JP2024521878A5 - - Google Patents
Info
- Publication number
- JP2024521878A5 JP2024521878A5 JP2023574119A JP2023574119A JP2024521878A5 JP 2024521878 A5 JP2024521878 A5 JP 2024521878A5 JP 2023574119 A JP2023574119 A JP 2023574119A JP 2023574119 A JP2023574119 A JP 2023574119A JP 2024521878 A5 JP2024521878 A5 JP 2024521878A5
- Authority
- JP
- Japan
- Prior art keywords
- halo
- alkyl
- pharmaceutically acceptable
- acceptable salt
- diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163196339P | 2021-06-03 | 2021-06-03 | |
| US63/196,339 | 2021-06-03 | ||
| US202163290019P | 2021-12-15 | 2021-12-15 | |
| US63/290,019 | 2021-12-15 | ||
| US202263346120P | 2022-05-26 | 2022-05-26 | |
| US63/346,120 | 2022-05-26 | ||
| PCT/US2022/032042 WO2022256586A2 (en) | 2021-06-03 | 2022-06-03 | Substituted indole compounds and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024521878A JP2024521878A (ja) | 2024-06-04 |
| JP2024521878A5 true JP2024521878A5 (enExample) | 2025-06-02 |
| JP7895996B2 JP7895996B2 (ja) | 2026-07-28 |
Family
ID=84323595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023574119A Active JP7895996B2 (ja) | 2021-06-03 | 2022-06-03 | 置換インドール化合物及びその使用方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20240287034A1 (enExample) |
| EP (1) | EP4346812A4 (enExample) |
| JP (1) | JP7895996B2 (enExample) |
| KR (1) | KR20240017004A (enExample) |
| CN (1) | CN120081822A (enExample) |
| AU (1) | AU2022283903A1 (enExample) |
| BR (1) | BR112023025235A2 (enExample) |
| CA (1) | CA3222144A1 (enExample) |
| CL (1) | CL2023003591A1 (enExample) |
| CO (1) | CO2023016557A2 (enExample) |
| CR (1) | CR20230564A (enExample) |
| DO (1) | DOP2023000263A (enExample) |
| EC (1) | ECSP23090260A (enExample) |
| IL (1) | IL308835A (enExample) |
| JO (1) | JOP20230315A1 (enExample) |
| MX (1) | MX2023014274A (enExample) |
| PE (1) | PE20250114A1 (enExample) |
| PH (1) | PH12023553130A1 (enExample) |
| WO (1) | WO2022256586A2 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20230049115A (ko) * | 2020-08-07 | 2023-04-12 | 상하이 메이유에 바이오테크 디벨롭먼트 컴퍼니 리미티드 | 보체 인자 b 억제제 및 이의 약학적 조성물, 제조 방법 및 용도 |
| US20240109861A1 (en) * | 2020-12-30 | 2024-04-04 | Medshine Discovery Inc. | Series of piperidine-substituted benzoic acid compounds, and use thereof |
| WO2023278698A1 (en) * | 2021-06-30 | 2023-01-05 | Apellis Pharmaceuticals, Inc. | Complement inhibition |
| CN118043314A (zh) | 2021-08-18 | 2024-05-14 | 西藏海思科制药有限公司 | 一种苯并氮杂芳环衍生物及其在医药上的应用 |
| AU2022376760A1 (en) * | 2021-10-27 | 2024-05-02 | Hansoh Bio Llc | Piperidinyl indole derivatives, preparation methods and medicinal uses thereof |
| PE20242005A1 (es) * | 2022-01-24 | 2024-10-03 | Novartis Ag | Derivados espirociclicos de piperidinilo como inhibidores del factor b del complemento y usos de los mismos |
| WO2023237012A1 (zh) * | 2022-06-07 | 2023-12-14 | 正大天晴药业集团股份有限公司 | 双环取代的芳香羧酸类氘代化合物 |
| CN119698414A (zh) * | 2022-06-20 | 2025-03-25 | 深圳信立泰药业股份有限公司 | 一种吲哚-苯基哌啶化合物及其制备方法与应用 |
| CN119546585A (zh) * | 2022-06-23 | 2025-02-28 | 上海济煜医药科技有限公司 | 吲哚化合物的制备、应用及用途 |
| TW202423426A (zh) * | 2022-08-31 | 2024-06-16 | 美商奇努克醫療股份有限公司 | 經取代之吲哚化合物及其使用方法 |
