JP2024524658A - ４－（（ｒ）－２－｛［６－（（ｓ）－３－メトキシ－ピロリジン－１－イル）－２－フェニル－ピリミジン－４－カルボニル］－アミノ｝－３－ホスホノ－プロピオニル）－ピペラジン－１－カルボン酸ブチルエステルの合成方法 - Google Patents

４－（（ｒ）－２－｛［６－（（ｓ）－３－メトキシ－ピロリジン－１－イル）－２－フェニル－ピリミジン－４－カルボニル］－アミノ｝－３－ホスホノ－プロピオニル）－ピペラジン－１－カルボン酸ブチルエステルの合成方法 Download PDF

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JP2024524658A
JP2024524658A JP2024501708A JP2024501708A JP2024524658A JP 2024524658 A JP2024524658 A JP 2024524658A JP 2024501708 A JP2024501708 A JP 2024501708A JP 2024501708 A JP2024501708 A JP 2024501708A JP 2024524658 A JP2024524658 A JP 2024524658A
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compound
hcl
amount
mixture
water
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Japanese (ja)
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JP2024524658A5 (https=
Inventor
ブルメール ニコル
クラヴォー ロマン
フェイアン ファビアン
ホール リアン
ヒューズ スティーブン
リーバー ステファン
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Idorsia Pharmaceuticals Ltd
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Idorsia Pharmaceuticals Ltd
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Publication of JP2024524658A publication Critical patent/JP2024524658A/ja
Publication of JP2024524658A5 publication Critical patent/JP2024524658A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2024501708A 2021-07-13 2022-07-11 ４－（（ｒ）－２－｛［６－（（ｓ）－３－メトキシ－ピロリジン－１－イル）－２－フェニル－ピリミジン－４－カルボニル］－アミノ｝－３－ホスホノ－プロピオニル）－ピペラジン－１－カルボン酸ブチルエステルの合成方法 Pending JP2024524658A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EPPCT/EP2021/069486 2021-07-13
EP2021069486 2021-07-13
PCT/EP2022/069238 WO2023285342A2 (en) 2021-07-13 2022-07-11 A process for the synthesis of 4-((r)-2-{[6-((s)-3-methoxy-pyrrolidin-1-yl)-2-phenyl- pyrimidine-4-carbonyl]-amino}-3-phosphono-propionyl)-piperazine-1 -carboxylic acid butyl ester

Publications (2)

Publication Number Publication Date
JP2024524658A true JP2024524658A (ja) 2024-07-05
JP2024524658A5 JP2024524658A5 (https=) 2025-07-02

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ID=82748669

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JP2024501708A Pending JP2024524658A (ja) 2021-07-13 2022-07-11 ４－（（ｒ）－２－｛［６－（（ｓ）－３－メトキシ－ピロリジン－１－イル）－２－フェニル－ピリミジン－４－カルボニル］－アミノ｝－３－ホスホノ－プロピオニル）－ピペラジン－１－カルボン酸ブチルエステルの合成方法

Country Status (10)

Country Link
US (1) US20240317784A1 (https=)
EP (1) EP4370525A2 (https=)
JP (1) JP2024524658A (https=)
KR (1) KR20240033005A (https=)
CN (1) CN117616033A (https=)
CA (1) CA3223733A1 (https=)
IL (1) IL309948A (https=)
MX (1) MX2024000653A (https=)
TW (1) TW202317140A (https=)
WO (1) WO2023285342A2 (https=)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011505352A (ja) * 2007-11-29 2011-02-24 アクテリオン ファーマシューティカルズ リミテッド ホスホン酸誘導体及びｐ２ｙ１２受容体拮抗剤としてのそれらの使用
JP2019529553A (ja) * 2016-09-22 2019-10-17 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ 結晶形

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA49887A (fr) 2017-03-15 2020-06-24 Idorsia Pharmaceuticals Ltd Administration sous-cutanée d'un antagoniste du récepteur p2y12

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011505352A (ja) * 2007-11-29 2011-02-24 アクテリオン ファーマシューティカルズ リミテッド ホスホン酸誘導体及びｐ２ｙ１２受容体拮抗剤としてのそれらの使用
JP2019529553A (ja) * 2016-09-22 2019-10-17 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ 結晶形

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
平山令明, 有機化合物結晶作製ハンドブック, JPN6014035600, 2008, pages 17 - 23, ISSN: 0005834964 *
浅原 照三ほか編, 溶剤ハンドブック, JPN6011026738, 1985, ISSN: 0005834965 *

Also Published As

Publication number Publication date
KR20240033005A (ko) 2024-03-12
IL309948A (en) 2024-03-01
WO2023285342A3 (en) 2023-04-13
WO2023285342A2 (en) 2023-01-19
TW202317140A (zh) 2023-05-01
CN117616033A (zh) 2024-02-27
CA3223733A1 (en) 2023-01-19
EP4370525A2 (en) 2024-05-22
US20240317784A1 (en) 2024-09-26
MX2024000653A (es) 2024-01-31

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