|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
|
ES2728782T3
(es)
|
2012-05-25 |
2019-10-28 |
Univ California |
Métodos y composiciones para la modificación de ADN objetivo dirigida por ARN y para la modulación de la transcripción dirigida por ARN
|
|
KR102955556B1
(ko)
|
2012-12-12 |
2026-04-22 |
더 브로드 인스티튜트, 인코퍼레이티드 |
서열 조작을 위한 crispr-cas 성분 시스템, 방법 및 조성물
|
|
MX380562B
(es)
|
2012-12-12 |
2025-03-12 |
Broad Inst Inc |
Modificaciones de sistemas, métodos y composiciones guía optimizadas para la manipulación de secuencias.
|
|
WO2014093694A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Crispr-cas nickase systems, methods and compositions for sequence manipulation in eukaryotes
|
|
CN105209621B
(zh)
|
2012-12-12 |
2021-05-25 |
布罗德研究所有限公司 |
对用于序列操纵的改进的系统、方法和酶组合物进行的工程化和优化
|
|
PT2931898E
(pt)
|
2012-12-12 |
2016-06-16 |
Harvard College |
Manipulação e otimização de sistemas, métodos e composições para manipulação de sequências com domínios funcionais
|
|
ES2749624T3
(es)
|
2013-03-14 |
2020-03-23 |
Caribou Biosciences Inc |
Composiciones y métodos de ácidos nucleicos dirigidos a ácido nucleico
|
|
WO2014204725A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation
|
|
CN111218447B
(zh)
|
2013-11-07 |
2024-10-11 |
爱迪塔斯医药有限公司 |
使用统治型gRNA的CRISPR相关方法和组合物
|
|
EP3835419A1
(en)
|
2013-12-12 |
2021-06-16 |
The Regents of The University of California |
Methods and compositions for modifying a single stranded target nucleic acid
|
|
CA2932439A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute, Inc. |
Crispr-cas systems and methods for altering expression of gene products, structural information and inducible modular cas enzymes
|
|
WO2015089473A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
|
|
EP3089989B1
(en)
|
2013-12-31 |
2020-06-24 |
The Regents of The University of California |
Cas9 crystals and methods of use thereof
|
|
EP3180426B1
(en)
|
2014-08-17 |
2019-12-25 |
The Broad Institute, Inc. |
Genome editing using cas9 nickases
|
|
WO2016036754A1
(en)
|
2014-09-02 |
2016-03-10 |
The Regents Of The University Of California |
Methods and compositions for rna-directed target dna modification
|
|
US11053271B2
(en)
|
2014-12-23 |
2021-07-06 |
The Regents Of The University Of California |
Methods and compositions for nucleic acid integration
|
|
MX2017014560A
(es)
|
2015-05-15 |
2018-03-01 |
Pioneer Hi Bred Int |
Caracterizacion rapida de sistemas de endonucleasa cas, secuencias pam y elementos arn de guia.
