2015-06-26 | 2016-12-29 | Indiana University Research & Technology Corporation | Transgenic pigs with genetic modifications of sla |
| US20190098879A1 (en) * | 2017-09-29 | 2019-04-04 | Regeneron Pharmaceuticals, Inc. | Non-Human Animals Comprising A Humanized TTR Locus And Methods Of Use |
| MX2021003866A (es) * | 2018-10-05 | 2021-09-08 | Xenotherapeutics Inc | Productos y metodos de xenotransplante. |
-
2020
- 2020-10-22 KR KR1020227012957A patent/KR20220084296A/ko active Pending
- 2020-10-22 WO PCT/US2020/056771 patent/WO2021081156A1/en not_active Ceased
- 2020-10-22 EP EP20880160.5A patent/EP4048802A4/en active Pending
- 2020-10-22 CA CA3155234A patent/CA3155234A1/en active Pending
- 2020-10-22 JP JP2022523593A patent/JP7685249B2/ja active Active
- 2020-10-22 IL IL292406A patent/IL292406A/en unknown
- 2020-10-22 CN CN202180005989.3A patent/CN114585744A/zh active Pending
- 2020-10-22 AU AU2020370254A patent/AU2020370254B2/en active Active
-
2022
- 2022-04-18 US US17/722,697 patent/US20220279767A1/en active Pending
-
2025
- 2025-05-12 JP JP2025080039A patent/JP2025109839A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2022162047A5 (https=) | ||
| JP2025109839A5 (https=) | ||
| Heijmans et al. | Comparative genetics of the major histocompatibility complex in humans and nonhuman primates | |
| US9861661B2 (en) | Elimination of immune responses to viral vectors | |
| Boyson et al. | Identification of a novel MHC class I gene, Mamu-AG, expressed in the placenta of a primate with an inactivated G locus | |
| US20240158464A1 (en) | Immunogenic peptides and their use in transplantation | |
| Desmond et al. | A systematic review of T-cell epitopes in hepatitis B virus: identification, genotypic variation and relevance to antiviral therapeutics | |
| EP2249864B1 (en) | Strategies to prevent and/or treat immune responses to soluble allofactors | |
| Le Bouteiller et al. | Antigen-presenting function (s) of the non-classical HLA-E,-F and-G class I molecules: the beginning of a story | |
| JP2023510872A5 (https=) | ||
| JP2015514421A5 (https=) | ||
| US20140370044A1 (en) | Modified epitopes for boosting cd4+ t-cell responses | |
| JP2017529841A5 (https=) | ||
| Mattson et al. | Differential effects of amino acid substitutions in the beta-sheet floor and alpha-2 helix of HLA-A2 on recognition by alloreactive viral peptide-specific cytotoxic T lymphocytes. | |
| CA2331846A1 (en) | Expression vectors for stimulating an immune response and methods of using the same | |
| JP2019507608A5 (https=) | ||
| JP2022547053A5 (https=) | ||
| Leiden et al. | The complete primary structure of the T-cell receptor genes from an alloreactive cytotoxic human T-lymphocyte clone | |
| Horwitz et al. | T-cell receptors from virus-specific cytotoxic T lymphocytes recognizing a single immunodominant nine-amino-acid viral epitope show marked diversity | |
| JP2022553328A5 (https=) | ||
| JP2022523024A5 (https=) | ||
| Schepart et al. | The nucleotide sequence and comparative analysis of the H-2Dp class I H-2 gene. | |
| Liu et al. | Major histocompatibility complex: Interaction with peptides | |
| Hermel et al. | Sequence divergence of B2m alleles of wild Mus musculus and Mus spretus implies positive selection | |
| Maziarz et al. | Recognition of interspecies hybrid class I histocompatibility antigens by antigen-specific cytolytic T lymphocytes. |