JP2024529068A - スルファミド誘導体、その調製方法及びその医薬的使用 - Google Patents

スルファミド誘導体、その調製方法及びその医薬的使用 Download PDF

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Publication number
JP2024529068A
JP2024529068A JP2024507166A JP2024507166A JP2024529068A JP 2024529068 A JP2024529068 A JP 2024529068A JP 2024507166 A JP2024507166 A JP 2024507166A JP 2024507166 A JP2024507166 A JP 2024507166A JP 2024529068 A JP2024529068 A JP 2024529068A
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group
general formula
cancer
salt
compound
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Japanese (ja)
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JP2024529068A5 (https=
Inventor
暁敏 張
偉民 胡
峰 賀
維康 陶
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Shanghai Hengrui Pharmaceutical Co Ltd
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Shanghai Hengrui Pharmaceutical Co Ltd
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Publication of JP2024529068A publication Critical patent/JP2024529068A/ja
Publication of JP2024529068A5 publication Critical patent/JP2024529068A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2024507166A 2021-08-10 2022-08-10 スルファミド誘導体、その調製方法及びその医薬的使用 Pending JP2024529068A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CN202110913249 2021-08-10
CN202110913249.1 2021-08-10
CN202111142090.4 2021-09-28
CN202111142090 2021-09-28
CN202111500231 2021-12-09
CN202111500231.5 2021-12-09
PCT/CN2022/111395 WO2023016484A1 (zh) 2021-08-10 2022-08-10 磺酰胺衍生物、其制备方法及其在医药上的应用

Publications (2)

Publication Number Publication Date
JP2024529068A true JP2024529068A (ja) 2024-08-01
JP2024529068A5 JP2024529068A5 (https=) 2025-08-19

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JP2024507166A Pending JP2024529068A (ja) 2021-08-10 2022-08-10 スルファミド誘導体、その調製方法及びその医薬的使用

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Country Link
US (1) US20250145637A1 (https=)
EP (1) EP4385989A4 (https=)
JP (1) JP2024529068A (https=)
KR (1) KR20240046530A (https=)
CN (1) CN117597341A (https=)
AU (1) AU2022325367A1 (https=)
CA (1) CA3228411A1 (https=)
MX (1) MX2024001777A (https=)
TW (1) TW202321263A (https=)
WO (1) WO2023016484A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118556053A (zh) 2021-11-16 2024-08-27 英矽智能科技知识产权有限公司 赖氨酸乙酰基转移酶6a(kat6a)抑制剂及其用途
WO2023114710A1 (en) * 2021-12-13 2023-06-22 Aurigene Oncology Limited Fused benzoisoxazolyl compounds as kat6a inhibitors
CN116621859A (zh) * 2022-02-18 2023-08-22 山东轩竹医药科技有限公司 三并环类kat6抑制剂
KR20250006833A (ko) 2022-03-28 2025-01-13 아이소스테릭스, 인코포레이티드 라이신 아세틸 전이효소의 myst 계열의 억제제
KR20250143814A (ko) * 2023-02-10 2025-10-02 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 설폰아미드 유도체 결정 형태 및 이의 제조 방법
WO2024189598A2 (en) 2023-03-16 2024-09-19 Olema Pharmaceuticals, Inc. Acylsulfonamide kat6a inhibitors
CN120981721A (zh) * 2023-03-30 2025-11-18 辉瑞大药厂 Kat6a作为用kat6a抑制剂治疗的预测性生物标志物和相关治疗方法
AU2024290895A1 (en) 2023-07-04 2026-01-29 Shanghai Qilu Pharmaceutical Research And Development Centre Ltd. Kat6 inhibitor
WO2025098417A1 (zh) * 2023-11-08 2025-05-15 再和医药科技（苏州）有限公司 磺酰胺类化合物及其应用
WO2025101942A1 (en) * 2023-11-10 2025-05-15 Prelude Therapeutics Incorporated Kat6 targeting compounds
AR134697A1 (es) * 2023-12-18 2026-03-04 Ideaya Biosciences Inc Compuestos químicos y sus usos

