JP2024520643A - ナトリウムチャネルの調節因子としてのヒドロキシ及び(ハロ)アルコキシ置換テトラヒドロフラン - Google Patents
ナトリウムチャネルの調節因子としてのヒドロキシ及び(ハロ)アルコキシ置換テトラヒドロフラン Download PDFInfo
- Publication number
- JP2024520643A JP2024520643A JP2023574370A JP2023574370A JP2024520643A JP 2024520643 A JP2024520643 A JP 2024520643A JP 2023574370 A JP2023574370 A JP 2023574370A JP 2023574370 A JP2023574370 A JP 2023574370A JP 2024520643 A JP2024520643 A JP 2024520643A
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- Prior art keywords
- pain
- pharma
- compound
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- ceutically acceptable
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163197141P | 2021-06-04 | 2021-06-04 | |
| US63/197,141 | 2021-06-04 | ||
| PCT/US2022/072758 WO2022256842A1 (en) | 2021-06-04 | 2022-06-03 | Hydroxy and (halo)alkoxy substituted tetrahydrofurans as modulators of sodium channels |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024520643A true JP2024520643A (ja) | 2024-05-24 |
| JPWO2022256842A5 JPWO2022256842A5 (https=) | 2025-06-11 |
| JP2024520643A5 JP2024520643A5 (https=) | 2025-06-11 |
Family
ID=82482756
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023574370A Pending JP2024520643A (ja) | 2021-06-04 | 2022-06-03 | ナトリウムチャネルの調節因子としてのヒドロキシ及び(ハロ)アルコキシ置換テトラヒドロフラン |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20240294512A1 (https=) |
| EP (1) | EP4347033A1 (https=) |
| JP (1) | JP2024520643A (https=) |
| CN (1) | CN117858875A (https=) |
| AU (1) | AU2022286511A1 (https=) |
| CA (1) | CA3221960A1 (https=) |
| WO (1) | WO2022256842A1 (https=) |
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| UY40234A (es) | 2022-04-22 | 2023-11-15 | Vertex Pharma | Compuestos heteroarilo para el tratamiento del dolor |
| CN119585260A (zh) * | 2022-08-24 | 2025-03-07 | 江苏恒瑞医药股份有限公司 | 杂环类化合物、其制备方法及其在医药上的应用 |
| JP2025529931A (ja) * | 2022-08-28 | 2025-09-09 | シャンハイ ホイルン ファーマシューティカル カンパニー リミテッド | ナトリウムチャネル調節剤及びその応用 |
| CN120569377A (zh) * | 2023-01-06 | 2025-08-29 | 海思科医药集团股份有限公司 | 一种四氢噻吩衍生物及其在医药上的应用 |
| CN116082363B (zh) * | 2023-02-16 | 2025-11-21 | 西安交通大学 | 一种雷帕霉素40-位羟基的烷基化合成方法 |
| WO2024188367A1 (zh) * | 2023-03-10 | 2024-09-19 | 西藏海思科制药有限公司 | 一种四氢呋喃衍生物及其在医药上的应用 |
| WO2024217557A1 (zh) * | 2023-04-19 | 2024-10-24 | 武汉人福创新药物研发中心有限公司 | 取代的四氢呋喃作为Nav1.8抑制剂 |
| CN119371405A (zh) | 2023-07-26 | 2025-01-28 | 上海闻耐医药科技有限公司 | 多取代吡咯烷类衍生物、其制备方法及用途 |
| WO2025067219A1 (zh) * | 2023-09-25 | 2025-04-03 | 江苏恒瑞医药股份有限公司 | 杂环类化合物、其制备方法及其在医药上的应用 |
| WO2025090465A1 (en) * | 2023-10-23 | 2025-05-01 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| WO2025090480A1 (en) * | 2023-10-23 | 2025-05-01 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| WO2025092901A1 (en) * | 2023-11-01 | 2025-05-08 | Insilico Medicine Ip Limited | Novel compounds as modulators of sodium channels and uses thereof |
