JP2024515301A - 多重特異性及び一価のｉｇｇ分子の会合における鎖対形成の静電ステアリングにおけるバランスのとれた電荷分布 - Google Patents

多重特異性及び一価のｉｇｇ分子の会合における鎖対形成の静電ステアリングにおけるバランスのとれた電荷分布 Download PDF

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JP2024515301A
JP2024515301A JP2023563833A JP2023563833A JP2024515301A JP 2024515301 A JP2024515301 A JP 2024515301A JP 2023563833 A JP2023563833 A JP 2023563833A JP 2023563833 A JP2023563833 A JP 2023563833A JP 2024515301 A JP2024515301 A JP 2024515301A
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polypeptide
domain
hinge
amino acid
light chain
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JP2024515301A5 (https=
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ゴン，ダンヤン
エスティス，ブラム
ワン，ジュウルン
ガルセス，フェルナンド
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アムジエン・インコーポレーテツド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2023563833A 2021-04-20 2022-04-19 多重特異性及び一価のｉｇｇ分子の会合における鎖対形成の静電ステアリングにおけるバランスのとれた電荷分布 Pending JP2024515301A (ja)

Applications Claiming Priority (3)

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US202163177325P 2021-04-20 2021-04-20
US63/177,325 2021-04-20
PCT/US2022/025340 WO2022225921A1 (en) 2021-04-20 2022-04-19 Balanced charge distribution in electrostatic steering of chain pairing in multi-specific and monovalent igg molecule assembly

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JP2024515301A true JP2024515301A (ja) 2024-04-08
JP2024515301A5 JP2024515301A5 (https=) 2025-04-25

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JP2023563833A Pending JP2024515301A (ja) 2021-04-20 2022-04-19 多重特異性及び一価のｉｇｇ分子の会合における鎖対形成の静電ステアリングにおけるバランスのとれた電荷分布

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US (1) US20240182600A1 (https=)
EP (1) EP4326761A1 (https=)
JP (1) JP2024515301A (https=)
CN (1) CN117651714A (https=)
AU (1) AU2022263406A1 (https=)
CA (1) CA3216559A1 (https=)
MX (1) MX2023012324A (https=)
WO (1) WO2022225921A1 (https=)

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TW202544047A (zh) * 2023-12-21 2025-11-16 美商安進公司 穩定雙細胞異二聚體產生的同源二聚體突變

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EP4326761A1 (en) 2024-02-28
MX2023012324A (es) 2023-10-30
CN117651714A (zh) 2024-03-05
CA3216559A1 (en) 2022-10-27
US20240182600A1 (en) 2024-06-06
WO2022225921A1 (en) 2022-10-27
AU2022263406A1 (en) 2023-10-19

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