JP2024509280A - Ｋｒａｓ阻害物質としてのピリドピリミジン誘導体 - Google Patents

Ｋｒａｓ阻害物質としてのピリドピリミジン誘導体 Download PDF

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Publication number
JP2024509280A
JP2024509280A JP2023555330A JP2023555330A JP2024509280A JP 2024509280 A JP2024509280 A JP 2024509280A JP 2023555330 A JP2023555330 A JP 2023555330A JP 2023555330 A JP2023555330 A JP 2023555330A JP 2024509280 A JP2024509280 A JP 2024509280A
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Japan
Prior art keywords
alkyl
compound
kras
compounds
formula
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Pending
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JP2023555330A
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Japanese (ja)
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JP2024509280A5 (enExample
Inventor
ジャン，ドン
ペン，ジロン
ジョン コスタンゾ，マイケル
アラン グリーン，マイケル
ニコラス グレコ，マイケル
ボルグナス，スティーブン
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Beta Pharma Inc
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Beta Pharma Inc
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Publication of JP2024509280A publication Critical patent/JP2024509280A/ja
Publication of JP2024509280A5 publication Critical patent/JP2024509280A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2023555330A 2021-03-10 2022-03-09 Ｋｒａｓ阻害物質としてのピリドピリミジン誘導体 Pending JP2024509280A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163159024P 2021-03-10 2021-03-10
US63/159,024 2021-03-10
PCT/US2022/019449 WO2022192332A1 (en) 2021-03-10 2022-03-09 Pyridopyrimidine derivatives as kras inhibitors

Publications (2)

Publication Number Publication Date
JP2024509280A true JP2024509280A (ja) 2024-02-29
JP2024509280A5 JP2024509280A5 (enExample) 2025-03-17

Family

ID=83228274

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023555330A Pending JP2024509280A (ja) 2021-03-10 2022-03-09 Ｋｒａｓ阻害物質としてのピリドピリミジン誘導体

Country Status (6)

Country Link
US (1) US20240140948A1 (enExample)
EP (1) EP4281457A4 (enExample)
JP (1) JP2024509280A (enExample)
CN (1) CN116964057A (enExample)
AU (1) AU2022234388A1 (enExample)
WO (1) WO2022192332A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250276968A1 (en) * 2022-05-09 2025-09-04 Beta Pharma, Inc. 8- and 6-substituted pyridopyrimidine derivatives as kras inhibitors
AU2023356610A1 (en) * 2022-10-05 2025-04-03 Amgen Inc. Tethered heterocyclic inhibitors of kras g12c mutant proteins and uses thereof
US20260216179A1 (en) * 2022-10-31 2026-07-30 Beta Pharma, Inc. 1,5-naphthyridine derivatives as kras oncoprotein inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113999226A (zh) * 2020-12-22 2022-02-01 上海科州药物研发有限公司 作为kras抑制剂的杂环化合物的制备及其应用方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2863873T3 (es) * 2016-05-18 2021-10-11 Mirati Therapeutics Inc Inhibidores de KRAS G12C
JP2019529484A (ja) * 2016-09-29 2019-10-17 アラクセス ファーマ エルエルシー Ｋｒａｓ ｇ１２ｃ変異体タンパク質の阻害剤
UA127968C2 (uk) * 2017-05-22 2024-02-28 Емджен Інк. Інгібітори g12c kras і способи їх застосування
ES2961253T3 (es) * 2018-08-31 2024-03-11 Mirati Therapeutics Inc Inhibidores de KRas G12C
WO2020146613A1 (en) * 2019-01-10 2020-07-16 Mirati Therapeutics, Inc. Kras g12c inhibitors
CN114615981B (zh) * 2019-08-29 2024-04-12 米拉蒂治疗股份有限公司 Kras g12d抑制剂
WO2022135470A1 (zh) * 2020-12-22 2022-06-30 上海科州药物研发有限公司 作为kras抑制剂的杂环化合物的制备及其应用方法
US20250276968A1 (en) * 2022-05-09 2025-09-04 Beta Pharma, Inc. 8- and 6-substituted pyridopyrimidine derivatives as kras inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113999226A (zh) * 2020-12-22 2022-02-01 上海科州药物研发有限公司 作为kras抑制剂的杂环化合物的制备及其应用方法

Also Published As

Publication number Publication date
WO2022192332A1 (en) 2022-09-15
AU2022234388A1 (en) 2023-10-26
CN116964057A (zh) 2023-10-27
EP4281457A4 (en) 2024-07-31
EP4281457A1 (en) 2023-11-29
US20240140948A1 (en) 2024-05-02

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