JP2023518985A5 - - Google Patents
Info
- Publication number
- JP2023518985A5 JP2023518985A5 JP2022558110A JP2022558110A JP2023518985A5 JP 2023518985 A5 JP2023518985 A5 JP 2023518985A5 JP 2022558110 A JP2022558110 A JP 2022558110A JP 2022558110 A JP2022558110 A JP 2022558110A JP 2023518985 A5 JP2023518985 A5 JP 2023518985A5
- Authority
- JP
- Japan
- Prior art keywords
- lipid
- item
- pharmaceutically acceptable
- alkyl
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025154013A JP2025181861A (ja) | 2020-03-27 | 2025-09-17 | 新規脂質及びそれらのナノ粒子組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063000990P | 2020-03-27 | 2020-03-27 | |
| US63/000,990 | 2020-03-27 | ||
| PCT/US2021/024413 WO2021195529A2 (en) | 2020-03-27 | 2021-03-26 | Novel lipids and nanoparticle compositions thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025154013A Division JP2025181861A (ja) | 2020-03-27 | 2025-09-17 | 新規脂質及びそれらのナノ粒子組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023518985A JP2023518985A (ja) | 2023-05-09 |
| JP2023518985A5 true JP2023518985A5 (enExample) | 2024-04-04 |
| JP7746280B2 JP7746280B2 (ja) | 2025-09-30 |
Family
ID=77890624
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022558110A Active JP7746280B2 (ja) | 2020-03-27 | 2021-03-26 | 新規脂質及びそれらのナノ粒子組成物 |
| JP2025154013A Pending JP2025181861A (ja) | 2020-03-27 | 2025-09-17 | 新規脂質及びそれらのナノ粒子組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025154013A Pending JP2025181861A (ja) | 2020-03-27 | 2025-09-17 | 新規脂質及びそれらのナノ粒子組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US12534435B2 (enExample) |
| EP (1) | EP4125821A4 (enExample) |
| JP (2) | JP7746280B2 (enExample) |
| KR (1) | KR20220160647A (enExample) |
| CN (1) | CN115916163A (enExample) |
| AU (1) | AU2021241696A1 (enExample) |
| BR (1) | BR112022019369A2 (enExample) |
| CA (1) | CA3173126A1 (enExample) |
| IL (1) | IL296763B2 (enExample) |
| MX (1) | MX2022011988A (enExample) |
| WO (1) | WO2021195529A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20240586T1 (hr) | 2018-10-09 | 2024-07-19 | The University Of British Columbia | Sastavi i sustavi koji sadrže transfekcijske sposobne vezikle bez organskih otapala i deterdženta i s njim povezanim postupcima |
| JP7746280B2 (ja) | 2020-03-27 | 2025-09-30 | ジェネレーション バイオ カンパニー | 新規脂質及びそれらのナノ粒子組成物 |
| AU2021307952A1 (en) * | 2020-07-17 | 2023-03-02 | Generation Bio Co. | Methods for encapsulating polynucleotides into reduced sizes of Lipid nanoparticles and novel formulation thereof |
| WO2022115645A1 (en) | 2020-11-25 | 2022-06-02 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of nucleic acids, and related methods of use |
| CA3234321A1 (en) * | 2021-09-30 | 2023-04-06 | Nof Corporation | Lipid nanoparticles used to transport nucleic acids into lymphatic endothelium cells |
| EP4452942A1 (en) * | 2021-12-20 | 2024-10-30 | Beam Therapeutics Inc. | Nanomaterials comprising disulfides |
| WO2023190175A1 (ja) | 2022-03-28 | 2023-10-05 | 日油株式会社 | 末梢血単核細胞へ核酸を送達するための脂質ナノ粒子およびこれを用いて末梢血単核細胞へ核酸を送達する方法 |
| US20260115316A1 (en) | 2022-03-28 | 2026-04-30 | Nof Corporation | Lipid nanoparticles for delivering nucleic acid to splenic tissue, and method for delivering nucleic acid to splenic tissue using same |
| JPWO2023190164A1 (enExample) * | 2022-03-28 | 2023-10-05 | ||
| WO2023190170A1 (ja) | 2022-03-28 | 2023-10-05 | 日油株式会社 | 核酸内封脂質ナノ粒子の製造方法及びこれを含む医薬品組成物の製造方法、並びに、核酸を細胞内又は標的細胞内に導入する方法 |
| CA3256897A1 (en) | 2022-05-25 | 2023-11-30 | Akagera Medicines, Inc. | Lipid nanoparticles for the administration of nucleic acids and their methods of use |