| JP2025530222A (ja) * | 2022-09-10 | 2025-09-11 | 江▲蘇▼豪森▲薬▼▲業▼集▲団▼有限公司 | ２－置換ピペリジン誘導体、その製造方法及び医薬的用途 |
| US20260159497A1 (en) * | 2022-11-14 | 2026-06-11 | Novartis Pharma Ag | Solid forms of a complement factor b inhibitor |
| CN120303261A (zh) * | 2022-11-29 | 2025-07-11 | 上海济煜医药科技有限公司 | 苯并螺环吲哚化合物的制备、应用及用途 |
| WO2024148274A1 (en) * | 2023-01-05 | 2024-07-11 | Apellis Pharmaceuticals, Inc. | Complement inhibition |
| EP4650351A1 (en) * | 2023-01-09 | 2025-11-19 | Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd. | Inhibitor of complement factor b |
| JP2026506078A (ja) * | 2023-02-16 | 2026-02-20 | ハイスーク ファーマシューティカル グループ カンパニー リミテッド | ベンゾアザ芳香環誘導体の塩、結晶形及びその医薬的応用 |
| TW202434240A (zh) * | 2023-02-22 | 2024-09-01 | 大陸商西藏海思科製藥有限公司 | 苯並氮雜芳環衍生物的藥物組合物及其在醫藥上的應用 |
| AU2024261191A1 (en) * | 2023-04-27 | 2025-11-06 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Salt of piperidylindole compound and preparation method therefor |
| EP4739390A1 (en) | 2023-07-04 | 2026-05-13 | Sitala Bio Ltd | 2-(1h-indol-4-yl)methyl)2h-indazole derivatives as factor b inhibitors |
| CN121752557A (zh) | 2023-07-04 | 2026-03-27 | 希塔拉生物有限公司 | 2-(1h-吲哚-4-基)甲基)-异吲哚啉衍生物作为因子b抑制剂 |
| WO2025008516A2 (en) | 2023-07-06 | 2025-01-09 | Sitala Bio Ltd | Novel compounds |
| WO2025008517A1 (en) | 2023-07-06 | 2025-01-09 | Sitala Bio Ltd | Indole derivatives with factor b inhibitory activity |
| CN119371402A (zh) * | 2023-07-26 | 2025-01-28 | 上海美悦生物科技发展有限公司 | 螺环烯基类或氮杂烯基类化合物及其药物组合物、制备方法和用途 |
| TW202517258A (zh) * | 2023-09-20 | 2025-05-01 | 大陸商上海美悦生物科技發展有限公司 | 雜環化合物在製備預防和／或治療腎臟疾病的藥物中的用途 |
| CN122396492A (zh) * | 2023-12-05 | 2026-07-14 | 西藏海思科制药有限公司 | 苯并氮杂芳环衍生物在治疗补体因子b介导的疾病中的用途 |
| WO2025172535A1 (en) | 2024-02-15 | 2025-08-21 | Sitala Bio Ltd | Indole and benzimidazole compounds as factor b inhibitors |
| WO2025256647A1 (zh) * | 2024-06-14 | 2025-12-18 | 润尔眼科药物（广州）有限公司 | 化合物及其医药用途 |
| WO2026008073A1 (zh) * | 2024-07-05 | 2026-01-08 | 南京正大天晴制药有限公司 | 补体因子b抑制剂的剂量组合物 |
| WO2026069246A1 (en) * | 2024-09-30 | 2026-04-02 | Novartis Ag | Complement factor b inhibitors and uses thereof |
| CN121949280A (zh) * | 2024-10-31 | 2026-05-01 | 甫康（上海）健康科技有限责任公司 | 一种多取代吲哚类化合物及其制备方法和用途 |
| GB202500206D0 (en) | 2025-01-08 | 2025-02-19 | Sitala Bio Ltd | Novel compounds |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201406973PA (en) * | 2012-05-04 | 2014-12-30 | Novartis Ag | Complement pathway modulators and uses thereof |
| CN104619698B (zh) * | 2012-06-28 | 2016-08-31 | 诺华股份有限公司 | 吡咯烷衍生物及其作为补体途径调节剂的用途 |
| JO3425B1 (ar) * | 2013-07-15 | 2019-10-20 | Novartis Ag | مشتقات البابيريدينيل-اندول واستخدامها كعامل متمم لمثبطات b |
| MX2018016046A (es) * | 2016-06-27 | 2019-05-02 | Achillion Pharmaceuticals Inc | Quinazolina y compuestos indol para tratar trastornos medicos. |
| KR20230049115A (ko) | 2020-08-07 | 2023-04-12 | 상하이 메이유에 바이오테크 디벨롭먼트 컴퍼니 리미티드 | 보체 인자 b 억제제 및 이의 약학적 조성물, 제조 방법 및 용도 |
| WO2022254362A1 (en) | 2021-06-03 | 2022-12-08 | Novartis Ag | 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and medical uses thereof |
