JP2024544123A - 特定のα，β－不飽和ケトンをエチニル化するプロセス - Google Patents

特定のα，β－不飽和ケトンをエチニル化するプロセス Download PDF

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JP2024544123A
JP2024544123A JP2024525885A JP2024525885A JP2024544123A JP 2024544123 A JP2024544123 A JP 2024544123A JP 2024525885 A JP2024525885 A JP 2024525885A JP 2024525885 A JP2024525885 A JP 2024525885A JP 2024544123 A JP2024544123 A JP 2024544123A
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branched
linear
formula
cyclic
substituted
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JP2024544123A5 (enExample
Inventor
ワーナー ボンラス，
ロルフ クエンジ，
ベレン ニエト－オルテガ，
ジョナサン， アラン メドロック，
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DSM IP Assets BV
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DSM IP Assets BV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/42—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing triple carbon-to-carbon bonds, e.g. with metal-alkynes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2024525885A 2021-12-17 2022-12-15 特定のα，β－不飽和ケトンをエチニル化するプロセス Pending JP2024544123A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21215524.6 2021-12-17
EP21215524 2021-12-17
PCT/EP2022/086014 WO2023111119A1 (en) 2021-12-17 2022-12-15 Process for ethynylating specific alpha, beta-unsaturated ketones

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JP2024544123A true JP2024544123A (ja) 2024-11-28
JP2024544123A5 JP2024544123A5 (enExample) 2025-06-13

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JP2024525885A Pending JP2024544123A (ja) 2021-12-17 2022-12-15 特定のα，β－不飽和ケトンをエチニル化するプロセス

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US (1) US20250059118A1 (enExample)
EP (1) EP4448474A1 (enExample)
JP (1) JP2024544123A (enExample)
CN (1) CN118401490A (enExample)
WO (1) WO2023111119A1 (enExample)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4320236A (en) * 1979-10-19 1982-03-16 Hoffmann-La Roche Inc. Ethynylation
JPH08176037A (ja) * 1994-10-13 1996-07-09 Basf Ag モノリチウムアセチリド／アンモニア錯体の製法及びα，β−不飽和ケトン及びアルデヒドをエチニル化する方法
WO2014078310A1 (en) * 2012-11-13 2014-05-22 Lyondell Chemical Technology, L.P. Process control with raman spectroscopy

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4320236A (en) * 1979-10-19 1982-03-16 Hoffmann-La Roche Inc. Ethynylation
JPH08176037A (ja) * 1994-10-13 1996-07-09 Basf Ag モノリチウムアセチリド／アンモニア錯体の製法及びα，β−不飽和ケトン及びアルデヒドをエチニル化する方法
WO2014078310A1 (en) * 2012-11-13 2014-05-22 Lyondell Chemical Technology, L.P. Process control with raman spectroscopy

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FU, T ET AL.: "Comparative immunogenicity evaluations of influenza A virus M2 peptide as recombinant virus like par", VACCINE, vol. 27, JPN6025010054, 2009, pages 1440 - 1447, ISSN: 0005813635 *
OROSHNIK, WILLIAM: "The Nef Reaction with α,β-Unsaturated Ketones", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 71, no. 6, JPN6026008748, 1949, pages 2062 - 2065, ISSN: 0005813633 *
RAMAN SPECTROSCOPY: BRINGING INLINE ANALYSIS TO PRODUCTION SPECTROSCOPY SUPPLEMENTS SPECTROSCOPY OUT, vol. s6(35), JPN6026008749, 2020, pages 30 - 34, ISSN: 0005813634 *

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WO2023111119A1 (en) 2023-06-22
US20250059118A1 (en) 2025-02-20
EP4448474A1 (en) 2024-10-23
CN118401490A (zh) 2024-07-26

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