JP2024526334A - 肥大型心筋症を治療するための方法 - Google Patents
肥大型心筋症を治療するための方法 Download PDFInfo
- Publication number
- JP2024526334A JP2024526334A JP2024501787A JP2024501787A JP2024526334A JP 2024526334 A JP2024526334 A JP 2024526334A JP 2024501787 A JP2024501787 A JP 2024501787A JP 2024501787 A JP2024501787 A JP 2024501787A JP 2024526334 A JP2024526334 A JP 2024526334A
- Authority
- JP
- Japan
- Prior art keywords
- lvot
- compound
- lvef
- acceptable salt
- pharma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Display Devices Of Pinball Game Machines (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163203333P | 2021-07-16 | 2021-07-16 | |
| US63/203,333 | 2021-07-16 | ||
| US202263299753P | 2022-01-14 | 2022-01-14 | |
| US63/299,753 | 2022-01-14 | ||
| US202263305609P | 2022-02-01 | 2022-02-01 | |
| US63/305,609 | 2022-02-01 | ||
| US202263331197P | 2022-04-14 | 2022-04-14 | |
| US63/331,197 | 2022-04-14 | ||
| US202263343975P | 2022-05-19 | 2022-05-19 | |
| US63/343,975 | 2022-05-19 | ||
| PCT/US2022/073808 WO2023288324A1 (en) | 2021-07-16 | 2022-07-15 | Methods for treating hypertrophic cardiomyopathy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024526334A true JP2024526334A (ja) | 2024-07-17 |
| JP2024526334A5 JP2024526334A5 (https=) | 2025-07-23 |
Family
ID=82850823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024501787A Pending JP2024526334A (ja) | 2021-07-16 | 2022-07-15 | 肥大型心筋症を治療するための方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US20230058927A1 (https=) |
| EP (2) | EP4548912A3 (https=) |
| JP (1) | JP2024526334A (https=) |
| KR (1) | KR20240047359A (https=) |
| AU (1) | AU2022312506A1 (https=) |
| CA (1) | CA3225787A1 (https=) |
| CL (2) | CL2024000090A1 (https=) |
| DK (1) | DK4370116T3 (https=) |
| ES (1) | ES3014965T3 (https=) |
| FI (1) | FI4370116T3 (https=) |
| HR (1) | HRP20250174T1 (https=) |
| HU (1) | HUE070699T2 (https=) |
| IL (1) | IL310140A (https=) |
| LT (1) | LT4370116T (https=) |
| MX (1) | MX2024000804A (https=) |
| PL (1) | PL4370116T3 (https=) |
| PT (1) | PT4370116T (https=) |
| RS (1) | RS66640B1 (https=) |
| SI (1) | SI4370116T1 (https=) |
| SM (1) | SMT202500098T1 (https=) |
| TW (1) | TW202320763A (https=) |
| WO (1) | WO2023288324A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019144041A1 (en) | 2018-01-19 | 2019-07-25 | Cytokinetics, Inc. | Dihydrobenzofuran and inden analogs as cardiac sarcomere inhibitors |
| JP7610985B2 (ja) | 2018-06-26 | 2025-01-09 | サイトキネティックス， インコーポレイテッド | 心臓サルコメア阻害剤 |
| JP7438148B2 (ja) | 2018-06-26 | 2024-02-26 | サイトキネティックス， インコーポレイテッド | 心臓サルコメア阻害剤 |
| PT4370116T (pt) | 2021-07-16 | 2025-03-14 | Cytokinetics Inc | Regimes de administração de aficamten para o tratamento da cardiomiopatia hipertrófica obstrutiva |
| EP4565230A1 (en) * | 2022-08-04 | 2025-06-11 | Cytokinetics, Inc. | Methods for treating obstructive hypertrophic cardiomyopathy |
| WO2024182469A1 (en) * | 2023-02-28 | 2024-09-06 | MyoKardia, Inc. | Myosin inhibitors for use in the treatment of hypertrophic cardiomyopathy |
| WO2024179422A1 (zh) * | 2023-03-02 | 2024-09-06 | 苏州科睿思制药有限公司 | Aficamten的共晶及其制备方法和用途 |
| US20250295639A1 (en) | 2024-03-20 | 2025-09-25 | Cytokinetics, Incorporated | Methods for treating heart diseases |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060292695A1 (en) * | 2005-06-22 | 2006-12-28 | Roslin Institute | Methods and kits for drug screening and toxicity testing using promoter-reporter cells derived from embryonic stem cells |
| CA3071948A1 (en) * | 2017-08-04 | 2019-02-07 | MyoKardia, Inc. | Mavacamten for use in the treatment of hypertrophic cardiomyopathy |