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06500794A (ja) * 1991-03-28 1994-01-27 エーザイ株式会社 複素環式−環式アミン誘導体
US20020028834A1 (en) * 1991-03-28 2002-03-07 Anabella Villalobos Heterocyclic-cyclic amine derivatives
WO2002074746A1 (en) * 2001-03-16 2002-09-26 Yamanouchi Pharmaceutical Co., Ltd. Benzazepine derivatives
JP2006507215A (ja) * 2002-02-22 2006-03-02 バイエル・フアーマシユーチカルズ・コーポレーシヨン 過剰増殖性障害の処置に有用なベンゾフランおよびベンゾチオフェン誘導体
JP2009504690A (ja) * 2005-08-18 2009-02-05 ゲンマブ エー／エス Ｃｄ４結合ペプチドおよび放射線による治療
JP2017508816A (ja) * 2014-03-20 2017-03-30 カペラ セラピューティクス，インコーポレーテッド 癌の治療のためのｅｒｂｂチロシンキナーゼ阻害剤としてのベンゾイミダゾール誘導体
WO2019243491A1 (en) * 2018-06-20 2019-12-26 Ctxt Pty Limited Compounds
WO2020048548A1 (zh) * 2018-09-07 2020-03-12 正大天晴药业集团股份有限公司 一种作用于crbn蛋白的三并环类化合物
WO2020254946A1 (en) * 2019-06-18 2020-12-24 Pfizer Inc. Benzisoxazole sulfonamide derivatives
WO2020254989A1 (en) * 2019-06-19 2020-12-24 Pfizer Inc. Cycloalkyl and heterocycloalkyl benzisoxazole sulfonamide derivatives

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105492430B (zh) * 2013-03-15 2017-10-10 基因泰克公司 取代的苯并噁唑及其使用方法
WO2015102929A1 (en) * 2013-12-30 2015-07-09 Novartis Ag Tricyclic sulfonamide derivatives
GB201510019D0 (en) 2015-06-09 2015-07-22 Cancer Therapeutics Crc Pty Ltd Compounds
WO2017218960A1 (en) 2016-06-17 2017-12-21 Fronthera U.S. Pharmaceuticals Llc Hemoglobin modifier compounds and uses thereof
GB201713962D0 (en) 2017-08-31 2017-10-18 Ctxt Pty Ltd Compounds
MX2020007131A (es) 2017-11-29 2021-01-08 Epizyme Inc Inhibidores de histona acetiltransferasa de la familia myst.
GB201810581D0 (en) 2018-06-28 2018-08-15 Ctxt Pty Ltd Compounds
EA202092908A1 (ru) 2018-09-28 2021-05-14 Праксис Пресижн Медсинз, Инк. Модуляторы ионных каналов
CA3137472A1 (en) 2019-04-25 2020-10-29 Bayer Aktiengesellschaft Acyl sulfonamides for treating cancer

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06500794A (ja) * 1991-03-28 1994-01-27 エーザイ株式会社 複素環式−環式アミン誘導体
US20020028834A1 (en) * 1991-03-28 2002-03-07 Anabella Villalobos Heterocyclic-cyclic amine derivatives
WO2002074746A1 (en) * 2001-03-16 2002-09-26 Yamanouchi Pharmaceutical Co., Ltd. Benzazepine derivatives
JP2006507215A (ja) * 2002-02-22 2006-03-02 バイエル・フアーマシユーチカルズ・コーポレーシヨン 過剰増殖性障害の処置に有用なベンゾフランおよびベンゾチオフェン誘導体
JP2009504690A (ja) * 2005-08-18 2009-02-05 ゲンマブ エー／エス Ｃｄ４結合ペプチドおよび放射線による治療
JP2017508816A (ja) * 2014-03-20 2017-03-30 カペラ セラピューティクス，インコーポレーテッド 癌の治療のためのｅｒｂｂチロシンキナーゼ阻害剤としてのベンゾイミダゾール誘導体
WO2019243491A1 (en) * 2018-06-20 2019-12-26 Ctxt Pty Limited Compounds
WO2020048548A1 (zh) * 2018-09-07 2020-03-12 正大天晴药业集团股份有限公司 一种作用于crbn蛋白的三并环类化合物
WO2020254946A1 (en) * 2019-06-18 2020-12-24 Pfizer Inc. Benzisoxazole sulfonamide derivatives
WO2020254989A1 (en) * 2019-06-19 2020-12-24 Pfizer Inc. Cycloalkyl and heterocycloalkyl benzisoxazole sulfonamide derivatives

Also Published As

Publication number Publication date
MX2024001777A (es) 2024-02-29
AU2022325367A1 (en) 2024-02-08
WO2023016484A1 (zh) 2023-02-16
CA3228411A1 (en) 2023-02-16
EP4385989A4 (en) 2024-12-18
CN117597341A (zh) 2024-02-23
KR20240046530A (ko) 2024-04-09
EP4385989A1 (en) 2024-06-19
US20250145637A1 (en) 2025-05-08
TW202321263A (zh) 2023-06-01

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