CN117858875A - 羟基和(卤代)烷氧基取代的四氢呋喃作为钠通道调节剂 - Google Patents

羟基和(卤代)烷氧基取代的四氢呋喃作为钠通道调节剂 Download PDF

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Publication number
CN117858875A
CN117858875A CN202280053167.7A CN202280053167A CN117858875A CN 117858875 A CN117858875 A CN 117858875A CN 202280053167 A CN202280053167 A CN 202280053167A CN 117858875 A CN117858875 A CN 117858875A
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pain
pharmaceutically acceptable
acceptable salt
compound
mmol
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Pending
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CN202280053167.7A
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English (en)
Chinese (zh)
Inventor
E·M·拜克
R·布林
G·埃切巴里亚贾迪
D·斯塔莫斯
Y·施密特
J·蓬蒂洛
S·A·汤姆森
D·M·肖
N·M·艾哈迈德
L·M·卡瓦略梅雷莱斯
S·斯卡拉特
S·S·哈迪达鲁阿
T·D·纽伯特
D·J·赫雷
S·J·杜兰特
C·威伊
A·N·维拉尼
K·诺斯
B·珈兰
R·M·尼格泰尔
E·I·查迪克
J·L·潘德
B·A·苏萨
F·皮耶拉尔
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Publication of CN117858875A publication Critical patent/CN117858875A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CN202280053167.7A 2021-06-04 2022-06-03 羟基和(卤代)烷氧基取代的四氢呋喃作为钠通道调节剂 Pending CN117858875A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163197141P 2021-06-04 2021-06-04
US63/197,141 2021-06-04
PCT/US2022/072758 WO2022256842A1 (en) 2021-06-04 2022-06-03 Hydroxy and (halo)alkoxy substituted tetrahydrofurans as modulators of sodium channels

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CN117858875A true CN117858875A (zh) 2024-04-09

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CN202280053167.7A Pending CN117858875A (zh) 2021-06-04 2022-06-03 羟基和(卤代)烷氧基取代的四氢呋喃作为钠通道调节剂

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US (1) US20240294512A1 (https=)
EP (1) EP4347033A1 (https=)
JP (1) JP2024520643A (https=)
CN (1) CN117858875A (https=)
AU (1) AU2022286511A1 (https=)
CA (1) CA3221960A1 (https=)
WO (1) WO2022256842A1 (https=)

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CN119143737A (zh) * 2024-11-18 2024-12-17 嘉兴安帝康生物科技有限公司 四氢呋喃甲酰胺类钠通道调节剂及其在医药上的应用
WO2025223433A1 (zh) * 2024-04-22 2025-10-30 晶新医药研发（上海）有限公司 一种五元杂环类化合物、药物组合物及其应用
WO2025223429A1 (zh) * 2024-04-22 2025-10-30 晶新医药研发（上海）有限公司 一种五元杂环类化合物、药物组合物及其应用
WO2025223193A1 (zh) * 2024-04-23 2025-10-30 安润医药科技（苏州）有限公司 作钠通道调节剂的酰胺衍生物及其用途
WO2025223430A1 (zh) * 2024-04-22 2025-10-30 晶新医药研发（上海）有限公司 一种五元杂环类化合物、药物组合物及其应用
WO2025252109A1 (zh) * 2024-06-04 2025-12-11 成都苑东生物制药股份有限公司 一种取代四氢呋喃类衍生物、其制备方法及用途

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UY40234A (es) 2022-04-22 2023-11-15 Vertex Pharma Compuestos heteroarilo para el tratamiento del dolor
CN119585260A (zh) * 2022-08-24 2025-03-07 江苏恒瑞医药股份有限公司 杂环类化合物、其制备方法及其在医药上的应用
JP2025529931A (ja) * 2022-08-28 2025-09-09 シャンハイ ホイルン ファーマシューティカル カンパニー リミテッド ナトリウムチャネル調節剤及びその応用
CN120569377A (zh) * 2023-01-06 2025-08-29 海思科医药集团股份有限公司 一种四氢噻吩衍生物及其在医药上的应用
CN116082363B (zh) * 2023-02-16 2025-11-21 西安交通大学 一种雷帕霉素40-位羟基的烷基化合成方法
WO2024188367A1 (zh) * 2023-03-10 2024-09-19 西藏海思科制药有限公司 一种四氢呋喃衍生物及其在医药上的应用
WO2024217557A1 (zh) * 2023-04-19 2024-10-24 武汉人福创新药物研发中心有限公司 取代的四氢呋喃作为Nav1.8抑制剂
CN119371405A (zh) 2023-07-26 2025-01-28 上海闻耐医药科技有限公司 多取代吡咯烷类衍生物、其制备方法及用途
WO2025067219A1 (zh) * 2023-09-25 2025-04-03 江苏恒瑞医药股份有限公司 杂环类化合物、其制备方法及其在医药上的应用
WO2025090465A1 (en) * 2023-10-23 2025-05-01 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
WO2025090480A1 (en) * 2023-10-23 2025-05-01 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
WO2025092901A1 (en) * 2023-11-01 2025-05-08 Insilico Medicine Ip Limited Novel compounds as modulators of sodium channels and uses thereof
TW202535352A (zh) * 2023-11-02 2025-09-16 大陸商陽光安津（南京）生物醫藥科技有限公司 化合物、組合物及其方法
WO2025140260A1 (zh) * 2023-12-26 2025-07-03 南京清普生物科技有限公司 一种新型钠通道调节剂
WO2025162194A1 (zh) * 2024-01-31 2025-08-07 上海汇伦医药股份有限公司 钠通道调节剂新化合物及其应用
WO2025168043A1 (zh) * 2024-02-08 2025-08-14 上海枢境生物科技有限公司 并环类衍生物、制备方法及其用途
CN120040431A (zh) * 2024-02-23 2025-05-27 山东盛迪医药有限公司 一种取代四氢呋喃衍生物的可药用盐、其结晶形式及用途
CN120040429B (zh) * 2024-02-23 2026-03-31 山东盛迪医药有限公司 一种取代四氢呋喃衍生物的结晶形式及其用途
WO2025176204A1 (zh) * 2024-02-23 2025-08-28 江苏恒瑞医药股份有限公司 一种吡啶-n-氧化物衍生物的结晶形式、盐及其用途
CN120774914A (zh) * 2024-04-03 2025-10-14 武汉人福创新药物研发中心有限公司 作为Nav1.8抑制剂的四氢呋喃吡啶酮类化合物
US20260001877A1 (en) * 2024-06-28 2026-01-01 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
CN119285621B (zh) * 2024-12-13 2025-07-18 嘉兴安帝康生物科技有限公司 作为钠通道调节剂的四氢呋喃甲酰胺类化合物及其在医药上的应用

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WO2025223429A1 (zh) * 2024-04-22 2025-10-30 晶新医药研发（上海）有限公司 一种五元杂环类化合物、药物组合物及其应用
WO2025223430A1 (zh) * 2024-04-22 2025-10-30 晶新医药研发（上海）有限公司 一种五元杂环类化合物、药物组合物及其应用
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CN119143737A (zh) * 2024-11-18 2024-12-17 嘉兴安帝康生物科技有限公司 四氢呋喃甲酰胺类钠通道调节剂及其在医药上的应用

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