JP2022546597A5 - - Google Patents
Info
- Publication number
- JP2022546597A5 JP2022546597A5 JP2022514708A JP2022514708A JP2022546597A5 JP 2022546597 A5 JP2022546597 A5 JP 2022546597A5 JP 2022514708 A JP2022514708 A JP 2022514708A JP 2022514708 A JP2022514708 A JP 2022514708A JP 2022546597 A5 JP2022546597 A5 JP 2022546597A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- item
- itr
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962896980P | 2019-09-06 | 2019-09-06 | |
| US62/896,980 | 2019-09-06 | ||
| US201962910720P | 2019-10-04 | 2019-10-04 | |
| US62/910,720 | 2019-10-04 | ||
| US201962940104P | 2019-11-25 | 2019-11-25 | |
| US62/940,104 | 2019-11-25 | ||
| PCT/US2020/049266 WO2021046265A1 (en) | 2019-09-06 | 2020-09-03 | Lipid nanoparticle compositions comprising closed-ended dna and cleavable lipids and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022546597A JP2022546597A (ja) | 2022-11-04 |
| JP2022546597A5 true JP2022546597A5 (enExample) | 2023-09-11 |
| JP7700101B2 JP7700101B2 (ja) | 2025-06-30 |
Family
ID=74853052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022514708A Active JP7700101B2 (ja) | 2019-09-06 | 2020-09-03 | 閉端ｄｎａおよび切断可能脂質を含む脂質ナノ粒子組成物ならびにそれらの使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20220280427A1 (enExample) |
| EP (1) | EP4025196A4 (enExample) |
| JP (1) | JP7700101B2 (enExample) |
| CN (1) | CN114929205B (enExample) |
| AU (1) | AU2020342668B2 (enExample) |
| CA (1) | CA3150452A1 (enExample) |
| IL (1) | IL291038A (enExample) |
| WO (1) | WO2021046265A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4035686A4 (en) * | 2019-09-26 | 2023-11-01 | NOF Corporation | FREEZE DRIED COMPOSITION OF LIPID NANOPARTICLES |
| JP7746280B2 (ja) | 2020-03-27 | 2025-09-30 | ジェネレーション バイオ カンパニー | 新規脂質及びそれらのナノ粒子組成物 |
| IL298241A (en) * | 2020-05-18 | 2023-01-01 | Generation Bio Co | New lipids and their nanoparticle preparations |
| AU2021307952A1 (en) * | 2020-07-17 | 2023-03-02 | Generation Bio Co. | Methods for encapsulating polynucleotides into reduced sizes of Lipid nanoparticles and novel formulation thereof |
| JP2023535632A (ja) | 2020-07-27 | 2023-08-18 | アンジャリウム バイオサイエンシズ エージー | Ｄｎａ分子の組成物、その作製方法、及びその使用方法 |
| CZ310613B6 (cs) | 2020-09-23 | 2026-01-28 | Ústav organické chemie a biochemie AV ČR, v. v. i. | Lipidoidy pro transfekci nukleových kyselin a jejich použití |
| WO2022115645A1 (en) | 2020-11-25 | 2022-06-02 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of nucleic acids, and related methods of use |
| CA3221454A1 (en) * | 2021-06-07 | 2022-12-15 | Michelle LEBLANC | Apoe and apob modified lipid nanoparticle compositions and uses thereof |
| AU2022291742A1 (en) * | 2021-06-14 | 2023-12-21 | Generation Bio Co. | Cationic lipids and compositions thereof |
| KR20240038705A (ko) * | 2021-06-22 | 2024-03-25 | 인텔리아 테라퓨틱스, 인크. | 간 유전자의 생체 내 편집 방법 |
| CZ310443B6 (cs) | 2021-07-19 | 2025-06-25 | Ústav organické chemie a biochemie AV ČR, v. v. i. | Cyklohexanové lipidoidy pro transfekci nukleových kyselin a jejich použití |
| US12251471B2 (en) * | 2021-07-26 | 2025-03-18 | Oregon State University | Inhalable therapeutics |
| CA3234321A1 (en) * | 2021-09-30 | 2023-04-06 | Nof Corporation | Lipid nanoparticles used to transport nucleic acids into lymphatic endothelium cells |
| CN114432502B (zh) * | 2021-12-31 | 2023-02-03 | 中山大学附属第八医院（深圳福田） | 一种负载op3-4多肽、抗cxcl9抗体的水凝胶及其制备方法与应用 |
| US20260115316A1 (en) * | 2022-03-28 | 2026-04-30 | Nof Corporation | Lipid nanoparticles for delivering nucleic acid to splenic tissue, and method for delivering nucleic acid to splenic tissue using same |
