JP2024522692A5 - - Google Patents

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Publication number
JP2024522692A5
JP2024522692A5 JP2023577160A JP2023577160A JP2024522692A5 JP 2024522692 A5 JP2024522692 A5 JP 2024522692A5 JP 2023577160 A JP2023577160 A JP 2023577160A JP 2023577160 A JP2023577160 A JP 2023577160A JP 2024522692 A5 JP2024522692 A5 JP 2024522692A5
Authority
JP
Japan
Prior art keywords
lipid
alkyl
pharmaceutically acceptable
acceptable salt
peg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023577160A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024522692A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2022/033334 external-priority patent/WO2022266032A1/en
Publication of JP2024522692A publication Critical patent/JP2024522692A/ja
Publication of JP2024522692A5 publication Critical patent/JP2024522692A5/ja
Pending legal-status Critical Current

Links

JP2023577160A 2021-06-14 2022-06-14 カチオン性脂質及びその組成物 Pending JP2024522692A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163210204P 2021-06-14 2021-06-14
US63/210,204 2021-06-14
PCT/US2022/033334 WO2022266032A1 (en) 2021-06-14 2022-06-14 Cationic lipids and compositions thereof

Publications (2)

Publication Number Publication Date
JP2024522692A JP2024522692A (ja) 2024-06-21
JP2024522692A5 true JP2024522692A5 (enExample) 2025-06-24

Family

ID=82547431

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023577160A Pending JP2024522692A (ja) 2021-06-14 2022-06-14 カチオン性脂質及びその組成物

Country Status (10)

Country Link
US (1) US20240293574A1 (enExample)
EP (1) EP4355727A1 (enExample)
JP (1) JP2024522692A (enExample)
KR (1) KR20240023420A (enExample)
CN (1) CN117642380A (enExample)
AU (1) AU2022291742A1 (enExample)
CA (1) CA3222589A1 (enExample)
IL (1) IL309145A (enExample)
MX (1) MX2023014855A (enExample)
WO (1) WO2022266032A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116082184B (zh) * 2023-04-12 2023-06-30 山东大学 基于环己二胺的可电离脂质、脂质纳米颗粒及其制备方法与应用
AU2024279278A1 (en) 2023-05-31 2025-12-18 Capstan Therapeutics, Inc. Lipid nanoparticle formulations and compositions
KR102898792B1 (ko) * 2023-06-26 2025-12-19 주식회사 무진메디 이온화 가능한 펩타이드를 이용한 지질 나노입자 기반 약물 전달체 및 이의 제조방법
WO2025005632A1 (ko) * 2023-06-26 2025-01-02 주식회사 무진메디 이온화 가능한 펩타이드를 이용한 지질 나노입자 기반 약물 전달체 및 이의 제조방법
WO2025143892A1 (ko) * 2023-12-29 2025-07-03 주식회사 삼양홀딩스 약물전달용 나노입자의 조성물
CN117964577B (zh) * 2024-03-29 2024-06-21 天津全和诚生物技术有限公司 阳离子脂质化合物、其制备方法、包含其的组合物及应用
WO2026003582A2 (en) 2024-06-27 2026-01-02 Axelyf ehf. Lipids and lipid nanoparticles
CN118634207B (zh) * 2024-08-15 2024-11-26 北京悦康科创医药科技股份有限公司 一种雾化吸入用核酸-脂质纳米粒及其制备方法和应用
CN118903476B (zh) * 2024-10-10 2025-05-06 嘉晨西海(南昌)生物制药有限公司 含LNP和mRNA的组合物及其在治疗戈谢病中的应用

