AU2022263406A1 - Balanced charge distribution in electrostatic steering of chain pairing in multi-specific and monovalent igg molecule assembly - Google Patents

Balanced charge distribution in electrostatic steering of chain pairing in multi-specific and monovalent igg molecule assembly Download PDF

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Publication number
AU2022263406A1
AU2022263406A1 AU2022263406A AU2022263406A AU2022263406A1 AU 2022263406 A1 AU2022263406 A1 AU 2022263406A1 AU 2022263406 A AU2022263406 A AU 2022263406A AU 2022263406 A AU2022263406 A AU 2022263406A AU 2022263406 A1 AU2022263406 A1 AU 2022263406A1
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AU
Australia
Prior art keywords
polypeptide
domain
hinge
amino acid
chl
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Pending
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AU2022263406A
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English (en)
Inventor
Bram ESTES
Fernando Garces
Danyang GONG
Zhulun Wang
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Amgen Inc
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Amgen Inc
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Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of AU2022263406A1 publication Critical patent/AU2022263406A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2022263406A 2021-04-20 2022-04-19 Balanced charge distribution in electrostatic steering of chain pairing in multi-specific and monovalent igg molecule assembly Pending AU2022263406A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163177325P 2021-04-20 2021-04-20
US63/177,325 2021-04-20
PCT/US2022/025340 WO2022225921A1 (en) 2021-04-20 2022-04-19 Balanced charge distribution in electrostatic steering of chain pairing in multi-specific and monovalent igg molecule assembly

Publications (1)

Publication Number Publication Date
AU2022263406A1 true AU2022263406A1 (en) 2023-10-19

Family

ID=81580206

Family Applications (1)

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AU2022263406A Pending AU2022263406A1 (en) 2021-04-20 2022-04-19 Balanced charge distribution in electrostatic steering of chain pairing in multi-specific and monovalent igg molecule assembly

Country Status (8)

Country Link
US (1) US20240182600A1 (https=)
EP (1) EP4326761A1 (https=)
JP (1) JP2024515301A (https=)
CN (1) CN117651714A (https=)
AU (1) AU2022263406A1 (https=)
CA (1) CA3216559A1 (https=)
MX (1) MX2023012324A (https=)
WO (1) WO2022225921A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202544047A (zh) * 2023-12-21 2025-11-16 美商安進公司 穩定雙細胞異二聚體產生的同源二聚體突變

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Also Published As

Publication number Publication date
EP4326761A1 (en) 2024-02-28
JP2024515301A (ja) 2024-04-08
MX2023012324A (es) 2023-10-30
CN117651714A (zh) 2024-03-05
CA3216559A1 (en) 2022-10-27
US20240182600A1 (en) 2024-06-06
WO2022225921A1 (en) 2022-10-27

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