| CN117412955A (zh) | 2021-06-03 | 2024-01-16 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| KR20240024926A (ko) | 2021-06-24 | 2024-02-26 | 신젠타 크롭 프로텍션 아게 | 살충제로서의 2-[3-[1[(퀴나졸린-4-일)아미노]에틸]피라진-2-일]티아졸-5-카르보니트릴 유도체 및 유사한 화합물 |
| WO2023283256A1 (en) | 2021-07-09 | 2023-01-12 | Aligos Therapeutics, Inc. | Anti-viral compounds |
| MX2024001269A (es) | 2021-07-26 | 2024-04-23 | Harvard College | Inhibidores de rock2 y sus usos. |
| AU2022376760A1 (en) * | 2021-10-27 | 2024-05-02 | Hansoh Bio Llc | Piperidinyl indole derivatives, preparation methods and medicinal uses thereof |
| AR127922A1 (es) | 2021-12-15 | 2024-03-13 | Syngenta Crop Protection Ag | Derivados heterocíclicos bicíclicos microbiocidas |
| US20250326757A1 (en) | 2022-05-26 | 2025-10-23 | Astrazeneca Ab | Solid forms of heterocyclylamides as irak4 inhibitors |
-
2022
- 2022-06-03 PE PE2023003178A patent/PE20250114A1/es unknown
- 2022-06-03 KR KR1020237045081A patent/KR20240017004A/ko active Pending
- 2022-06-03 PH PH1/2023/553130A patent/PH12023553130A1/en unknown
- 2022-06-03 JP JP2023574119A patent/JP7895996B2/ja active Active
- 2022-06-03 CA CA3222144A patent/CA3222144A1/en active Pending
- 2022-06-03 IL IL308835A patent/IL308835A/en unknown
- 2022-06-03 BR BR112023025235A patent/BR112023025235A2/pt unknown
- 2022-06-03 WO PCT/US2022/032042 patent/WO2022256586A2/en not_active Ceased
- 2022-06-03 AU AU2022283903A patent/AU2022283903A1/en active Pending
- 2022-06-03 CR CR20230564A patent/CR20230564A/es unknown
- 2022-06-03 MX MX2023014274A patent/MX2023014274A/es unknown
- 2022-06-03 US US18/566,259 patent/US20240287034A1/en active Pending
- 2022-06-03 CN CN202510248844.6A patent/CN120081822A/zh active Pending
- 2022-06-03 EP EP22816892.8A patent/EP4346812A4/en active Pending
-
2023
- 2023-11-30 EC ECSENADI202390260A patent/ECSP23090260A/es unknown
- 2023-11-30 CL CL2023003591A patent/CL2023003591A1/es unknown
- 2023-11-30 DO DO2023000263A patent/DOP2023000263A/es unknown
- 2023-11-30 CO CONC2023/0016557A patent/CO2023016557A2/es unknown
- 2023-11-30 JO JOJO/P/2023/0315A patent/JOP20230315A1/ar unknown
-
2025
- 2025-05-30 US US19/223,498 patent/US12617774B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2024541929A5 (enExample) | ||
| JP2025504859A5 (enExample) | ||
| JP2016535042A5 (enExample) | ||
| JP2015515976A5 (enExample) | ||
| JP2021507900A5 (enExample) | ||
| JP2016514719A5 (enExample) | ||
| JP2016526576A5 (enExample) | ||
| JP2020537657A5 (enExample) | ||
| JP2017505808A5 (enExample) | ||
| JP2013509431A5 (enExample) | ||
| RU2016115082A (ru) | Замещенные аминопиримидиновые соединения и способы их использования | |
| CA2479126A1 (en) | Combination treatments for chemokine-mediated diseases | |
| JP2021500340A5 (enExample) | ||
| JP2016514718A5 (enExample) | ||
| JP2013533883A5 (enExample) | ||
| JP2017512786A5 (enExample) | ||
| JP2017538721A5 (enExample) | ||
| JP2020502047A5 (enExample) | ||
| RU2009135080A (ru) | Имидазохинолины в качестве двойных ингибиторов липидкиназы и mtor | |
| JP2007515489A5 (enExample) | ||
| JP2023519824A5 (enExample) | ||
| JP2025503448A5 (enExample) | ||
| JP2017532294A5 (enExample) | ||
| JP2025508272A5 (enExample) | ||
| JP2021510692A5 (enExample) |