JP2024504503A - 脱塩基ヌクレオチドを含有する核酸 - Google Patents

脱塩基ヌクレオチドを含有する核酸 Download PDF

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JP2024504503A
JP2024504503A JP2023546403A JP2023546403A JP2024504503A JP 2024504503 A JP2024504503 A JP 2024504503A JP 2023546403 A JP2023546403 A JP 2023546403A JP 2023546403 A JP2023546403 A JP 2023546403A JP 2024504503 A JP2024504503 A JP 2024504503A
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nucleic acid
nucleotide
nucleotides
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アリ モルタザヴィ、アフマド
マンネラ、ヴィヴィアナ
ジャヤラマン、ムトゥサミー
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イー セラピューティクス パブリック リミテッド カンパニー
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Priority claimed from PCT/EP2022/052070 external-priority patent/WO2022162155A1/en
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    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/30—Chemical structure
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    • C12N2310/35—Nature of the modification
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2023546403A 2021-01-30 2022-01-28 脱塩基ヌクレオチドを含有する核酸 Pending JP2024504503A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202163143805P 2021-01-30 2021-01-30
US63/143,805 2021-01-30
US202163262316P 2021-10-08 2021-10-08
US63/262,316 2021-10-08
US202163271684P 2021-10-25 2021-10-25
US63/271,684 2021-10-25
PCT/EP2022/052070 WO2022162155A1 (en) 2021-01-30 2022-01-28 Nucleic acids containing abasic nucleotides

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JP2024504503A true JP2024504503A (ja) 2024-01-31
JP2024504503A5 JP2024504503A5 (https=) 2025-01-27

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US (1) US20230407311A1 (https=)
JP (1) JP2024504503A (https=)
KR (1) KR20230136644A (https=)
AU (1) AU2022212580A1 (https=)
BR (1) BR112023014443A2 (https=)
CA (1) CA3204331A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3204340A1 (en) 2021-01-30 2022-08-04 Ahmad Ali MORTAZAVI Conjugated oligonucleotide compounds, methods of making and uses thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005518803A (ja) * 2002-02-20 2005-06-30 サーナ・セラピューティクス・インコーポレイテッド 短干渉核酸（ｓｉＮＡ）を用いる遺伝子発現のＲＮＡ干渉媒介性阻害
JP2013516190A (ja) * 2010-01-07 2013-05-13 クォーク ファーマシューティカルズ インコーポレーティッド 非ヌクレオチドオーバーハングを含むオリゴヌクレオチド化合物
JP2015133968A (ja) * 2008-02-11 2015-07-27 アールエックスアイ ファーマシューティカルズ コーポレーション 修飾ＲＮＡｉポリヌクレオチドおよびその使用
WO2019048645A1 (en) * 2017-09-08 2019-03-14 Mina Therapeutics Limited STABILIZED COMPOSITIONS OF SMALL ACTIVATOR RNA (PARNA) FROM CEBPA AND METHODS OF USE
WO2020123410A1 (en) * 2018-12-10 2020-06-18 Amgen Inc. CHEMICALLY-MODIFIED RNAi CONSTRUCTS AND USES THEREOF
JP2020533334A (ja) * 2017-09-11 2020-11-19 アローヘッド ファーマシューティカルズ インコーポレイテッド アポリポタンパク質Ｃ−ＩＩＩ（ＡＰＯＣ３）の発現を阻害するためのＲＮＡｉ剤および組成物

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005518803A (ja) * 2002-02-20 2005-06-30 サーナ・セラピューティクス・インコーポレイテッド 短干渉核酸（ｓｉＮＡ）を用いる遺伝子発現のＲＮＡ干渉媒介性阻害
JP2015133968A (ja) * 2008-02-11 2015-07-27 アールエックスアイ ファーマシューティカルズ コーポレーション 修飾ＲＮＡｉポリヌクレオチドおよびその使用
JP2013516190A (ja) * 2010-01-07 2013-05-13 クォーク ファーマシューティカルズ インコーポレーティッド 非ヌクレオチドオーバーハングを含むオリゴヌクレオチド化合物
WO2019048645A1 (en) * 2017-09-08 2019-03-14 Mina Therapeutics Limited STABILIZED COMPOSITIONS OF SMALL ACTIVATOR RNA (PARNA) FROM CEBPA AND METHODS OF USE
JP2020533334A (ja) * 2017-09-11 2020-11-19 アローヘッド ファーマシューティカルズ インコーポレイテッド アポリポタンパク質Ｃ−ＩＩＩ（ＡＰＯＣ３）の発現を阻害するためのＲＮＡｉ剤および組成物
WO2020123410A1 (en) * 2018-12-10 2020-06-18 Amgen Inc. CHEMICALLY-MODIFIED RNAi CONSTRUCTS AND USES THEREOF

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AU2022212580A1 (en) 2023-07-27
US20230407311A1 (en) 2023-12-21
AU2022212580A9 (en) 2024-09-19
BR112023014443A2 (pt) 2024-01-23
CA3204331A1 (en) 2022-08-04
KR20230136644A (ko) 2023-09-26

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