JP2024503235A - Ｃｄｋ２阻害剤の固体形態 - Google Patents

Ｃｄｋ２阻害剤の固体形態 Download PDF

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Publication number
JP2024503235A
JP2024503235A JP2023537491A JP2023537491A JP2024503235A JP 2024503235 A JP2024503235 A JP 2024503235A JP 2023537491 A JP2023537491 A JP 2023537491A JP 2023537491 A JP2023537491 A JP 2023537491A JP 2024503235 A JP2024503235 A JP 2024503235A
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cancer
ppm
crystalline
values
crystalline form
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JP2023537491A
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Japanese (ja)
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JP2024503235A5 (https=
Inventor
カオ フェンジュアン
フランシス ディボイェス ケヴィン
ヘバーライン マイケル
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ファイザー・インク
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Publication of JP2024503235A publication Critical patent/JP2024503235A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cereal-Derived Products (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2023537491A 2020-12-24 2021-12-21 Ｃｄｋ２阻害剤の固体形態 Pending JP2024503235A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063130530P 2020-12-24 2020-12-24
US63/130,530 2020-12-24
PCT/IB2021/062082 WO2022137106A1 (en) 2020-12-24 2021-12-21 Solid forms of a cdk2 inhibitor

Publications (2)

Publication Number Publication Date
JP2024503235A true JP2024503235A (ja) 2024-01-25
JP2024503235A5 JP2024503235A5 (https=) 2024-11-28

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JP2023537491A Pending JP2024503235A (ja) 2020-12-24 2021-12-21 Ｃｄｋ２阻害剤の固体形態

Country Status (10)

Country Link
US (1) US20240076287A1 (https=)
EP (1) EP4267563A1 (https=)
JP (1) JP2024503235A (https=)
KR (1) KR20230122100A (https=)
CN (1) CN116723837A (https=)
AU (1) AU2021404974B2 (https=)
CA (1) CA3206153A1 (https=)
MX (1) MX2023007699A (https=)
TW (1) TWI823213B (https=)
WO (1) WO2022137106A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240020735A (ko) 2021-05-07 2024-02-15 카이메라 쎄라퓨틱스 인코포레이티드 Cdk2 분해제 및 그 용도
US20250127759A1 (en) * 2021-12-02 2025-04-24 Pfizer Inc. Methods and dosing regimens comprising a cdk2 inhibitor for the treatment of cancer
US20250195475A1 (en) * 2022-01-27 2025-06-19 InventisBio Co., Ltd. Cdk2 inhibitor and preparation method and use thereof
WO2024046443A1 (en) * 2022-09-01 2024-03-07 Nutshell Biotech (Shanghai) Co., Ltd. Macrocyclic compounds as selective cdk inhibitors
WO2025191482A1 (en) 2024-03-15 2025-09-18 Pfizer Inc. Synthesis of (1h-pyrazol-5-yl)cyclopentyl carbamate compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020157652A2 (en) * 2019-01-31 2020-08-06 Pfizer Inc. Cdk2 inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
WO2000035296A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Improved release of medicament active agents from a chewing gum coating

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020157652A2 (en) * 2019-01-31 2020-08-06 Pfizer Inc. Cdk2 inhibitors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Ｃ．Ｇ．ＷＥＲＭＵＴＨ編, 最新 創薬化学 下巻, JPN6014029314, 1999, pages 347 - 365, ISSN: 0005773392 *
厚生省医薬安全局審査管理課長: "医薬品の残留溶媒ガイドラインについて", 医薬審, JPN6014031669, 1998, ISSN: 0005773390 *
平山令明, 有機化合物結晶作製ハンドブック, JPN6014035600, 2008, pages 17 - 23, ISSN: 0005773389 *
芦澤一英, 医薬品の多形現象と晶析の化学, JPN6015027444, 2002, pages 273 - 278, ISSN: 0005773391 *

Also Published As

Publication number Publication date
CA3206153A1 (en) 2022-06-30
MX2023007699A (es) 2023-07-10
AU2021404974A9 (en) 2025-04-10
WO2022137106A1 (en) 2022-06-30
CN116723837A (zh) 2023-09-08
KR20230122100A (ko) 2023-08-22
US20240076287A1 (en) 2024-03-07
TWI823213B (zh) 2023-11-21
AU2021404974B2 (en) 2024-11-28
TW202233606A (zh) 2022-09-01
EP4267563A1 (en) 2023-11-01
AU2021404974A1 (en) 2023-07-06

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