|
|
US10392607B2
(en)
|
2015-06-03 |
2019-08-27 |
The Regents Of The University Of California |
Cas9 variants and methods of use thereof
|
|
US20160362667A1
(en)
|
2015-06-10 |
2016-12-15 |
Caribou Biosciences, Inc. |
CRISPR-Cas Compositions and Methods
|
|
AU2016279062A1
(en)
|
2015-06-18 |
2019-03-28 |
Omar O. Abudayyeh |
Novel CRISPR enzymes and systems
|
|
US9790490B2
(en)
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
CA3012631A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
|
US9580727B1
(en)
|
2015-08-07 |
2017-02-28 |
Caribou Biosciences, Inc. |
Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides
|
|
US11008555B2
(en)
|
2015-09-17 |
2021-05-18 |
The Regents Of The University Of California |
Variant Cas9 polypeptides comprising internal insertions
|
|
CN116814590A
(zh)
|
2015-10-22 |
2023-09-29 |
布罗德研究所有限公司 |
Vi-b型crispr酶和系统
|
|
EP3350327B1
(en)
|
2015-10-23 |
2018-09-26 |
Caribou Biosciences, Inc. |
Engineered crispr class 2 cross-type nucleic-acid targeting nucleic acids
|
|
EP3564371B1
(en)
|
2015-12-04 |
2020-05-27 |
Caribou Biosciences, Inc. |
Engineered nucleic-acid targeting nucleic acids
|
|
EP3390624A4
(en)
|
2015-12-18 |
2019-07-10 |
The Regents of The University of California |
Modified site-directed modifying polypeptides and methods of use thereof
|
|
WO2017106657A1
(en)
|
2015-12-18 |
2017-06-22 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
|
KR20260004568A
(ko)
|
2016-04-19 |
2026-01-08 |
더 브로드 인스티튜트, 인코퍼레이티드 |
신규한 crispr 효소 및 시스템
|
|
CA3026110A1
(en)
|
2016-04-19 |
2017-11-02 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
AU2017283713B2
(en)
|
2016-06-17 |
2021-04-08 |
Massachusetts Institute Of Technology |
Type VI CRISPR orthologs and systems
|
|
WO2018035387A1
(en)
|
2016-08-17 |
2018-02-22 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
US11352647B2
(en)
|
2016-08-17 |
2022-06-07 |
The Broad Institute, Inc. |
Crispr enzymes and systems
|
|
JP2019532644A
(ja)
|
2016-09-30 |
2019-11-14 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
Rna誘導型核酸修飾酵素及びその使用方法
|
|
CA3038982A1
(en)
|
2016-09-30 |
2018-04-05 |
The Regents Of The University Of California |
Rna-guided nucleic acid modifying enzymes and methods of use thereof
|
|
EP3526326A4
(en)
|
2016-10-12 |
2020-07-29 |
The Regents of The University of Colorado, A Body Corporate |
NEW MODIFIED AND CHEMERICAL NUCLEASES
|
|
US11180778B2
(en)
|
2016-11-11 |
2021-11-23 |
The Regents Of The University Of California |
Variant RNA-guided polypeptides and methods of use
|
|
US9816093B1
(en)
|
2016-12-06 |
2017-11-14 |
Caribou Biosciences, Inc. |
Engineered nucleic acid-targeting nucleic acids
|
|
CN110959039B
(zh)
|
2017-03-15 |
2025-03-14 |
博德研究所 |
新型cas13b直向同源物crispr酶和系统
|
|
EP3526324B1
(en)
|
2017-03-28 |
2021-08-25 |
Locanabio, Inc. |
Crispr-associated (cas) protein
|
|
AU2018251801B2
(en)
|
2017-04-12 |
2024-11-07 |
Massachusetts Institute Of Technology |
Novel type VI CRISPR orthologs and systems
|
|
US11692184B2
(en)
|
2017-05-16 |
2023-07-04 |
The Regents Of The University Of California |
Thermostable RNA-guided endonucleases and methods of use thereof
|
|
US20200140835A1
(en)
|
2017-06-06 |
2020-05-07 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 Nucleases
|
|
