JP2024504728A - キメラ抗原受容体(car)構築物およびcar構築物を発現するnk細胞 - Google Patents
キメラ抗原受容体(car)構築物およびcar構築物を発現するnk細胞 Download PDFInfo
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
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- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163141621P | 2021-01-26 | 2021-01-26 | |
| US63/141,621 | 2021-01-26 | ||
| PCT/CN2022/073808 WO2022161355A1 (en) | 2021-01-26 | 2022-01-25 | Chimeric antigen receptor (car) constructs and nk cells expressing car constructs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024504728A true JP2024504728A (ja) | 2024-02-01 |
| JP2024504728A5 JP2024504728A5 (https=) | 2025-01-29 |
| JPWO2022161355A5 JPWO2022161355A5 (https=) | 2025-01-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023545206A Pending JP2024504728A (ja) | 2021-01-26 | 2022-01-25 | キメラ抗原受容体(car)構築物およびcar構築物を発現するnk細胞 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20240115607A1 (https=) |
| EP (1) | EP4284394A1 (https=) |
| JP (1) | JP2024504728A (https=) |
| CN (1) | CN117062611A (https=) |
| WO (1) | WO2022161355A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2020232691B2 (en) | 2019-03-05 | 2023-06-29 | Nkarta, Inc. | CD19-directed chimeric antigen receptors and uses thereof in immunotherapy |
| CN116286660B (zh) * | 2022-12-08 | 2023-10-03 | 全球细胞控股(广州)有限公司 | 一种ipsc-(car)自然杀伤细胞、制备方法及其在肿瘤治疗中的应用 |
| AU2024347771A1 (en) * | 2023-09-25 | 2026-02-19 | Legend Biotech Ireland Limited | Engineered receptors and methods of use thereof |
| WO2025140265A1 (en) * | 2023-12-26 | 2025-07-03 | Wuxi Biologics (Shanghai) Co., Ltd. | Combination of chimeric antigen receptor and dap10 in cell therapy |
| WO2026003135A1 (en) * | 2024-06-27 | 2026-01-02 | Genicity Limited | Engineered lymphocytes expressing interleukin-15 and interleukin-21 and uses thereof |
Citations (8)
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| JP2016174607A (ja) * | 2010-12-09 | 2016-10-06 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペン | 癌を治療するためのキメラ抗原受容体改変t細胞の使用 |
| JP2018500944A (ja) * | 2014-12-29 | 2018-01-18 | ノバルティス アーゲー | キメラ抗原受容体発現細胞の製造法 |
| JP2018505174A (ja) * | 2015-01-29 | 2018-02-22 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | キメラ抗原受容体、組成物及び方法 |
| WO2019226708A1 (en) * | 2018-05-22 | 2019-11-28 | Nantkwest, Inc. | Fc-epsilon car |
| WO2020097164A1 (en) * | 2018-11-06 | 2020-05-14 | Washington University | Chimeric antigen receptor memory-like (carml) nk cells and methods of making and using same |
| WO2020198128A1 (en) * | 2019-03-22 | 2020-10-01 | The Regents Of The University Of California | Switchable chimeric antigen receptor-engineered human natural killer cells |
| US20200308248A1 (en) * | 2019-03-26 | 2020-10-01 | ST Phi Therapeutics | Chimeric Natural Killer Cell Receptors and Method of Using Thereof |
| JP2020536559A (ja) * | 2017-10-12 | 2020-12-17 | アイセル・ジーン・セラピューティクス・エルエルシー | 複数の抗原を標的とするcompoundキメラ抗原受容体(cCAR)の組成物およびその使用方法 |
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- 2022-01-25 JP JP2023545206A patent/JP2024504728A/ja active Pending
- 2022-01-25 WO PCT/CN2022/073808 patent/WO2022161355A1/en not_active Ceased
- 2022-01-25 EP EP22703879.1A patent/EP4284394A1/en active Pending
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| US20240115607A1 (en) | 2024-04-11 |
| WO2022161355A1 (en) | 2022-08-04 |
| CN117062611A (zh) | 2023-11-14 |
| EP4284394A1 (en) | 2023-12-06 |
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