| WO2023190175A1 (ja) * | 2022-03-28 | 2023-10-05 | 日油株式会社 | 末梢血単核細胞へ核酸を送達するための脂質ナノ粒子およびこれを用いて末梢血単核細胞へ核酸を送達する方法 |
| CA3256897A1 (en) | 2022-05-25 | 2023-11-30 | Akagera Medicines, Inc. | Lipid nanoparticles for the administration of nucleic acids and their methods of use |
| WO2024112943A1 (en) * | 2022-11-22 | 2024-05-30 | University Of Maryland, Baltimore | Activated nanotherapy for sickle cell disease |
| WO2024140893A1 (zh) | 2022-12-29 | 2024-07-04 | 辽宁键凯科技有限公司 | 一种类固醇-阳离子脂质化合物及其应用 |
| AU2024279278A1 (en) | 2023-05-31 | 2025-12-18 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| WO2025188836A1 (en) * | 2024-03-05 | 2025-09-12 | Saliogen Therapeutics, Inc. | Compositions and methods of using gene coding for treating ocular disease |
| WO2025213135A1 (en) * | 2024-04-04 | 2025-10-09 | The Brigham And Women's Hospital, Inc. | Lipid nanoparticles for the treatment of vascular diseases |
| WO2026003582A2 (en) | 2024-06-27 | 2026-01-02 | Axelyf ehf. | Lipids and lipid nanoparticles |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US5885613A (en) | 1994-09-30 | 1999-03-23 | The University Of British Columbia | Bilayer stabilizing components and their use in forming programmable fusogenic liposomes |
| US5928906A (en) | 1996-05-09 | 1999-07-27 | Sequenom, Inc. | Process for direct sequencing during template amplification |
| AU733310C (en) | 1997-05-14 | 2001-11-29 | University Of British Columbia, The | High efficiency encapsulation of charged therapeutic agents in lipid vesicles |
| US6320017B1 (en) | 1997-12-23 | 2001-11-20 | Inex Pharmaceuticals Corp. | Polyamide oligomers |
| US7201898B2 (en) | 2000-06-01 | 2007-04-10 | The University Of North Carolina At Chapel Hill | Methods and compounds for controlled release of recombinant parvovirus vectors |
| WO2002087541A1 (en) | 2001-04-30 | 2002-11-07 | Protiva Biotherapeutics Inc. | Lipid-based formulations for gene transfer |
| EP1519714B1 (en) | 2002-06-28 | 2010-10-20 | Protiva Biotherapeutics Inc. | Method and apparatus for producing liposomes |
| WO2004078941A2 (en) | 2003-03-06 | 2004-09-16 | Oligo Engine, Inc. | Modulation of gene expression using dna-rna hybrids |
| US20050148531A1 (en) | 2003-05-15 | 2005-07-07 | Todd Hauser | Modulation of gene expression using DNA-DNA hybrids |
| EP1664316B1 (en) | 2003-09-15 | 2012-08-29 | Protiva Biotherapeutics Inc. | Polyethyleneglycol-modified lipid compounds and uses thereof |
| US7404969B2 (en) | 2005-02-14 | 2008-07-29 | Sirna Therapeutics, Inc. | Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules |
| CN101267805A (zh) | 2005-07-27 | 2008-09-17 | 普洛体维生物治疗公司 | 制造脂质体的系统和方法 |
| CA2927045A1 (en) | 2006-10-03 | 2008-04-10 | Muthiah Manoharan | Lipid containing formulations |
| CA2689042A1 (en) | 2007-02-16 | 2008-08-28 | Merck & Co., Inc. | Compositions and methods for potentiated activity of biologicaly active molecules |
| WO2009086558A1 (en) | 2008-01-02 | 2009-07-09 | Tekmira Pharmaceuticals Corporation | Improved compositions and methods for the delivery of nucleic acids |
| CA2721333C (en) | 2008-04-15 | 2020-12-01 | Protiva Biotherapeutics, Inc. | Novel lipid formulations for nucleic acid delivery |
| US8883211B2 (en) | 2008-07-10 | 2014-11-11 | Serina Therapeutics, Inc. | Polyoxazolines with inert terminating groups, polyoxazolines prepared from protected initiating groups and related compounds |
| KR101766408B1 (ko) | 2009-06-10 | 2017-08-10 | 알닐람 파마슈티칼스 인코포레이티드 | 향상된 지질 조성물 |
| US20130037977A1 (en) | 2010-04-08 | 2013-02-14 | Paul A. Burke | Preparation of Lipid Nanoparticles |
| US20130156845A1 (en) | 2010-04-29 | 2013-06-20 | Alnylam Pharmaceuticals, Inc. | Lipid formulated single stranded rna |