| WO2019144041A1 (en) | 2018-01-19 | 2019-07-25 | Cytokinetics, Inc. | Dihydrobenzofuran and inden analogs as cardiac sarcomere inhibitors |
| WO2020257609A1 (en) | 2019-06-21 | 2020-12-24 | MyoKardia, Inc. | Diagnostics and treatments for cardiac disease |
| RS65302B1 (sr) | 2019-07-17 | 2024-04-30 | Cytokinetics Inc | Oralne formulacije inhibitora srčanog sarkomera |
| EP3999180B1 (en) | 2019-07-17 | 2024-05-08 | Cytokinetics, Inc. | Polymorphs of (r)-n-(5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1h-inden-1-yl)-1-methyl-1h-pyrazole-4-carboxamide |
| EP4054588A4 (en) | 2019-11-10 | 2023-12-13 | MyoKardia, Inc. | Methods of treatment with myosin modulator |
| MX2023002024A (es) | 2020-08-28 | 2023-05-10 | Myokardia Inc | Métodos de tratamiento con modulador de miosina. |
| CN114456163B (zh) | 2020-11-09 | 2023-08-11 | 江苏恒瑞医药股份有限公司 | 四氢吡啶并嘧啶二酮类衍生物、其制备方法及其在医药上的应用 |
| CN114516843B (zh) | 2020-11-19 | 2024-10-22 | 江苏恒瑞医药股份有限公司 | 嘧啶二酮类衍生物、其制备方法及其在医药上的应用 |
| WO2022105852A1 (zh) | 2020-11-20 | 2022-05-27 | 江苏恒瑞医药股份有限公司 | 三嗪二酮类衍生物、其制备方法及其在医药上的应用 |
| CN114539257B (zh) | 2020-11-24 | 2023-08-11 | 江苏恒瑞医药股份有限公司 | 嘧啶二酮类螺环衍生物、其制备方法及其在医药上的应用 |
| CN114539229B (zh) | 2020-11-24 | 2024-10-22 | 江苏恒瑞医药股份有限公司 | 嘧啶二酮类衍生物、其制备方法及其在医药上的应用 |
| CN116507621B (zh) | 2020-11-24 | 2025-10-17 | 江苏恒瑞医药股份有限公司 | 嘧啶二酮类衍生物、其制备方法及其在医药上的应用 |
| PT4370116T (pt) | 2021-07-16 | 2025-03-14 | Cytokinetics Inc | Regimes de administração de aficamten para o tratamento da cardiomiopatia hipertrófica obstrutiva |
| MX2024001294A (es) | 2021-08-03 | 2024-02-13 | Cytokinetics Inc | Proceso para la preparacion de aficamten. |
| EP4514355A1 (en) | 2022-04-26 | 2025-03-05 | MyoKardia, Inc. | Methods of administering myosin inhibitors |
| WO2024020468A1 (en) | 2022-07-20 | 2024-01-25 | Cytokinetics, Incorporated | Methods for treating non-obstructive hypertrophic cardiomyopathy |
| EP4565230A1 (en) | 2022-08-04 | 2025-06-11 | Cytokinetics, Inc. | Methods for treating obstructive hypertrophic cardiomyopathy |
| WO2024050139A1 (en) | 2022-09-02 | 2024-03-07 | AnaBios Corporation | Therapeutic uses of cardiac myosin inhibitors |
| CN120187352A (zh) | 2022-10-21 | 2025-06-20 | 普若莱奥公司 | 治疗肥厚型心肌病的系统和方法 |
| WO2024097284A1 (en) | 2022-11-02 | 2024-05-10 | MyoKardia, Inc. | Mavacamten and derivatives thereof for use in treating atrial dysfunction |
| WO2024134498A1 (en) | 2022-12-22 | 2024-06-27 | Assia Chemical Industries Ltd. | Solid state forms of aficamten and process for preparation thereof |
| WO2024173765A1 (en) | 2023-02-17 | 2024-08-22 | Bristol Myers Squibb Company | Methods of prognosis and treatment for heart failure with preserved ejection fraction using urinary protein levels |
| WO2024182469A1 (en) | 2023-02-28 | 2024-09-06 | MyoKardia, Inc. | Myosin inhibitors for use in the treatment of hypertrophic cardiomyopathy |
| WO2024179422A1 (zh) | 2023-03-02 | 2024-09-06 | 苏州科睿思制药有限公司 | Aficamten的共晶及其制备方法和用途 |
| WO2025096779A2 (en) | 2023-11-01 | 2025-05-08 | Bristol Myers Squibb Company | Methods of treatment with a myosin inhibitor using protein levels |
-
2022
- 2022-07-15 PT PT227539533T patent/PT4370116T/pt unknown
- 2022-07-15 LT LTEPPCT/US2022/073808T patent/LT4370116T/lt unknown
- 2022-07-15 FI FIEP22753953.3T patent/FI4370116T3/fi active
- 2022-07-15 EP EP25151678.7A patent/EP4548912A3/en active Pending
- 2022-07-15 AU AU2022312506A patent/AU2022312506A1/en active Pending
- 2022-07-15 HR HRP20250174TT patent/HRP20250174T1/hr unknown
- 2022-07-15 PL PL22753953.3T patent/PL4370116T3/pl unknown
- 2022-07-15 MX MX2024000804A patent/MX2024000804A/es unknown
- 2022-07-15 IL IL310140A patent/IL310140A/en unknown