CN111511906A
(zh)
|
2017-06-23 |
2020-08-07 |
因思科瑞普特公司 |
核酸引导性核酸酶
|
|
WO2019005866A1
(en)
|
2017-06-26 |
2019-01-03 |
The Broad Institute, Inc. |
NEW TYPE VI CRISPR ORTHOLOGISTS AND ASSOCIATED SYSTEMS
|
|
US10392616B2
(en)
|
2017-06-30 |
2019-08-27 |
Arbor Biotechnologies, Inc. |
CRISPR RNA targeting enzymes and systems and uses thereof
|
|
WO2019018423A1
(en)
|
2017-07-17 |
2019-01-24 |
The Broad Institute, Inc. |
NEW TYPE VI CRISPR ORTHOLOGISTS AND ASSOCIATED SYSTEMS
|
|
US20200115688A1
(en)
|
2017-08-15 |
2020-04-16 |
The Regents Of The University Of California |
Compositions and methods for enhancing genome editing
|
|
KR20200074104A
(ko)
|
2017-10-04 |
2020-06-24 |
더 브로드 인스티튜트, 인코퍼레이티드 |
표적화된 핵산 편집을 위한 시스템, 방법, 및 조성물
|
|
CN117487776A
(zh)
|
2017-11-01 |
2024-02-02 |
加利福尼亚大学董事会 |
Casz组合物和使用方法
|
|
WO2019089808A1
(en)
|
2017-11-01 |
2019-05-09 |
The Regents Of The University Of California |
Class 2 crispr/cas compositions and methods of use
|
|
WO2019089804A1
(en)
|
2017-11-01 |
2019-05-09 |
The Regents Of The University Of California |
Casy compositions and methods of use
|
|
EP3704254A4
(en)
|
2017-11-01 |
2021-09-01 |
The Regents of The University of California |
CAS12C COMPOSITIONS AND METHOD OF USE
|
|
US10253365B1
(en)
|
2017-11-22 |
2019-04-09 |
The Regents Of The University Of California |
Type V CRISPR/Cas effector proteins for cleaving ssDNAs and detecting target DNAs
|
|
WO2019126762A2
(en)
|
2017-12-22 |
2019-06-27 |
The Broad Institute, Inc. |
Cas12a systems, methods, and compositions for targeted rna base editing
|
|
WO2019126774A1
(en)
|
2017-12-22 |
2019-06-27 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
WO2019173248A1
(en)
|
2018-03-07 |
2019-09-12 |
Caribou Biosciences, Inc. |
Engineered nucleic acid-targeting nucleic acids
|
|
DK3765616T3
(da)
|
2018-03-14 |
2023-08-21 |
Arbor Biotechnologies Inc |
Nye enzymer og systemer målrettet crispr dna og rna
|
|
PL3765615T3
(pl)
*
|
2018-03-14 |
2023-11-13 |
Arbor Biotechnologies, Inc. |
Nowe enzymy i układy crispr ukierunkowane na dna
|
|
WO2019222555A1
(en)
|
2018-05-16 |
2019-11-21 |
Arbor Biotechnologies, Inc. |
Novel crispr-associated systems and components
|
|
JP6965466B2
(ja)
|
2018-06-13 |
2021-11-10 |
カリブー・バイオサイエンシーズ・インコーポレイテッド |
操作されたカスケード構成要素およびカスケード複合体
|
|
US20210269782A1
(en)
|
2018-06-26 |
2021-09-02 |
The Regents Of The University Of California |
Rna-guided effector proteins and methods of use thereof
|
|
WO2020018142A1
(en)
|
2018-07-16 |
2020-01-23 |
Arbor Biotechnologies, Inc. |
Novel crispr dna targeting enzymes and systems
|
|
US20210284981A1
(en)
|
2018-07-24 |
2021-09-16 |
The Regents Of The University Of California |
Rna-guided nucleic acid modifying enzymes and methods of use thereof
|
|
EP3830256A2
(en)
|
2018-07-31 |
2021-06-09 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
WO2020028729A1
(en)
|
2018-08-01 |
2020-02-06 |
Mammoth Biosciences, Inc. |
Programmable nuclease compositions and methods of use thereof
|
|
CA3106035A1
(en)
|
2018-08-07 |
2020-02-13 |
The Broad Institute, Inc. |
Cas12b enzymes and systems
|
|
EP3841205A4
(en)
|
2018-08-22 |
2022-08-17 |
The Regents of The University of California |
VARIANT TYPE V CRISPR/CAS EFFECTOR POLYPEPTIDES AND METHODS OF USE THEREOF
|
|