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5885613A (en) 1994-09-30 1999-03-23 The University Of British Columbia Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
US5928906A (en) 1996-05-09 1999-07-27 Sequenom, Inc. Process for direct sequencing during template amplification
AU733310C (en) 1997-05-14 2001-11-29 University Of British Columbia, The High efficiency encapsulation of charged therapeutic agents in lipid vesicles
US7201898B2 (en) 2000-06-01 2007-04-10 The University Of North Carolina At Chapel Hill Methods and compounds for controlled release of recombinant parvovirus vectors
WO2002087541A1 (en) 2001-04-30 2002-11-07 Protiva Biotherapeutics Inc. Lipid-based formulations for gene transfer
EP1519714B1 (en) 2002-06-28 2010-10-20 Protiva Biotherapeutics Inc. Method and apparatus for producing liposomes
EP1664316B1 (en) 2003-09-15 2012-08-29 Protiva Biotherapeutics Inc. Polyethyleneglycol-modified lipid compounds and uses thereof
US7404969B2 (en) 2005-02-14 2008-07-29 Sirna Therapeutics, Inc. Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules
CN101267805A (zh) 2005-07-27 2008-09-17 普洛体维生物治疗公司 制造脂质体的系统和方法
CA2689042A1 (en) 2007-02-16 2008-08-28 Merck & Co., Inc. Compositions and methods for potentiated activity of biologicaly active molecules
WO2009086558A1 (en) 2008-01-02 2009-07-09 Tekmira Pharmaceuticals Corporation Improved compositions and methods for the delivery of nucleic acids
CA2721333C (en) 2008-04-15 2020-12-01 Protiva Biotherapeutics, Inc. Novel lipid formulations for nucleic acid delivery
US20130037977A1 (en) 2010-04-08 2013-02-14 Paul A. Burke Preparation of Lipid Nanoparticles
US20130156845A1 (en) 2010-04-29 2013-06-20 Alnylam Pharmaceuticals, Inc. Lipid formulated single stranded rna
WO2012024526A2 (en) 2010-08-20 2012-02-23 Cerulean Pharma Inc. Conjugates, particles, compositions, and related methods
EP3485875A1 (en) 2011-11-04 2019-05-22 Nitto Denko Corporation Single use system for sterelily producing lipid-nucleic acid particles
TW201808342A (zh) 2012-05-02 2018-03-16 喜納製藥公司 包含四galnac之新穎結合物及傳送寡核苷酸之方法
CN105085292B (zh) * 2014-05-23 2017-12-15 上海交通大学 3‑((2‑(二甲氨基)乙烷基)(甲基)氨基)丙酸的两亲性衍生物及其用途
PT3313829T (pt) 2015-06-29 2024-07-08 Acuitas Therapeutics Inc Formulações de lípidos e de nanopartículas lipídicas para a administração de ácidos nucleicos
JP6948313B6 (ja) 2015-09-17 2022-01-14 モデルナティエックス インコーポレイテッド 治療剤の細胞内送達のための化合物および組成物
HRP20230209T1 (hr) 2015-10-28 2023-04-14 Acuitas Therapeutics Inc. Novi lipidi i lipidne formulacije nanočestica za isporuku nukleinskih kiselina
BR112018003910B1 (pt) 2015-11-16 2022-03-22 F. Hoffmann-La Roche Ag Derivado de fosforamidita galnac, processo para a preparação de um derivado de fosforamidita galnac de fórmula i e uso dos derivados de fosforamidita galnac de fórmula i
PL3386484T3 (pl) 2015-12-10 2022-07-25 Modernatx, Inc. Kompozycje i sposoby dostarczania środków terapeutycznych
JP7194594B2 (ja) * 2016-05-18 2022-12-22 モデルナティエックス インコーポレイテッド 免疫調節ポリペプチドをコードするmRNAの組み合わせ及びその使用
MA45036A (fr) * 2016-05-18 2019-03-27 Modernatx Inc Polynucléotides codant pour la citrine pour le traitement de la citrullinémie de type 2
EP4186888B1 (en) * 2017-03-15 2025-11-26 ModernaTX, Inc. Compound and compositions for intracellular delivery of therapeutic agents
JP7630904B2 (ja) * 2019-07-23 2025-02-18 株式会社東芝 核酸導入キャリア、核酸導入キャリアセット、核酸導入組成物及び核酸導入方法
WO2021046265A1 (en) * 2019-09-06 2021-03-11 Generation Bio Co. Lipid nanoparticle compositions comprising closed-ended dna and cleavable lipids and methods of use thereof
WO2021092194A1 (en) * 2019-11-05 2021-05-14 Vicarious Surgical Inc. Surgical virtual reality user interface
JP2023502576A (ja) * 2019-11-22 2023-01-25 ジェネレーション バイオ カンパニー イオン化可能な脂質およびそれらのナノ粒子組成物
KR20230034333A (ko) * 2020-07-02 2023-03-09 라이프 테크놀로지스 코포레이션 트리뉴클레오티드 캡 유사체, 제조 및 이의 용도
AU2021307952A1 (en) * 2020-07-17 2023-03-02 Generation Bio Co. Methods for encapsulating polynucleotides into reduced sizes of Lipid nanoparticles and novel formulation thereof

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