- 2022-07-15 CA CA3225787A patent/CA3225787A1/en active Pending
- 2022-07-15 WO PCT/US2022/073808 patent/WO2023288324A1/en not_active Ceased
- 2022-07-15 JP JP2024501787A patent/JP2024526334A/ja active Pending
- 2022-07-15 HU HUE22753953A patent/HUE070699T2/hu unknown
- 2022-07-15 DK DK22753953.3T patent/DK4370116T3/da active
- 2022-07-15 SM SM20250098T patent/SMT202500098T1/it unknown
- 2022-07-15 KR KR1020247002855A patent/KR20240047359A/ko active Pending
- 2022-07-15 SI SI202230095T patent/SI4370116T1/sl unknown
- 2022-07-15 US US17/812,994 patent/US20230058927A1/en not_active Abandoned
- 2022-07-15 EP EP22753953.3A patent/EP4370116B1/en active Active
- 2022-07-15 TW TW111126631A patent/TW202320763A/zh unknown
- 2022-07-15 ES ES22753953T patent/ES3014965T3/es active Active
- 2022-07-15 RS RS20250239A patent/RS66640B1/sr unknown
-
2024
- 2024-01-10 CL CL2024000090A patent/CL2024000090A1/es unknown
- 2024-06-25 CL CL2024001945A patent/CL2024001945A1/es unknown
- 2024-10-08 US US18/909,401 patent/US12370179B1/en active Active
- 2024-10-15 US US18/916,215 patent/US20250177357A1/en active Pending
-
2025
- 2025-07-01 US US19/257,352 patent/US20260097021A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| PL4370116T3 (pl) | 2025-04-28 |
| EP4370116B1 (en) | 2025-01-15 |
| HUE070699T2 (hu) | 2025-06-28 |
| MX2024000804A (es) | 2024-02-06 |
| CA3225787A1 (en) | 2023-01-19 |
| RS66640B1 (sr) | 2025-04-30 |
| SI4370116T1 (sl) | 2025-04-30 |
| US20250177357A1 (en) | 2025-06-05 |
| FI4370116T3 (fi) | 2025-03-04 |
| CL2024001945A1 (es) | 2024-12-06 |
| SMT202500098T1 (it) | 2025-03-12 |
| DK4370116T3 (da) | 2025-02-03 |
| IL310140A (en) | 2024-03-01 |
| KR20240047359A (ko) | 2024-04-12 |
| EP4548912A3 (en) | 2025-07-02 |
| CL2024000090A1 (es) | 2024-08-16 |
| AU2022312506A1 (en) | 2024-02-01 |
| EP4370116A1 (en) | 2024-05-22 |
| US12370179B1 (en) | 2025-07-29 |
| WO2023288324A1 (en) | 2023-01-19 |
| PT4370116T (pt) | 2025-03-14 |
| LT4370116T (lt) | 2025-04-10 |
| ES3014965T3 (en) | 2025-04-28 |
| US20260097021A1 (en) | 2026-04-09 |
| EP4548912A2 (en) | 2025-05-07 |
| HRP20250174T1 (hr) | 2025-04-11 |
| TW202320763A (zh) | 2023-06-01 |
| US20230058927A1 (en) | 2023-02-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2024526334A (ja) | 肥大型心筋症を治療するための方法 | |
| JP2025523921A (ja) | 非閉塞性肥大型心筋症を治療するための方法 | |
| JP2020529996A (ja) | 肥大型心筋症の治療で使用するためのマバカムテン | |
| CN102056603A (zh) | 决奈达隆用于预防持续性心房纤颤 | |
| JP2025525913A (ja) | 閉塞性肥大型心筋症を治療するための方法 | |
| WO2024081611A1 (en) | Methods for treating heart failure by administering cardiac sarcomere activators | |
| WO2024097284A1 (en) | Mavacamten and derivatives thereof for use in treating atrial dysfunction | |
| HK40110429B (en) | Aficamten dosage regimens for treating obstructive hypertrophic cardiomyopathy | |
| HK40110429A (en) | Aficamten dosage regimens for treating obstructive hypertrophic cardiomyopathy | |
| HK40105016A (zh) | 用於治疗肥厚型心肌病的方法 | |
| CN117794535A (zh) | 用于治疗肥厚型心肌病的方法 | |
| HK40122885A (zh) | 用於治疗阻塞性肥厚性心肌病的方法 | |
| HK40122886A (zh) | 用於治疗非阻塞性肥厚性心肌病的方法 | |
| US20250295639A1 (en) | Methods for treating heart diseases | |
| JP7439297B2 (ja) | 肥大型心筋症治療用薬学組成物およびその組成物を用いた治療方法 | |
| Kistler et al. | Management of atrial fibrillation | |
| AU2022290589A1 (en) | Safe administration of mmp-12 inhibitor | |
| WO2008134602A1 (en) | Levosimendan dosage regimen | |
| Christmas et al. | Perioperative Cardiovascular Evaluation and Treatment of Elderly Patients Undergoing Noncardiac Surgery |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20250714 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20250714 |