| CN119604276A (zh) | 2022-07-15 | 2025-03-11 | 日油株式会社 | 脂质纳米粒子及其制造方法、封入有核酸的脂质纳米粒子及其制造方法以及使用封入有核酸的脂质纳米粒子赋予生物体获得性免疫的方法 |
| CA3262131A1 (en) | 2022-07-15 | 2025-06-13 | Nof Corporation | FREEZE-DRIED COMPOSITION OF LIPID NANOPARTICLES CHARGED WITH NUCLEIC ACID |
| EP4683905A1 (en) * | 2023-03-22 | 2026-01-28 | Nanovation Therapeutics Inc. | Ionizable anionic lipids |
| CN120957730A (zh) | 2023-03-29 | 2025-11-14 | 国立大学法人东北大学 | 核酸封装脂质纳米粒子的制造方法 |
| CN116082184B (zh) * | 2023-04-12 | 2023-06-30 | 山东大学 | 基于环己二胺的可电离脂质、脂质纳米颗粒及其制备方法与应用 |
| AU2024279278A1 (en) | 2023-05-31 | 2025-12-18 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| WO2025043146A2 (en) * | 2023-08-24 | 2025-02-27 | Molecular Axiom Inc. | Lipid nanoparticle compositions and methods of using same |
| CN121263400A (zh) * | 2023-12-15 | 2026-01-02 | 厦门赛诺邦格生物科技股份有限公司 | 一种含二硫键的可降解阳离子脂质及其应用 |
| CN117964577B (zh) * | 2024-03-29 | 2024-06-21 | 天津全和诚生物技术有限公司 | 阳离子脂质化合物、其制备方法、包含其的组合物及应用 |
| WO2026003582A2 (en) | 2024-06-27 | 2026-01-02 | Axelyf ehf. | Lipids and lipid nanoparticles |
| WO2026070952A1 (ja) * | 2024-09-27 | 2026-04-02 | 日油株式会社 | ジスルフィド結合を有する化合物およびその製造方法 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US5885613A (en) | 1994-09-30 | 1999-03-23 | The University Of British Columbia | Bilayer stabilizing components and their use in forming programmable fusogenic liposomes |
| US5928906A (en) | 1996-05-09 | 1999-07-27 | Sequenom, Inc. | Process for direct sequencing during template amplification |
| AU733310C (en) | 1997-05-14 | 2001-11-29 | University Of British Columbia, The | High efficiency encapsulation of charged therapeutic agents in lipid vesicles |
| US6320017B1 (en) | 1997-12-23 | 2001-11-20 | Inex Pharmaceuticals Corp. | Polyamide oligomers |
| US7201898B2 (en) | 2000-06-01 | 2007-04-10 | The University Of North Carolina At Chapel Hill | Methods and compounds for controlled release of recombinant parvovirus vectors |
| WO2002087541A1 (en) | 2001-04-30 | 2002-11-07 | Protiva Biotherapeutics Inc. | Lipid-based formulations for gene transfer |
| EP1519714B1 (en) | 2002-06-28 | 2010-10-20 | Protiva Biotherapeutics Inc. | Method and apparatus for producing liposomes |
| EP1664316B1 (en) | 2003-09-15 | 2012-08-29 | Protiva Biotherapeutics Inc. | Polyethyleneglycol-modified lipid compounds and uses thereof |
| US7404969B2 (en) | 2005-02-14 | 2008-07-29 | Sirna Therapeutics, Inc. | Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules |
| CN101267805A (zh) | 2005-07-27 | 2008-09-17 | 普洛体维生物治疗公司 | 制造脂质体的系统和方法 |
| CA2689042A1 (en) | 2007-02-16 | 2008-08-28 | Merck & Co., Inc. | Compositions and methods for potentiated activity of biologicaly active molecules |
| WO2009086558A1 (en) | 2008-01-02 | 2009-07-09 | Tekmira Pharmaceuticals Corporation | Improved compositions and methods for the delivery of nucleic acids |
| CA2721333C (en) | 2008-04-15 | 2020-12-01 | Protiva Biotherapeutics, Inc. | Novel lipid formulations for nucleic acid delivery |
| US8883211B2 (en) | 2008-07-10 | 2014-11-11 | Serina Therapeutics, Inc. | Polyoxazolines with inert terminating groups, polyoxazolines prepared from protected initiating groups and related compounds |
| US20130037977A1 (en) | 2010-04-08 | 2013-02-14 | Paul A. Burke | Preparation of Lipid Nanoparticles |
| US20130156845A1 (en) | 2010-04-29 | 2013-06-20 | Alnylam Pharmaceuticals, Inc. | Lipid formulated single stranded rna |
| US9006417B2 (en) | 2010-06-30 | 2015-04-14 | Protiva Biotherapeutics, Inc. | Non-liposomal systems for nucleic acid delivery |
