JP2024500354A5 - - Google Patents
Info
- Publication number
- JP2024500354A5 JP2024500354A5 JP2023535392A JP2023535392A JP2024500354A5 JP 2024500354 A5 JP2024500354 A5 JP 2024500354A5 JP 2023535392 A JP2023535392 A JP 2023535392A JP 2023535392 A JP2023535392 A JP 2023535392A JP 2024500354 A5 JP2024500354 A5 JP 2024500354A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- amino acid
- item
- terminus
- domains
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063123915P | 2020-12-10 | 2020-12-10 | |
| US63/123,915 | 2020-12-10 | ||
| PCT/US2021/062951 WO2022125986A1 (en) | 2020-12-10 | 2021-12-10 | Orthogonal mutations for heterodimerization |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024500354A JP2024500354A (ja) | 2024-01-09 |
| JP2024500354A5 true JP2024500354A5 (https=) | 2024-05-30 |
Family
ID=81974005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023535392A Pending JP2024500354A (ja) | 2020-12-10 | 2021-12-10 | ヘテロ二量体化のための直交変異 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US12312418B2 (https=) |
| EP (1) | EP4259194A4 (https=) |
| JP (1) | JP2024500354A (https=) |
| KR (1) | KR20230118612A (https=) |
| CN (1) | CN116867514A (https=) |
| AU (1) | AU2021397322A1 (https=) |
| CA (1) | CA3207821A1 (https=) |
| IL (1) | IL303518A (https=) |
| MX (1) | MX2023006899A (https=) |
| WO (1) | WO2022125986A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023245021A2 (en) * | 2022-06-14 | 2023-12-21 | Invenra Inc. | Multispecific binding agents that target cd25 and/or ctla4 and uses thereof |
| WO2025129132A1 (en) * | 2023-12-14 | 2025-06-19 | Invenra Inc. | Multispecific binding agents that target ctla4 and/or cd25 and uses thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013537416A (ja) * | 2010-08-13 | 2013-10-03 | メディミューン リミテッド | 変異型Ｆｃ領域を含むモノマーポリペプチド及び使用方法 |
| ES2758994T3 (es) * | 2010-11-05 | 2020-05-07 | Zymeworks Inc | Diseño anticuerpo heterodimérico estable con mutaciones en el dominio Fc |
| JP6385357B2 (ja) * | 2012-11-27 | 2018-09-05 | アジュ ユニバーシティー インダストリー−アカデミック コーオペレイション ファウンデーションＡｊｏｕ Ｕｎｉｖｅｒｓｉｔｙ Ｉｎｄｕｓｔｒｙ−Ａｃａｄｅｍｉｃ Ｃｏｏｐｅｒａｔｉｏｎ Ｆｏｕｎｄａｔｉｏｎ | 抗体重鎖不変部位の異種二量体、高効率の形成を誘導するｃｈ３ドメイン変異体対、その作製方法および用途 |
| HK1220465A1 (zh) * | 2013-03-06 | 2017-05-05 | Merrimack Pharmaceuticals, Inc. | 抗c-met串联fc双特异性抗体 |
| WO2016130516A1 (en) * | 2015-02-09 | 2016-08-18 | Research Development Foundation | Engineered immunoglobulin fc polypeptides displaying improved complement activation |
| US10696722B2 (en) * | 2016-08-10 | 2020-06-30 | Ajou University Industry-Academic Cooperation Foundation | Heterodimeric Fc-fused cytokine and pharmaceutical composition comprising the same |
| CN110177805B (zh) * | 2016-10-19 | 2024-04-02 | 英温拉公司 | 抗体构建体 |
| WO2018148447A1 (en) * | 2017-02-08 | 2018-08-16 | Adimab, Llc | Antibody heavy chain variable domains targeting the nkg2d receptor |
| JP7438942B2 (ja) * | 2017-10-30 | 2024-02-27 | エフ． ホフマン－ラ ロシュ アーゲー | 単一特異性抗体から多重特異性抗体をインビボ生成させるための方法 |
| US20210163594A1 (en) * | 2018-04-17 | 2021-06-03 | Invenra Inc. | Binding molecules |
| KR102870868B1 (ko) * | 2018-06-01 | 2025-10-15 | 노파르티스 아게 | Bcma에 대한 결합 분자 및 이의 용도 |
| JP7812230B2 (ja) * | 2019-04-25 | 2026-02-09 | エフ． ホフマン－ラ ロシュ アーゲー | ポリペプチド鎖交換による抗体由来ポリペプチドの生成 |
| AU2021224883A1 (en) * | 2020-02-20 | 2022-09-29 | Invenra Inc. | Bispecific GD2 and B7H2 binding molecules and methods of use |
-
2021
- 2021-12-10 CA CA3207821A patent/CA3207821A1/en active Pending
- 2021-12-10 MX MX2023006899A patent/MX2023006899A/es unknown
- 2021-12-10 KR KR1020237022864A patent/KR20230118612A/ko active Pending
- 2021-12-10 CN CN202180091688.7A patent/CN116867514A/zh active Pending
- 2021-12-10 US US17/548,375 patent/US12312418B2/en active Active
- 2021-12-10 WO PCT/US2021/062951 patent/WO2022125986A1/en not_active Ceased
- 2021-12-10 AU AU2021397322A patent/AU2021397322A1/en active Pending
- 2021-12-10 JP JP2023535392A patent/JP2024500354A/ja active Pending
- 2021-12-10 IL IL303518A patent/IL303518A/en unknown
- 2021-12-10 EP EP21904522.6A patent/EP4259194A4/en active Pending
-
2025
- 2025-04-25 US US19/190,527 patent/US20260078202A1/en active Pending
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