JP2025102784A5 - - Google Patents
Info
- Publication number
- JP2025102784A5 JP2025102784A5 JP2025034660A JP2025034660A JP2025102784A5 JP 2025102784 A5 JP2025102784 A5 JP 2025102784A5 JP 2025034660 A JP2025034660 A JP 2025034660A JP 2025034660 A JP2025034660 A JP 2025034660A JP 2025102784 A5 JP2025102784 A5 JP 2025102784A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- cas9 polypeptide
- terminal fragment
- cas9
- target
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962799702P | 2019-01-31 | 2019-01-31 | |
| US62/799,702 | 2019-01-31 | ||
| JP2021544294A JP7646552B2 (ja) | 2019-01-31 | 2020-01-31 | 低減された非標的脱アミノ化を有する核酸塩基エディターおよび核酸塩基エディターの特徴づけのためのアッセイ |
| PCT/US2020/016285 WO2020160514A1 (en) | 2019-01-31 | 2020-01-31 | Nucleobase editors having reduced non-target deamination and assays for characterizing nucleobase editors |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021544294A Division JP7646552B2 (ja) | 2019-01-31 | 2020-01-31 | 低減された非標的脱アミノ化を有する核酸塩基エディターおよび核酸塩基エディターの特徴づけのためのアッセイ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025102784A JP2025102784A (ja) | 2025-07-08 |
| JP2025102784A5 true JP2025102784A5 (cg-RX-API-DMAC7.html) | 2025-10-31 |
Family
ID=71842366
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021544294A Active JP7646552B2 (ja) | 2019-01-31 | 2020-01-31 | 低減された非標的脱アミノ化を有する核酸塩基エディターおよび核酸塩基エディターの特徴づけのためのアッセイ |
| JP2025034660A Pending JP2025102784A (ja) | 2019-01-31 | 2025-03-05 | 低減された非標的脱アミノ化を有する核酸塩基エディターおよび核酸塩基エディターの特徴づけのためのアッセイ |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021544294A Active JP7646552B2 (ja) | 2019-01-31 | 2020-01-31 | 低減された非標的脱アミノ化を有する核酸塩基エディターおよび核酸塩基エディターの特徴づけのためのアッセイ |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20220098572A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3918078A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP7646552B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20210121113A (cg-RX-API-DMAC7.html) |
| CN (1) | CN114040977B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2020215730A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3127493A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2020160514A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3204496A1 (en) | 2014-10-10 | 2017-08-16 | Editas Medicine, Inc. | Compositions and methods for promoting homology directed repair |
| CA3100019A1 (en) | 2018-05-11 | 2019-11-14 | Beam Therapeutics Inc. | Methods of substituting pathogenic amino acids using programmable base editor systems |
| EP3850088A4 (en) | 2018-09-07 | 2023-07-19 | Beam Therapeutics, Inc. | Compositions and methods for improving base editing |
| AU2021230546A1 (en) | 2020-03-04 | 2022-10-13 | Flagship Pioneering Innovations Vi, Llc | Methods and compositions for modulating a genome |
| US20230159913A1 (en) | 2020-04-28 | 2023-05-25 | The Broad Institute, Inc. | Targeted base editing of the ush2a gene |
| KR20230061474A (ko) * | 2020-09-04 | 2023-05-08 | 고쿠리츠다이가쿠호진 고베다이가쿠 | 소형화 시티딘 데아미나아제를 포함하는 이중쇄 dna의 개변용 복합체 |
| CN116601293A (zh) * | 2020-12-07 | 2023-08-15 | 中国科学院动物研究所 | 工程化的Cas效应蛋白及其使用方法 |
| CN112195164B (zh) * | 2020-12-07 | 2021-04-23 | 中国科学院动物研究所 | 工程化的Cas效应蛋白及其使用方法 |
| CA3214494A1 (en) * | 2021-03-26 | 2022-09-29 | Beam Therapeutics Inc. | Adenosine deaminase variants and uses thereof |
| CA3224970A1 (en) * | 2021-07-06 | 2023-01-12 | Holly A. REES | Compositions and methods for efficient genome editing |
| AU2022343268A1 (en) | 2021-09-08 | 2024-03-28 | Flagship Pioneering Innovations Vi, Llc | Methods and compositions for modulating a genome |
| US20250361530A1 (en) * | 2022-05-14 | 2025-11-27 | The Regents Of The University Of California | Genome editing systems for multiplexing point mutation introduction in living cells |
| CN119591727B (zh) * | 2023-12-06 | 2025-09-30 | 北京齐禾生科生物科技有限公司 | 优化的qbe碱基编辑系统及其应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150166982A1 (en) * | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting pi3k point mutations |
| WO2015089486A2 (en) * | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems |
| CN114438169B (zh) * | 2014-12-20 | 2024-11-08 | 阿克生物公司 | 使用CRISPR/Cas系统蛋白靶向消减、富集、和分割核酸的组合物及方法 |
| EP3250689B1 (en) * | 2015-01-28 | 2020-11-04 | The Regents of The University of California | Methods and compositions for labeling a single-stranded target nucleic acid |
| EP3303634B1 (en) * | 2015-06-03 | 2023-08-30 | The Regents of The University of California | Cas9 variants and methods of use thereof |
| WO2016205613A1 (en) * | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Crispr enzyme mutations reducing off-target effects |
| WO2017048969A1 (en) * | 2015-09-17 | 2017-03-23 | The Regents Of The University Of California | Variant cas9 polypeptides comprising internal insertions |
| SG11201803173VA (en) * | 2015-10-23 | 2018-05-30 | Harvard College | Nucleobase editors and uses thereof |
| JP7231935B2 (ja) * | 2016-08-03 | 2023-03-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | アデノシン核酸塩基編集因子およびそれらの使用 |
| SG10201913505WA (en) * | 2016-10-17 | 2020-02-27 | Univ Nanyang Tech | Truncated crispr-cas proteins for dna targeting |
| US10745677B2 (en) * | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
| KR20240116572A (ko) * | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| EP3625342B1 (en) | 2017-05-18 | 2022-08-24 | The Broad Institute, Inc. | Systems, methods, and compositions for targeted nucleic acid editing |
| AU2018290843B2 (en) * | 2017-06-26 | 2025-04-24 | Massachusetts Institute Of Technology | CRISPR/Cas-adenine deaminase based compositions, systems, and methods for targeted nucleic acid editing |
-
2020
- 2020-01-31 CA CA3127493A patent/CA3127493A1/en active Pending
- 2020-01-31 AU AU2020215730A patent/AU2020215730A1/en active Pending
- 2020-01-31 US US17/427,410 patent/US20220098572A1/en active Pending
- 2020-01-31 EP EP20748889.1A patent/EP3918078A4/en active Pending
- 2020-01-31 JP JP2021544294A patent/JP7646552B2/ja active Active
- 2020-01-31 CN CN202080026678.0A patent/CN114040977B/zh active Active
- 2020-01-31 KR KR1020217026724A patent/KR20210121113A/ko active Pending
- 2020-01-31 WO PCT/US2020/016285 patent/WO2020160514A1/en not_active Ceased
-
2025
- 2025-03-05 JP JP2025034660A patent/JP2025102784A/ja active Pending
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