KR20240033005A - 4-((r)-2-｛[6-((s)-3-메톡시-피롤리딘-1-일)-2-페닐-피리미딘-4-카르보닐]-아미노｝-3-포스포노-프로피오닐)-피페라진-1-카르복실산부틸 에스테르의 합성 방법 - Google Patents

4-((r)-2-｛[6-((s)-3-메톡시-피롤리딘-1-일)-2-페닐-피리미딘-4-카르보닐]-아미노｝-3-포스포노-프로피오닐)-피페라진-1-카르복실산부틸 에스테르의 합성 방법 Download PDF

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Publication number
KR20240033005A
KR20240033005A KR1020247004672A KR20247004672A KR20240033005A KR 20240033005 A KR20240033005 A KR 20240033005A KR 1020247004672 A KR1020247004672 A KR 1020247004672A KR 20247004672 A KR20247004672 A KR 20247004672A KR 20240033005 A KR20240033005 A KR 20240033005A
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KR
South Korea
Prior art keywords
compound
formula
hcl
hydrochloride
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020247004672A
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English (en)
Korean (ko)
Inventor
니콜레 블루머
로맹 끌라보
파비안 파이엔
리앤 홀
스티븐 휴즈
슈테판 레버
Original Assignee
이도르시아 파마슈티컬스 리미티드
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Publication of KR20240033005A publication Critical patent/KR20240033005A/ko
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020247004672A 2021-07-13 2022-07-11 4-((r)-2-｛[6-((s)-3-메톡시-피롤리딘-1-일)-2-페닐-피리미딘-4-카르보닐]-아미노｝-3-포스포노-프로피오닐)-피페라진-1-카르복실산부틸 에스테르의 합성 방법 Pending KR20240033005A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EPPCT/EP2021/069486 2021-07-13
EP2021069486 2021-07-13
PCT/EP2022/069238 WO2023285342A2 (en) 2021-07-13 2022-07-11 A process for the synthesis of 4-((r)-2-{[6-((s)-3-methoxy-pyrrolidin-1-yl)-2-phenyl- pyrimidine-4-carbonyl]-amino}-3-phosphono-propionyl)-piperazine-1 -carboxylic acid butyl ester

Publications (1)

Publication Number Publication Date
KR20240033005A true KR20240033005A (ko) 2024-03-12

Family

ID=82748669

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020247004672A Pending KR20240033005A (ko) 2021-07-13 2022-07-11 4-((r)-2-｛[6-((s)-3-메톡시-피롤리딘-1-일)-2-페닐-피리미딘-4-카르보닐]-아미노｝-3-포스포노-프로피오닐)-피페라진-1-카르복실산부틸 에스테르의 합성 방법

Country Status (10)

Country Link
US (1) US20240317784A1 (https=)
EP (1) EP4370525A2 (https=)
JP (1) JP2024524658A (https=)
KR (1) KR20240033005A (https=)
CN (1) CN117616033A (https=)
CA (1) CA3223733A1 (https=)
IL (1) IL309948A (https=)
MX (1) MX2024000653A (https=)
TW (1) TW202317140A (https=)
WO (1) WO2023285342A2 (https=)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2225253B1 (en) * 2007-11-29 2012-06-27 Actelion Pharmaceuticals Ltd. Phosphonic acid derivates and their use as p2y12 receptor antagonists
EP3515924B1 (en) * 2016-09-22 2021-12-15 Idorsia Pharmaceuticals Ltd Crystalline forms
MA49887A (fr) 2017-03-15 2020-06-24 Idorsia Pharmaceuticals Ltd Administration sous-cutanée d'un antagoniste du récepteur p2y12

Also Published As

Publication number Publication date
JP2024524658A (ja) 2024-07-05
IL309948A (en) 2024-03-01
WO2023285342A3 (en) 2023-04-13
WO2023285342A2 (en) 2023-01-19
TW202317140A (zh) 2023-05-01
CN117616033A (zh) 2024-02-27
CA3223733A1 (en) 2023-01-19
EP4370525A2 (en) 2024-05-22
US20240317784A1 (en) 2024-09-26
MX2024000653A (es) 2024-01-31

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