CN117616033A - 4-((r)-2-{[6-((s)-3-甲氧基-吡咯烷-1-基)-2-苯基-嘧啶-4-羰基]-氨基}-3-膦酰基-丙酰基)-哌嗪-1-羧酸丁酯的合成方法 - Google Patents
4-((r)-2-{[6-((s)-3-甲氧基-吡咯烷-1-基)-2-苯基-嘧啶-4-羰基]-氨基}-3-膦酰基-丙酰基)-哌嗪-1-羧酸丁酯的合成方法 Download PDFInfo
- Publication number
- CN117616033A CN117616033A CN202280048853.5A CN202280048853A CN117616033A CN 117616033 A CN117616033 A CN 117616033A CN 202280048853 A CN202280048853 A CN 202280048853A CN 117616033 A CN117616033 A CN 117616033A
- Authority
- CN
- China
- Prior art keywords
- compound
- amount
- mixture
- hcl
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP2021/069486 | 2021-07-13 | ||
| EP2021069486 | 2021-07-13 | ||
| PCT/EP2022/069238 WO2023285342A2 (en) | 2021-07-13 | 2022-07-11 | A process for the synthesis of 4-((r)-2-{[6-((s)-3-methoxy-pyrrolidin-1-yl)-2-phenyl- pyrimidine-4-carbonyl]-amino}-3-phosphono-propionyl)-piperazine-1 -carboxylic acid butyl ester |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117616033A true CN117616033A (zh) | 2024-02-27 |
Family
ID=82748669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202280048853.5A Pending CN117616033A (zh) | 2021-07-13 | 2022-07-11 | 4-((r)-2-{[6-((s)-3-甲氧基-吡咯烷-1-基)-2-苯基-嘧啶-4-羰基]-氨基}-3-膦酰基-丙酰基)-哌嗪-1-羧酸丁酯的合成方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20240317784A1 (https=) |
| EP (1) | EP4370525A2 (https=) |
| JP (1) | JP2024524658A (https=) |
| KR (1) | KR20240033005A (https=) |
| CN (1) | CN117616033A (https=) |
| CA (1) | CA3223733A1 (https=) |
| IL (1) | IL309948A (https=) |
| MX (1) | MX2024000653A (https=) |
| TW (1) | TW202317140A (https=) |
| WO (1) | WO2023285342A2 (https=) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2225253B1 (en) * | 2007-11-29 | 2012-06-27 | Actelion Pharmaceuticals Ltd. | Phosphonic acid derivates and their use as p2y12 receptor antagonists |
| EP3515924B1 (en) * | 2016-09-22 | 2021-12-15 | Idorsia Pharmaceuticals Ltd | Crystalline forms |
| MA49887A (fr) | 2017-03-15 | 2020-06-24 | Idorsia Pharmaceuticals Ltd | Administration sous-cutanée d'un antagoniste du récepteur p2y12 |
-
2022
- 2022-07-11 MX MX2024000653A patent/MX2024000653A/es unknown
- 2022-07-11 JP JP2024501708A patent/JP2024524658A/ja active Pending
- 2022-07-11 US US18/579,110 patent/US20240317784A1/en active Pending
- 2022-07-11 KR KR1020247004672A patent/KR20240033005A/ko active Pending
- 2022-07-11 WO PCT/EP2022/069238 patent/WO2023285342A2/en not_active Ceased
- 2022-07-11 EP EP22748321.1A patent/EP4370525A2/en active Pending
- 2022-07-11 CA CA3223733A patent/CA3223733A1/en active Pending
- 2022-07-11 CN CN202280048853.5A patent/CN117616033A/zh active Pending
- 2022-07-11 IL IL309948A patent/IL309948A/en unknown
- 2022-07-12 TW TW111126010A patent/TW202317140A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2024524658A (ja) | 2024-07-05 |
| KR20240033005A (ko) | 2024-03-12 |
| IL309948A (en) | 2024-03-01 |
| WO2023285342A3 (en) | 2023-04-13 |
| WO2023285342A2 (en) | 2023-01-19 |
| TW202317140A (zh) | 2023-05-01 |
| CA3223733A1 (en) | 2023-01-19 |
| EP4370525A2 (en) | 2024-05-22 |
| US20240317784A1 (en) | 2024-09-26 |
| MX2024000653A (es) | 2024-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20250707 Address after: Singapore Exchange Applicant after: Huizhi Asia Pacific Private Ltd. Country or region after: Singapore Address before: Swiss A Skei Weil Applicant before: ACTELION PHARMACEUTICALS LTD. Country or region before: Switzerland |