JP2024533371A5 - - Google Patents

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Publication number
JP2024533371A5
JP2024533371A5 JP2024515376A JP2024515376A JP2024533371A5 JP 2024533371 A5 JP2024533371 A5 JP 2024533371A5 JP 2024515376 A JP2024515376 A JP 2024515376A JP 2024515376 A JP2024515376 A JP 2024515376A JP 2024533371 A5 JP2024533371 A5 JP 2024533371A5
Authority
JP
Japan
Prior art keywords
formulas
nucleotides
nucleotide
nucleotide sequence
sina
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024515376A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024533371A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2022/042808 external-priority patent/WO2023039005A2/en
Publication of JP2024533371A publication Critical patent/JP2024533371A/ja
Publication of JP2024533371A5 publication Critical patent/JP2024533371A5/ja
Pending legal-status Critical Current

Links

JP2024515376A 2021-09-08 2022-09-07 修飾された短い干渉核酸（ｓｉＮＡ）分子及びそれらの使用 Pending JP2024533371A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163241935P 2021-09-08 2021-09-08
US63/241,935 2021-09-08
PCT/US2022/042808 WO2023039005A2 (en) 2021-09-08 2022-09-07 Modified short interfering nucleic acid (sina) molecules and uses thereof

Publications (2)

Publication Number Publication Date
JP2024533371A JP2024533371A (ja) 2024-09-12
JP2024533371A5 true JP2024533371A5 (https=) 2025-09-16

Family

ID=83506451

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024515376A Pending JP2024533371A (ja) 2021-09-08 2022-09-07 修飾された短い干渉核酸（ｓｉＮＡ）分子及びそれらの使用

Country Status (9)

Country Link
US (2) US12454691B2 (https=)
EP (1) EP4399217A2 (https=)
JP (1) JP2024533371A (https=)
KR (1) KR20240099159A (https=)
CN (1) CN118201942A (https=)
AU (1) AU2022344131A1 (https=)
CA (1) CA3231695A1 (https=)
TW (1) TW202320809A (https=)
WO (1) WO2023039005A2 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118271378A (zh) * 2022-12-29 2024-07-02 中国科学院深圳先进技术研究院 一种糖环修饰的核苷亚磷酰胺单体及其制备方法和应用
CN119836430A (zh) * 2023-05-12 2025-04-15 北京炫景瑞医药科技有限公司 修饰的核苷类似物及其用途与含核苷酸类似物的双链寡核苷酸及其用途
AU2024318590A1 (en) * 2023-07-31 2026-02-26 Basecure Therapeutics Inc. Conjugates of n-acetyl-galactosamine (galnac) and oligonucleotides and uses thereof
CN117534717A (zh) * 2024-01-09 2024-02-09 凯莱英生命科学技术(天津)有限公司 5′-(e)-乙烯基磷酸酯的合成方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2487716C2 (ru) * 2007-10-03 2013-07-20 Кварк Фармасьютикалс, Инк. Новые структуры малых интерферирующих рнк (sirna)
WO2011094953A1 (en) 2010-02-08 2011-08-11 F. Hoffmann-La Roche Ag Compounds for the treatment and prevention of influenza
WO2011139699A2 (en) * 2010-04-28 2011-11-10 Isis Pharmaceuticals, Inc. 5' modified nucleosides and oligomeric compounds prepared therefrom
EP2601204B1 (en) 2010-04-28 2016-09-07 Ionis Pharmaceuticals, Inc. Modified nucleosides and oligomeric compounds prepared therefrom
AU2014302711A1 (en) 2013-06-26 2015-12-10 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US10781175B2 (en) 2016-07-15 2020-09-22 Am Chemicals Llc Solid supports and phosphoramidite building blocks for oligonucleotide conjugates
SG11201901841TA (en) 2016-09-02 2019-03-28 Arrowhead Pharmaceuticals Inc Targeting ligands
HUE059718T2 (hu) 2016-09-02 2022-12-28 Dicerna Pharmaceuticals Inc 4'-foszfát analógok és azokat tartalmazó oligonukleotidok
EP3735252A4 (en) * 2018-01-04 2021-10-06 Avidity Biosciences, Inc. HETERODUPLEX NUCLEIC ACID MOLECULES AND USES THEREOF
WO2019217397A2 (en) * 2018-05-07 2019-11-14 Alnylam Pharmaceuticals, Inc. Compositions and methods for improving strand biased
PE20211783A1 (es) 2018-11-08 2021-09-08 Aligos Therapeutics Inc Polimeros oligonucleotidos que inhiben el transporte de antigenos y metodos
MX2021009717A (es) 2019-02-14 2021-09-14 Aligos Therapeutics Inc Sulfonamidas biciclicas.
MX2021012105A (es) 2019-04-03 2021-11-03 Aligos Therapeutics Inc Compuestos de pirrol.
AU2020260105A1 (en) 2019-04-17 2021-11-04 Aligos Therapeutics, Inc. Bicyclic and tricyclic compounds
US20240352464A1 (en) * 2023-03-07 2024-10-24 Aligos Therapeutics, Inc. Modified Short Interfering Nucleic Acid (siNA) Molecules and Uses Thereof

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