WO2020086475A1
(en)
|
2018-10-22 |
2020-04-30 |
Inscripta, Inc. |
Engineered enzymes
|
|
EP3931313A2
(en)
|
2019-01-04 |
2022-01-05 |
Mammoth Biosciences, Inc. |
Programmable nuclease improvements and compositions and methods for nucleic acid amplification and detection
|
|
WO2020180699A1
(en)
|
2019-03-01 |
2020-09-10 |
Arbor Biotechnologies, Inc. |
Novel crispr dna targeting enzymes and systems
|
|
EP3935155A4
(en)
|
2019-03-07 |
2022-11-23 |
The Regents of The University of California |
CRISPR-CAS EFFECTOR POLYPEPTIDES AND METHODS OF USE
|
|
EP4219700A1
(en)
|
2019-03-07 |
2023-08-02 |
The Regents of the University of California |
Crispr-cas effector polypeptides and methods of use thereof
|
|
US20220154222A1
(en)
|
2019-03-14 |
2022-05-19 |
The Broad Institute, Inc. |
Novel nucleic acid modifiers
|
|
US12534714B2
(en)
|
2019-03-18 |
2026-01-27 |
The Broad Institute, Inc. |
Type VII CRISPR proteins and systems
|
|
WO2020191241A1
(en)
*
|
2019-03-19 |
2020-09-24 |
The Broad Institute, Inc. |
Methods and compositions for editing nucleotide sequences
|
|
US12624063B2
(en)
|
2019-03-22 |
2026-05-12 |
The Regents Of The University Of California |
Compositions and methods for modification of target molecules
|
|
US20220162649A1
(en)
|
2019-04-01 |
2022-05-26 |
The Broad Institute, Inc. |
Novel nucleic acid modifiers
|
|
WO2020223634A1
(en)
|
2019-05-01 |
2020-11-05 |
Mammoth Biosciences, Inc. |
Programmable nucleases and methods of use
|
|
WO2020247883A2
(en)
|
2019-06-07 |
2020-12-10 |
Scribe Therapeutics Inc. |
Deep mutational evolution of biomolecules
|
|
SG11202113253SA
(en)
|
2019-06-07 |
2021-12-30 |
Scribe Therapeutics Inc |
Engineered casx systems
|
|
EP3983536A4
(en)
|
2019-06-14 |
2023-11-29 |
Arbor Biotechnologies, Inc. |
NOVEL CRISPR DNA TARGETING ENZYMES AND SYSTEMS
|
|
WO2021007177A1
(en)
|
2019-07-08 |
2021-01-14 |
The Regents Of The University Of California |
Variant type v crispr/cas effector polypeptides and methods of use thereof
|
|
CN114206376A
(zh)
|
2019-07-11 |
2022-03-18 |
阿伯生物技术公司 |
新型crispr dna靶向酶及系统
|
|
US20230016656A1
(en)
|
2019-08-27 |
2023-01-19 |
Arbor Biotechnologies, Inc. |
Novel crispr dna targeting enzymes and systems
|
|
EP4025588A4
(en)
|
2019-09-05 |
2023-09-06 |
Arbor Biotechnologies, Inc. |
NOVEL CRISPR DNA TARGETING ENZYMES AND SYSTEMS
|
|
US12460190B2
(en)
|
2019-09-09 |
2025-11-04 |
Arbor Biotechnologies, Inc. |
CRISPR DNA targeting enzymes and systems
|
|
US20230025039A1
(en)
|
2019-09-20 |
2023-01-26 |
The Broad Institute, Inc. |
Novel type vi crispr enzymes and systems
|
|
JP7785002B2
(ja)
*
|
2019-11-05 |
2025-12-12 |
ペアーワイズ プランツ サービシズ, インコーポレイテッド |
対立遺伝子のrnaにコードされたdnaの置換のための組成物および方法
|
|
AU2020397041A1
(en)
|
2019-12-04 |
2022-06-09 |
Arbor Biotechnologies, Inc. |
Compositions comprising a nuclease and uses thereof
|
|
AU2020402526B2
(en)
|
2019-12-10 |
2025-01-23 |
Inscripta, Inc. |
Novel MAD nucleases
|
|
US10704033B1
(en)
|
2019-12-13 |
2020-07-07 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
WO2021133829A1
(en)
|
2019-12-23 |
2021-07-01 |
The Regents Of The University Of California |
Crispr-cas effector polypeptides and methods of use thereof
|
|
CN115698278B
(zh)
*
|
2020-03-31 |
2025-10-17 |
阿伯生物技术公司 |
包含Cas12i2变体多肽的组合物及其用途
|