| US9006417B2 (en) | 2010-06-30 | 2015-04-14 | Protiva Biotherapeutics, Inc. | Non-liposomal systems for nucleic acid delivery |
| WO2012024526A2 (en) | 2010-08-20 | 2012-02-23 | Cerulean Pharma Inc. | Conjugates, particles, compositions, and related methods |
| CA2809858C (en) | 2010-09-20 | 2019-11-12 | Sirna Therapeutics, Inc. | Novel low molecular weight cationic lipids for oligonucleotide delivery |
| EP2500434A1 (en) * | 2011-03-12 | 2012-09-19 | Association Institut de Myologie | Capsid-free AAV vectors, compositions, and methods for vector production and gene delivery |
| ES2795110T3 (es) | 2011-06-08 | 2020-11-20 | Translate Bio Inc | Lípidos escindibles |
| EP3485875A1 (en) | 2011-11-04 | 2019-05-22 | Nitto Denko Corporation | Single use system for sterelily producing lipid-nucleic acid particles |
| WO2013073480A1 (ja) | 2011-11-18 | 2013-05-23 | 日油株式会社 | 細胞内動態を改善したカチオン性脂質 |
| AU2013237874B2 (en) * | 2012-03-29 | 2018-01-18 | Translate Bio, Inc. | Lipid-derived neutral nanoparticles |
| AU2014348212C1 (en) | 2013-11-18 | 2018-11-29 | Arcturus Therapeutics, Inc. | Ionizable cationic lipid for RNA delivery |
| US10426737B2 (en) | 2013-12-19 | 2019-10-01 | Novartis Ag | Lipids and lipid compositions for the delivery of active agents |
| HUE060907T2 (hu) | 2014-06-25 | 2023-04-28 | Acuitas Therapeutics Inc | Új lipidek és lipid nanorészecske formulációk nukleinsavak bevitelére |
| WO2016079197A1 (en) * | 2014-11-18 | 2016-05-26 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Delivery enhancers for conjugated sirna and lipid nanoparticles |
| CA2975371C (en) * | 2015-01-30 | 2024-02-13 | Nof Corporation | Cationic lipid for nucleic acid delivery |
| PT3313829T (pt) | 2015-06-29 | 2024-07-08 | Acuitas Therapeutics Inc | Formulações de lípidos e de nanopartículas lipídicas para a administração de ácidos nucleicos |
| HRP20230209T1 (hr) | 2015-10-28 | 2023-04-14 | Acuitas Therapeutics Inc. | Novi lipidi i lipidne formulacije nanočestica za isporuku nukleinskih kiselina |
| PL3386484T3 (pl) | 2015-12-10 | 2022-07-25 | Modernatx, Inc. | Kompozycje i sposoby dostarczania środków terapeutycznych |
| WO2017117528A1 (en) | 2015-12-30 | 2017-07-06 | Acuitas Therapeutics, Inc. | Lipids and lipid nanoparticle formulations for delivery of nucleic acids |
| EP3315125A1 (en) * | 2016-10-31 | 2018-05-02 | Silence Therapeutics (London) Ltd | Lipid nanoparticle formulation |
| WO2018237369A2 (en) * | 2017-06-23 | 2018-12-27 | Vical Incorporated | Lipid nanoparticle (lnp)-mediated delivery of a crispr-expressing plasmid dna for treating chronic hepatitis b virus infection |
| CA3075168A1 (en) * | 2017-09-08 | 2019-03-14 | Generation Bio Co. | Modified closed-ended dna (cedna) |
| KR102696307B1 (ko) * | 2017-09-08 | 2024-08-16 | 제너레이션 바이오 컴퍼니 | 비-바이러스성 캡시드-비함유 dna 벡터의 지질 나노입자 제형 |
| KR20200120649A (ko) * | 2018-02-14 | 2020-10-21 | 제너레이션 바이오 컴퍼니 | 비-바이러스 dna 벡터 및 항체 및 융합 단백질 생산을 위한 이의 용도 |
| CN111902397B (zh) * | 2018-03-27 | 2024-04-12 | 日油株式会社 | 改进了细胞内动力学的阳离子脂质 |
-
2020
- 2020-09-03 WO PCT/US2020/049266 patent/WO2021046265A1/en not_active Ceased
- 2020-09-03 JP JP2022514708A patent/JP7700101B2/ja active Active
- 2020-09-03 CN CN202080076963.3A patent/CN114929205B/zh active Active
- 2020-09-03 AU AU2020342668A patent/AU2020342668B2/en active Active
- 2020-09-03 CA CA3150452A patent/CA3150452A1/en active Pending
- 2020-09-03 US US17/632,262 patent/US20220280427A1/en active Pending
- 2020-09-03 EP EP20860233.4A patent/EP4025196A4/en active Pending
-
2022
- 2022-03-01 IL IL291038A patent/IL291038A/en unknown
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