CA3216559A1 - Balanced charge distribution in electrostatic steering of chain pairing in multi-specific and monovalent igg molecule assembly - Google Patents

Balanced charge distribution in electrostatic steering of chain pairing in multi-specific and monovalent igg molecule assembly Download PDF

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Publication number
CA3216559A1
CA3216559A1 CA3216559A CA3216559A CA3216559A1 CA 3216559 A1 CA3216559 A1 CA 3216559A1 CA 3216559 A CA3216559 A CA 3216559A CA 3216559 A CA3216559 A CA 3216559A CA 3216559 A1 CA3216559 A1 CA 3216559A1
Authority
CA
Canada
Prior art keywords
polypeptide
domain
hinge
amino acid
immunoglobulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3216559A
Other languages
English (en)
French (fr)
Inventor
Danyang GONG
Bram ESTES
Zhulun Wang
Fernando Garces
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CA3216559A1 publication Critical patent/CA3216559A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA3216559A 2021-04-20 2022-04-19 Balanced charge distribution in electrostatic steering of chain pairing in multi-specific and monovalent igg molecule assembly Pending CA3216559A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163177325P 2021-04-20 2021-04-20
US63/177,325 2021-04-20
PCT/US2022/025340 WO2022225921A1 (en) 2021-04-20 2022-04-19 Balanced charge distribution in electrostatic steering of chain pairing in multi-specific and monovalent igg molecule assembly

Publications (1)

Publication Number Publication Date
CA3216559A1 true CA3216559A1 (en) 2022-10-27

Family

ID=81580206

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3216559A Pending CA3216559A1 (en) 2021-04-20 2022-04-19 Balanced charge distribution in electrostatic steering of chain pairing in multi-specific and monovalent igg molecule assembly

Country Status (8)

Country Link
US (1) US20240182600A1 (https=)
EP (1) EP4326761A1 (https=)
JP (1) JP2024515301A (https=)
CN (1) CN117651714A (https=)
AU (1) AU2022263406A1 (https=)
CA (1) CA3216559A1 (https=)
MX (1) MX2023012324A (https=)
WO (1) WO2022225921A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202544047A (zh) * 2023-12-21 2025-11-16 美商安進公司 穩定雙細胞異二聚體產生的同源二聚體突變

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Also Published As

Publication number Publication date
EP4326761A1 (en) 2024-02-28
JP2024515301A (ja) 2024-04-08
MX2023012324A (es) 2023-10-30
CN117651714A (zh) 2024-03-05
US20240182600A1 (en) 2024-06-06
WO2022225921A1 (en) 2022-10-27
AU2022263406A1 (en) 2023-10-19

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