JP2024504636A5 - - Google Patents

Info

Publication number
JP2024504636A5
JP2024504636A5 JP2023542883A JP2023542883A JP2024504636A5 JP 2024504636 A5 JP2024504636 A5 JP 2024504636A5 JP 2023542883 A JP2023542883 A JP 2023542883A JP 2023542883 A JP2023542883 A JP 2023542883A JP 2024504636 A5 JP2024504636 A5 JP 2024504636A5
Authority
JP
Japan
Prior art keywords
composition according
iii
formula
independently
lipidoid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023542883A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024504636A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2022/012786 external-priority patent/WO2022155598A2/en
Publication of JP2024504636A publication Critical patent/JP2024504636A/ja
Publication of JP2024504636A5 publication Critical patent/JP2024504636A5/ja
Pending legal-status Critical Current

Links

JP2023542883A 2021-01-15 2022-01-18 mRNAの標的化送達のための脂質ナノ粒子 Pending JP2024504636A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202163138047P 2021-01-15 2021-01-15
US63/138,047 2021-01-15
US202163251791P 2021-10-04 2021-10-04
US63/251,791 2021-10-04
US202163256811P 2021-10-18 2021-10-18
US63/256,811 2021-10-18
PCT/US2022/012786 WO2022155598A2 (en) 2021-01-15 2022-01-18 Lipid nanoparticles for targeted delivery of mrna

Publications (2)

Publication Number Publication Date
JP2024504636A JP2024504636A (ja) 2024-02-01
JP2024504636A5 true JP2024504636A5 (https=) 2025-01-24

Family

ID=82448614

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023542883A Pending JP2024504636A (ja) 2021-01-15 2022-01-18 mRNAの標的化送達のための脂質ナノ粒子

Country Status (7)

Country Link
US (1) US20250276086A1 (https=)
EP (1) EP4277603A4 (https=)
JP (1) JP2024504636A (https=)
KR (1) KR20240016244A (https=)
AU (1) AU2022208484A1 (https=)
IL (1) IL304464A (https=)
WO (1) WO2022155598A2 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117769428A (zh) * 2021-04-30 2024-03-26 塔夫茨大学信托人 用于治疗疾病和病症的类脂质纳米颗粒
US20250195431A1 (en) * 2022-03-11 2025-06-19 Trustees Of Tufts College Lipid nanoparticles for targeted delivery of mrna
CN116063245B (zh) * 2022-12-05 2024-09-10 南开大学 一种中心可降解的mRNA脂质体纳米粒子及其制备方法和应用
WO2024136309A1 (en) * 2022-12-23 2024-06-27 Green Cross Corporation Ionizable lipid and use thereof
WO2024175550A1 (en) * 2023-02-20 2024-08-29 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for the treatment of atherosclerotic cardiovascular disease
WO2024178136A1 (en) * 2023-02-21 2024-08-29 The Brigham And Women’S Hospital, Inc. Anti-crispr delivery compositions and methods
AU2024279278A1 (en) 2023-05-31 2025-12-18 Capstan Therapeutics, Inc. Lipid nanoparticle formulations and compositions
WO2025006613A1 (en) * 2023-06-27 2025-01-02 Hopewell Therapeutics, Inc. Lipid nanoparticles for cancer immunotherapy
WO2025165999A1 (en) * 2024-01-30 2025-08-07 Trustees Of Tufts College Lipid nanoparticle for targeted delivery

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2859923T3 (es) * 2013-02-28 2021-10-04 Univ Tufts Compuestos de disulfuro para el suministro de agentes farmacéuticos
MX2020007944A (es) * 2018-02-01 2020-11-24 Tufts College Nanocomplejos similares a los lípidos y sus usos.
US20200061211A1 (en) * 2018-08-22 2020-02-27 Blueallele, Llc Methods for delivering gene editing reagents to cells within organs
JP7691742B2 (ja) * 2019-06-04 2025-06-12 トラスティーズ オブ タフツ カレッジ Mrna送達のための合成脂質

Similar Documents

Publication Publication Date Title
JP2024504636A5 (https=)
US5776908A (en) Amphiphilic derivatives of piperazine
JP2024099679A (ja) 層間エステル、チオエステル、ジスルフィドおよび無水部分を含む2,5-ジオキソピペラジン脂質
JP2025175052A5 (https=)
US20240374520A1 (en) Proteolipid vesicles formulated with fusion associated small transmembrane proteins
JP2021501754A5 (https=)
JP2918693B2 (ja) 両親媒性イミダゾリニウム誘導体
WO2023109242A1 (zh) 可离子化脂质化合物在核酸药物递送系统中的应用
JPH07505134A (ja) エアロゾル化注入遺伝子送達による肺のトランスフェクション
JP2026012402A5 (https=)
JPH05508626A (ja) 生物学的活性分子の細胞内配達のための陽イオン脂質
JP2020510072A5 (https=)
JPH09505808A (ja) グアニジンの両親媒性誘導体
JP2022502451A5 (https=)
JP2001510457A (ja) インビボ送達に有効な、脂質―核酸複合体の安定な製剤の調製
US6649780B1 (en) Cationic lipids
CN113710799A (zh) 用于在LNP中使用的编码CAS9的优化mRNA
JP2024540101A5 (https=)
JP2024500158A (ja) 1,2-ジオレオイル-3-トリメチルアンモニウム-プロパン(dotap)脂質ナノ粒子による組織特異的核酸送達
JP2020532546A (ja) 組織特異的送達用のカチオン性脂質組成物
JP2023518944A5 (https=)
JP2025501905A (ja) イオン化脂質、脂質ナノ粒子、及びこれらの使用
Kimura et al. Nano–Bio Interactions: Exploring the Biological Behavior and the Fate of Lipid-Based Gene Delivery Systems: S. Kimura, H. Harashima
WO2024055681A1 (zh) 脂质偶联完全可降解水溶性聚合物的合成及应用
JP2024543272A5 (https=)