| WO2012024526A2 (en) | 2010-08-20 | 2012-02-23 | Cerulean Pharma Inc. | Conjugates, particles, compositions, and related methods |
| WO2012046265A1 (ja) * | 2010-10-05 | 2012-04-12 | トヨタ自動車株式会社 | 推定装置および推定方法 |
| EP2500434A1 (en) | 2011-03-12 | 2012-09-19 | Association Institut de Myologie | Capsid-free AAV vectors, compositions, and methods for vector production and gene delivery |
| EP3485875A1 (en) | 2011-11-04 | 2019-05-22 | Nitto Denko Corporation | Single use system for sterelily producing lipid-nucleic acid particles |
| WO2013073480A1 (ja) | 2011-11-18 | 2013-05-23 | 日油株式会社 | 細胞内動態を改善したカチオン性脂質 |
| TW201808342A (zh) | 2012-05-02 | 2018-03-16 | 喜納製藥公司 | 包含四ｇａｌｎａｃ之新穎結合物及傳送寡核苷酸之方法 |
| US10426737B2 (en) | 2013-12-19 | 2019-10-01 | Novartis Ag | Lipids and lipid compositions for the delivery of active agents |
| HUE060907T2 (hu) | 2014-06-25 | 2023-04-28 | Acuitas Therapeutics Inc | Új lipidek és lipid nanorészecske formulációk nukleinsavak bevitelére |
| PT3313829T (pt) | 2015-06-29 | 2024-07-08 | Acuitas Therapeutics Inc | Formulações de lípidos e de nanopartículas lipídicas para a administração de ácidos nucleicos |
| HRP20230209T1 (hr) | 2015-10-28 | 2023-04-14 | Acuitas Therapeutics Inc. | Novi lipidi i lipidne formulacije nanočestica za isporuku nukleinskih kiselina |
| BR112018003910B1 (pt) | 2015-11-16 | 2022-03-22 | F. Hoffmann-La Roche Ag | Derivado de fosforamidita galnac, processo para a preparação de um derivado de fosforamidita galnac de fórmula i e uso dos derivados de fosforamidita galnac de fórmula i |
| PL3386484T3 (pl) | 2015-12-10 | 2022-07-25 | Modernatx, Inc. | Kompozycje i sposoby dostarczania środków terapeutycznych |
| WO2017117528A1 (en) | 2015-12-30 | 2017-07-06 | Acuitas Therapeutics, Inc. | Lipids and lipid nanoparticle formulations for delivery of nucleic acids |
| MX2018010633A (es) | 2016-03-03 | 2019-06-13 | Univ Massachusetts | Acido desoxirribonucleico (adn) lineal duplex de extremos cerrados para transferencia genica no viral. |
| CN111902397B (zh) | 2018-03-27 | 2024-04-12 | 日油株式会社 | 改进了细胞内动力学的阳离子脂质 |
| JP7075256B2 (ja) * | 2018-03-28 | 2022-05-25 | 三菱重工業株式会社 | 配管の余寿命評価方法 |
| WO2021046265A1 (en) | 2019-09-06 | 2021-03-11 | Generation Bio Co. | Lipid nanoparticle compositions comprising closed-ended dna and cleavable lipids and methods of use thereof |
| JP7746280B2 (ja) * | 2020-03-27 | 2025-09-30 | ジェネレーション バイオ カンパニー | 新規脂質及びそれらのナノ粒子組成物 |
| AU2021307952A1 (en) * | 2020-07-17 | 2023-03-02 | Generation Bio Co. | Methods for encapsulating polynucleotides into reduced sizes of Lipid nanoparticles and novel formulation thereof |
-
2021
- 2021-03-26 JP JP2022558110A patent/JP7746280B2/ja active Active
- 2021-03-26 CA CA3173126A patent/CA3173126A1/en active Pending
- 2021-03-26 IL IL296763A patent/IL296763B2/en unknown
- 2021-03-26 BR BR112022019369A patent/BR112022019369A2/pt unknown
- 2021-03-26 CN CN202180037847.5A patent/CN115916163A/zh active Pending
- 2021-03-26 MX MX2022011988A patent/MX2022011988A/es unknown
- 2021-03-26 WO PCT/US2021/024413 patent/WO2021195529A2/en not_active Ceased
- 2021-03-26 KR KR1020227037604A patent/KR20220160647A/ko active Pending
- 2021-03-26 EP EP21776608.8A patent/EP4125821A4/en active Pending
- 2021-03-26 US US17/913,498 patent/US12534435B2/en active Active
- 2021-03-26 AU AU2021241696A patent/AU2021241696A1/en active Pending
-
2024
- 2024-04-24 US US18/644,728 patent/US12252470B2/en active Active
-
2025
- 2025-01-31 US US19/042,351 patent/US20250361208A1/en active Pending
- 2025-09-17 JP JP2025154013A patent/JP2025181861A/ja active Pending
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