CN117651714A - 多特异性和单价IgG分子组装中链配对的静电转向中的平衡电荷分布 - Google Patents

多特异性和单价IgG分子组装中链配对的静电转向中的平衡电荷分布 Download PDF

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Publication number
CN117651714A
CN117651714A CN202280043338.8A CN202280043338A CN117651714A CN 117651714 A CN117651714 A CN 117651714A CN 202280043338 A CN202280043338 A CN 202280043338A CN 117651714 A CN117651714 A CN 117651714A
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CN
China
Prior art keywords
polypeptide
domain
hinge
amino acid
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202280043338.8A
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English (en)
Chinese (zh)
Inventor
宫丹阳
B·埃斯蒂斯
王主伦
F·加尔西斯
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Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CN117651714A publication Critical patent/CN117651714A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN202280043338.8A 2021-04-20 2022-04-19 多特异性和单价IgG分子组装中链配对的静电转向中的平衡电荷分布 Pending CN117651714A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163177325P 2021-04-20 2021-04-20
US63/177325 2021-04-20
PCT/US2022/025340 WO2022225921A1 (en) 2021-04-20 2022-04-19 Balanced charge distribution in electrostatic steering of chain pairing in multi-specific and monovalent igg molecule assembly

Publications (1)

Publication Number Publication Date
CN117651714A true CN117651714A (zh) 2024-03-05

Family

ID=81580206

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280043338.8A Pending CN117651714A (zh) 2021-04-20 2022-04-19 多特异性和单价IgG分子组装中链配对的静电转向中的平衡电荷分布

Country Status (8)

Country Link
US (1) US20240182600A1 (https=)
EP (1) EP4326761A1 (https=)
JP (1) JP2024515301A (https=)
CN (1) CN117651714A (https=)
AU (1) AU2022263406A1 (https=)
CA (1) CA3216559A1 (https=)
MX (1) MX2023012324A (https=)
WO (1) WO2022225921A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202544047A (zh) * 2023-12-21 2025-11-16 美商安進公司 穩定雙細胞異二聚體產生的同源二聚體突變

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Publication number Publication date
EP4326761A1 (en) 2024-02-28
JP2024515301A (ja) 2024-04-08
MX2023012324A (es) 2023-10-30
CA3216559A1 (en) 2022-10-27
US20240182600A1 (en) 2024-06-06
WO2022225921A1 (en) 2022-10-27
AU2022263406A1 (en) 2023-10-19

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