JP2024546667A5 - - Google Patents
Info
- Publication number
- JP2024546667A5 JP2024546667A5 JP2024533904A JP2024533904A JP2024546667A5 JP 2024546667 A5 JP2024546667 A5 JP 2024546667A5 JP 2024533904 A JP2024533904 A JP 2024533904A JP 2024533904 A JP2024533904 A JP 2024533904A JP 2024546667 A5 JP2024546667 A5 JP 2024546667A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleotide
- nucleotide sequence
- sequence
- sirna
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111575800 | 2021-12-21 | ||
| CN202111575800.2 | 2021-12-21 | ||
| PCT/CN2022/139942 WO2023116607A1 (zh) | 2021-12-21 | 2022-12-19 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024546667A JP2024546667A (ja) | 2024-12-26 |
| JP2024546667A5 true JP2024546667A5 (https=) | 2025-12-24 |
Family
ID=86901326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024533904A Pending JP2024546667A (ja) | 2021-12-21 | 2022-12-19 | 核酸、当該核酸を含む組成物及び複合体並びに調製方法と使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20250057870A1 (https=) |
| EP (1) | EP4455284A1 (https=) |
| JP (1) | JP2024546667A (https=) |
| KR (1) | KR20240117104A (https=) |
| CN (1) | CN118202049A (https=) |
| AU (1) | AU2022422864A1 (https=) |
| CA (1) | CA3242059A1 (https=) |
| WO (1) | WO2023116607A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2020280439B2 (en) | 2019-05-22 | 2025-08-14 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use |
| KR20220011689A (ko) | 2019-05-22 | 2022-01-28 | 쑤저우 리보 라이프 사이언스 컴퍼니, 리미티드 | 핵산, 약제학적 조성물, 접합체, 제조 방법, 및 용도 |
| US12590304B2 (en) | 2019-05-22 | 2026-03-31 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use |
| CN113795582B (zh) | 2019-05-24 | 2024-05-24 | 苏州瑞博生物技术股份有限公司 | 核酸、药物组合物与缀合物及制备方法和用途 |
| CN121780524A (zh) * | 2024-08-02 | 2026-04-03 | 北京尧景基因技术有限公司 | 抑制MAPT基因表达的siRNA及其缀合物和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009143371A2 (en) * | 2008-05-21 | 2009-11-26 | Intradigm Corporation | COMPOSITIONS COMPRISING mTOR SIRNA AND METHODS OF USE THEREOF |
| WO2010064851A2 (ko) * | 2008-12-02 | 2010-06-10 | 울산대학교 산학협력단 | 종간 교차활성을 지닌 ｍＴＯＲ을 표적으로 하는 ｓｉＲＮＡ, 이를 포함하는 재조합벡터 및 이를 함유하는 약학조성물 |
| CN103380113B (zh) | 2010-11-15 | 2018-03-30 | 生命科技公司 | 含胺的转染试剂及其制备和使用方法 |
| US20190091256A1 (en) * | 2016-03-02 | 2019-03-28 | Beth Israel Deaconess Medical Center | Therapeutic targets for lin-28-expressing cancers |
| AU2018216509B2 (en) * | 2017-01-31 | 2024-02-29 | Curigin Co.,Ltd. | Nucleic acid simultaneously inhibiting expression of mTOR gene and STAT3 gene |
| TN2019000308A1 (en) | 2017-07-06 | 2021-05-07 | Arrowhead Pharmaceuticals Inc | RNAi AGENTS FOR INHIBITING EXPRESSION OF ALPHA-ENaC AND METHODS OF USE |
| CA3083970A1 (en) | 2017-12-01 | 2019-06-06 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate comprising the same, and preparation method and use thereof |
| AU2018394875B2 (en) | 2017-12-29 | 2023-08-03 | Suzhou Ribo Life Science Co., Ltd. | Conjugates and preparation and use thereof |
| MX2020011570A (es) | 2018-05-07 | 2020-11-24 | Alnylam Pharmaceuticals Inc | Administracion extrahepatica. |
| US12352767B2 (en) * | 2018-07-16 | 2025-07-08 | University Of Virginia Patent Foundation | Method of treating cognitive decline associated with neurological diseases based on a decrease in FLT4 expression or activity |
| WO2020135581A1 (zh) * | 2018-12-28 | 2020-07-02 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
-
2022
- 2022-12-19 KR KR1020247021150A patent/KR20240117104A/ko active Pending
- 2022-12-19 CA CA3242059A patent/CA3242059A1/en active Pending
- 2022-12-19 CN CN202280068763.2A patent/CN118202049A/zh active Pending
- 2022-12-19 WO PCT/CN2022/139942 patent/WO2023116607A1/zh not_active Ceased
- 2022-12-19 US US18/722,280 patent/US20250057870A1/en active Pending
- 2022-12-19 EP EP22909920.5A patent/EP4455284A1/en active Pending
- 2022-12-19 JP JP2024533904A patent/JP2024546667A/ja active Pending
- 2022-12-19 AU AU2022422864A patent/AU2022422864A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2024546667A5 (https=) | ||
| JP7008056B2 (ja) | 修飾されたサブユニット間結合および／または末端基を有するオリゴヌクレオチドアナログ | |
| US12037586B2 (en) | 4′-phosphate analogs and oligonucleotides comprising the same | |
| JP6884250B2 (ja) | ペプチドオリゴヌクレオチドコンジュゲート | |
| AU2017315670B2 (en) | Compositions comprising reversibly modified oligonucleotides and uses thereof | |
| KR101885383B1 (ko) | 신규한 핵산 프로드러그 및 그의 사용 방법 | |
| JP2009532044A5 (https=) | ||
| US20240368593A1 (en) | Gapmer oligonucleotides comprising a phosphorodithioate internucleoside linkage | |
| CN104011209A (zh) | 病毒基因表达的抑制 | |
| WO2021049504A1 (ja) | 肝臓送達用ＧａｌＮＡｃ－オリゴヌクレオチドコンジュゲートおよび製造方法 | |
| TW202309283A (zh) | 反義寡核苷酸及其用於治療神經變性障礙之用途 | |
| CN120118899A (zh) | 用于抑制MASP2表达的双链siRNA类似物及其制备方法和用途 | |
| CN111757936A (zh) | 包含二硫代磷酸酯核苷间连接的寡核苷酸 | |
| JP2022521510A (ja) | ホスホノアセテートギャップマー型オリゴヌクレオチド | |
| TW202600532A (zh) | 新穎核苷酸及寡核苷酸以及包含彼等之RNAi藥劑 | |
| JPWO2023112931A5 (https=) | ||
| HK40084990A (en) | 4'-oxymethylphosphonate nucleotide analogs and oligonucleotides comprising the same | |
| WO2022255273A1 (ja) | リガンド結合核酸複合体 | |
| WO2025264952A2 (en) | Novel rna therapeutics and uses thereof | |
| WO2025039996A1 (zh) | 抑制lpa基因表达的双链寡核苷酸及其应用 | |
| HK40033322A (zh) | 新的硫代亚磷酰胺 | |
| CN117897484A (zh) | 反义寡核苷酸及其用于治疗神经退行性障碍的用途 | |
| HK40033323A (en) | Gapmer oligonucleotides comprising a phosphorodithioate internucleoside linkage | |
| HK40037497A (en) | Oligonucleotides comprising a phosphorodithioate internucleoside linkage | |
| WO1996018640A1 (en) | Antisense nucleic acid homolog |