| TW202535352A (zh) * | 2023-11-02 | 2025-09-16 | 大陸商陽光安津(南京)生物醫藥科技有限公司 | 化合物、組合物及其方法 |
| WO2025140260A1 (zh) * | 2023-12-26 | 2025-07-03 | 南京清普生物科技有限公司 | 一种新型钠通道调节剂 |
| WO2025162194A1 (zh) * | 2024-01-31 | 2025-08-07 | 上海汇伦医药股份有限公司 | 钠通道调节剂新化合物及其应用 |
| WO2025168043A1 (zh) * | 2024-02-08 | 2025-08-14 | 上海枢境生物科技有限公司 | 并环类衍生物、制备方法及其用途 |
| CN120040431A (zh) * | 2024-02-23 | 2025-05-27 | 山东盛迪医药有限公司 | 一种取代四氢呋喃衍生物的可药用盐、其结晶形式及用途 |
| CN120040429B (zh) * | 2024-02-23 | 2026-03-31 | 山东盛迪医药有限公司 | 一种取代四氢呋喃衍生物的结晶形式及其用途 |
| WO2025176204A1 (zh) * | 2024-02-23 | 2025-08-28 | 江苏恒瑞医药股份有限公司 | 一种吡啶-n-氧化物衍生物的结晶形式、盐及其用途 |
| CN120774914A (zh) * | 2024-04-03 | 2025-10-14 | 武汉人福创新药物研发中心有限公司 | 作为Nav1.8抑制剂的四氢呋喃吡啶酮类化合物 |
| WO2025223430A1 (zh) * | 2024-04-22 | 2025-10-30 | 晶新医药研发(上海)有限公司 | 一种五元杂环类化合物、药物组合物及其应用 |
| WO2025223433A1 (zh) * | 2024-04-22 | 2025-10-30 | 晶新医药研发(上海)有限公司 | 一种五元杂环类化合物、药物组合物及其应用 |
| WO2025223429A1 (zh) * | 2024-04-22 | 2025-10-30 | 晶新医药研发(上海)有限公司 | 一种五元杂环类化合物、药物组合物及其应用 |
| CN118388466A (zh) * | 2024-04-23 | 2024-07-26 | 安润医药科技(苏州)有限公司 | 作钠通道调节剂的酰胺衍生物及其用途 |
| WO2025252109A1 (zh) * | 2024-06-04 | 2025-12-11 | 成都苑东生物制药股份有限公司 | 一种取代四氢呋喃类衍生物、其制备方法及用途 |
| US20260001877A1 (en) * | 2024-06-28 | 2026-01-01 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| CN119143737B (zh) * | 2024-11-18 | 2025-07-18 | 嘉兴安帝康生物科技有限公司 | 四氢呋喃甲酰胺类钠通道调节剂及其在医药上的应用 |
| CN119285621B (zh) * | 2024-12-13 | 2025-07-18 | 嘉兴安帝康生物科技有限公司 | 作为钠通道调节剂的四氢呋喃甲酰胺类化合物及其在医药上的应用 |
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| CN112457294B (zh) | 2021-01-27 | 2021-06-04 | 上海济煜医药科技有限公司 | 一种作为NaV1.8阻滞剂的化合物及其制备方法和用途 |
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2022
- 2022-06-03 JP JP2023574370A patent/JP2024520643A/ja active Pending
- 2022-06-03 CN CN202280053167.7A patent/CN117858875A/zh active Pending
- 2022-06-03 EP EP22740730.1A patent/EP4347033A1/en active Pending
- 2022-06-03 US US18/566,305 patent/US20240294512A1/en active Pending
- 2022-06-03 WO PCT/US2022/072758 patent/WO2022256842A1/en not_active Ceased
- 2022-06-03 AU AU2022286511A patent/AU2022286511A1/en active Pending
- 2022-06-03 CA CA3221960A patent/CA3221960A1/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004509881A (ja) * | 2000-09-19 | 2004-04-02 | メルク シャープ エンド ドーム リミテッド | テトラヒドロフラン誘導体および治療薬としてのその使用 |
| JP2020526561A (ja) * | 2017-07-11 | 2020-08-31 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | ナトリウムチャネルのモジュレーターとしてのカルボキサミド |
| WO2020092667A1 (en) * | 2018-11-02 | 2020-05-07 | Merck Sharp & Dohme Corp. | 2-amino-n-heteroaryl-nicotinamides as nav1.8 inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022256842A1 (en) | 2022-12-08 |
| US20240294512A1 (en) | 2024-09-05 |
| EP4347033A1 (en) | 2024-04-10 |
| AU2022286511A1 (en) | 2023-11-30 |
| CN117858875A (zh) | 2024-04-09 |
| CA3221960A1 (en) | 2022-12-08 |
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