JP2024520522A - ムチン５ＡＣ（ＭＵＣ５ＡＣ）の発現を阻害するためのＲＮＡｉ剤、その組成物、及び使用方法 - Google Patents

ムチン５ＡＣ（ＭＵＣ５ＡＣ）の発現を阻害するためのＲＮＡｉ剤、その組成物、及び使用方法 Download PDF

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JP2024520522A
JP2024520522A JP2023573300A JP2023573300A JP2024520522A JP 2024520522 A JP2024520522 A JP 2024520522A JP 2023573300 A JP2023573300 A JP 2023573300A JP 2023573300 A JP2023573300 A JP 2023573300A JP 2024520522 A JP2024520522 A JP 2024520522A
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rnai agent
nucleotides
muc5ac
sense strand
antisense strand
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JP2024520522A5 (enExample
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ダブリュ．バッシュ エリック
ニコラス アンソニー
エム．シーネベック カジ
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アローヘッド ファーマシューティカルズ インコーポレイテッド
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
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    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • A—HUMAN NECESSITIES
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3533—Halogen
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

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JP2023573300A 2021-05-28 2022-05-25 ムチン５ＡＣ（ＭＵＣ５ＡＣ）の発現を阻害するためのＲＮＡｉ剤、その組成物、及び使用方法 Pending JP2024520522A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163194370P 2021-05-28 2021-05-28
US63/194,370 2021-05-28
PCT/US2022/030969 WO2022251394A1 (en) 2021-05-28 2022-05-25 Rnai agents for inhibiting expression of mucin 5ac (muc5ac), compositions thereof, and methods of use

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JP2024520522A true JP2024520522A (ja) 2024-05-24
JP2024520522A5 JP2024520522A5 (enExample) 2025-06-02

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JP2023573300A Pending JP2024520522A (ja) 2021-05-28 2022-05-25 ムチン５ＡＣ（ＭＵＣ５ＡＣ）の発現を阻害するためのＲＮＡｉ剤、その組成物、及び使用方法

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US (1) US12365897B2 (enExample)
EP (1) EP4352229A4 (enExample)
JP (1) JP2024520522A (enExample)
KR (1) KR20240014067A (enExample)
CN (1) CN117858949A (enExample)
AU (1) AU2022280863A1 (enExample)
BR (1) BR112023024615A2 (enExample)
CA (1) CA3218815A1 (enExample)
CL (1) CL2023003505A1 (enExample)
CO (1) CO2023016058A2 (enExample)
IL (1) IL308883A (enExample)
MX (1) MX2023014026A (enExample)
PE (1) PE20250265A1 (enExample)
TW (1) TW202313068A (enExample)
WO (1) WO2022251394A1 (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024158905A1 (en) * 2023-01-24 2024-08-02 Ohio State Innovation Foundation Muc5ac in pancreatic ductal adenocarcinoma
WO2025128462A1 (en) * 2023-12-12 2025-06-19 Eli Lilly And Company Novel therapeutic delivery moieties and uses thereof

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JP2002537828A (ja) 1999-03-10 2002-11-12 フォゲン リミティド 細胞への物質のデリバリー
JP2006507841A (ja) * 2002-11-14 2006-03-09 ダーマコン， インコーポレイテッド 機能的ｓｉＲＮＡおよび超機能的ｓｉＲＮＡ
EP2412826B1 (en) * 2004-05-07 2014-01-08 Celera Corporation Genetic polymorphism associated with liver fibrosis methods of detection and uses thereof
BRPI0715375A2 (pt) 2006-08-18 2013-06-18 Hoffmann La Roche policonjugados para distribuiÇço in vivo de polinucleotÍdeos
EP2377934A4 (en) * 2008-12-12 2012-09-26 Kureha Corp PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF TUMOR AND ASTHMA
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KR20140051357A (ko) 2011-08-26 2014-04-30 애로우헤드 리서치 코오포레이션 Ｉｎ Ｖｉｖｏ 핵산 전달용 폴리(비닐 에스테르) 고분자
AU2012377385A1 (en) 2012-04-18 2014-01-23 Arrowhead Research Corporation Poly(acrylate) polymers for in vivo nucleic acid delivery
US9452228B2 (en) * 2013-04-01 2016-09-27 Immunomedics, Inc. Antibodies reactive with an epitope located in the N-terminal region of MUC5AC comprising cysteine-rich subdomain 2 (Cys2)
WO2016003869A1 (en) * 2014-06-30 2016-01-07 Immunomedics, Inc. Antibodies reactive with an epitope located in the n-terminal region of muc5ac comprising cysteine-rich subdomain 2 (cys2)
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US11040056B2 (en) * 2018-05-11 2021-06-22 The University Of North Carolina At Chapel Hill Benzimidazoles that enhance the activity of oligonucleotides

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MX2023014026A (es) 2023-12-12
AU2022280863A1 (en) 2023-11-30
IL308883A (en) 2024-01-01
US20230002767A1 (en) 2023-01-05
EP4352229A1 (en) 2024-04-17
PE20250265A1 (es) 2025-01-29
EP4352229A4 (en) 2025-06-25
US12365897B2 (en) 2025-07-22
CA3218815A1 (en) 2022-12-01
KR20240014067A (ko) 2024-01-31
CL2023003505A1 (es) 2024-10-04
AU2022280863A9 (en) 2023-12-07
WO2022251394A8 (en) 2023-06-22
CO2023016058A2 (es) 2023-12-11
WO2022251394A1 (en) 2022-12-01
BR112023024615A2 (pt) 2024-02-20
CN117858949A (zh) 2024-04-09
TW202313068A (zh) 2023-04-01

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