JP2024535913A5 - - Google Patents
Info
- Publication number
- JP2024535913A5 JP2024535913A5 JP2024518869A JP2024518869A JP2024535913A5 JP 2024535913 A5 JP2024535913 A5 JP 2024535913A5 JP 2024518869 A JP2024518869 A JP 2024518869A JP 2024518869 A JP2024518869 A JP 2024518869A JP 2024535913 A5 JP2024535913 A5 JP 2024535913A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- aryl
- group
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111130589.3 | 2021-09-26 | ||
| CN202111130589.3A CN115869325A (zh) | 2021-09-26 | 2021-09-26 | 化合物用于制备治疗kras突变癌症患者的药物的用途 |
| PCT/CN2022/120817 WO2023046060A1 (zh) | 2021-09-26 | 2022-09-23 | 治疗kras突变的癌症患者 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024535913A JP2024535913A (ja) | 2024-10-02 |
| JP2024535913A5 true JP2024535913A5 (cg-RX-API-DMAC10.html) | 2025-09-26 |
Family
ID=85719305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024518869A Pending JP2024535913A (ja) | 2021-09-26 | 2022-09-23 | Ｋｒａｓ変異を有するがん患者の治療 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20250281514A1 (cg-RX-API-DMAC10.html) |
| EP (1) | EP4406538A4 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2024535913A (cg-RX-API-DMAC10.html) |
| KR (1) | KR20240067907A (cg-RX-API-DMAC10.html) |
| CN (2) | CN115869325A (cg-RX-API-DMAC10.html) |
| WO (1) | WO2023046060A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118804755A (zh) * | 2022-06-10 | 2024-10-18 | 深圳艾欣达伟医药科技有限公司 | Akr1c3酶激活前药治疗癌症患者的方法 |
| KR20260020475A (ko) | 2023-06-06 | 2026-02-11 | 아센타위츠 파마슈티컬즈 리미티드 | Akr1c3 효소 발현 수준과 kras 돌연변이의 상관관계 및 의학적 용도 |
| CN121985960A (zh) | 2023-10-18 | 2026-05-05 | 深圳艾欣达伟医药科技有限公司 | 治疗p53基因突变阴性、kras基因突变阳性、brca突变阳性患者 |
| WO2025140580A1 (zh) * | 2023-12-28 | 2025-07-03 | 深圳艾欣达伟医药科技有限公司 | 化合物晶型 |
| WO2026130539A1 (zh) * | 2024-12-20 | 2026-06-25 | 深圳艾欣达伟医药科技有限公司 | Akr1c3酶活化的化合物与免疫检查点抑制剂联用治疗癌症、肿瘤患者的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015053413A1 (ja) * | 2013-10-11 | 2015-04-16 | 千葉県 | ドライバーオンコジーンの遺伝子変異を標的にアルキル化する新規アルキル化剤 |
| WO2016145092A1 (en) | 2015-03-10 | 2016-09-15 | Threshold Pharmaceuticals, Inc. | Dna alkylating agents |
| WO2016161342A2 (en) | 2015-04-02 | 2016-10-06 | Threshold Pharmaceuticals, Inc. | Nitrobenzyl derivatives of anti-cancer agents |
| KR101985778B1 (ko) | 2015-11-16 | 2019-06-04 | 아센타위츠 파마슈티컬즈 리미티드 | (r)- 및 (s)-1-(3-(3-n,n-다이메틸아미노카보닐)페녹시-4-나이트로페닐)-1-에틸-n,n'-비스(에틸렌)포스포르아미데이트, 조성물 및 이의 사용 방법 및 제조 |
| CN110139741A (zh) | 2017-07-26 | 2019-08-16 | 北京阿迈特医疗器械有限公司 | 3d打印机及其打印方法 |
| TW201919644A (zh) | 2017-09-29 | 2019-06-01 | 台灣浩鼎生技股份有限公司 | 治療血癌的方法 |
| WO2019190331A1 (en) | 2018-03-29 | 2019-10-03 | Achilles Medical Limited | Prodrug compounds activated by akr1c3 and their use for treating hyperproliferative disorders |
| CN118834240A (zh) | 2019-05-13 | 2024-10-25 | 深圳艾欣达伟医药科技有限公司 | 含氟化合物及抗癌医药用途 |
| CN112220742A (zh) | 2019-07-15 | 2021-01-15 | 深圳艾欣达伟医药科技有限公司 | 稳定的ast-3424注射液制剂及制备方法 |
| WO2021043275A1 (zh) | 2019-09-05 | 2021-03-11 | 深圳艾欣达伟医药科技有限公司 | 注射液的包装瓶及包装套件、灌注加塞压盖装置和方法 |
| WO2021068952A1 (zh) | 2019-10-12 | 2021-04-15 | 南京明德新药研发有限公司 | 靶向醛酮还原酶1c3的苯并二氢吡喃类化合物 |
| CN118804755A (zh) * | 2022-06-10 | 2024-10-18 | 深圳艾欣达伟医药科技有限公司 | Akr1c3酶激活前药治疗癌症患者的方法 |
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2021
- 2021-09-26 CN CN202111130589.3A patent/CN115869325A/zh not_active Withdrawn
-
2022
- 2022-09-23 EP EP22872104.9A patent/EP4406538A4/en active Pending
- 2022-09-23 CN CN202280060627.9A patent/CN117956998A/zh active Pending
- 2022-09-23 JP JP2024518869A patent/JP2024535913A/ja active Pending
- 2022-09-23 KR KR1020247011060A patent/KR20240067907A/ko active Pending
- 2022-09-23 US US18/693,111 patent/US20250281514A1/en active Pending
- 2022-09-23 WO PCT/CN2022/120817 patent/WO2023046060A1/zh not_active Ceased