JP2024116245A5 - - Google Patents

Info

Publication number

JP2024116245A5

JP2024116245A5 JP2024091857A JP2024091857A JP2024116245A5 JP 2024116245 A5 JP2024116245 A5 JP 2024116245A5 JP 2024091857 A JP2024091857 A JP 2024091857A JP 2024091857 A JP2024091857 A JP 2024091857A JP 2024116245 A5 JP2024116245 A5 JP 2024116245A5

Authority

JP

Japan

Prior art keywords

composition

ophthalmic composition

patient

eye

subject

Prior art date

2024-06-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 239000000203 mixture Substances 0.000 claims 25
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 8
• 238000000034 method Methods 0.000 claims 7
• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 6
• 108010036949 Cyclosporine Proteins 0.000 claims 6
• 229960001265 ciclosporin Drugs 0.000 claims 6
• 229930182912 cyclosporin Natural products 0.000 claims 6
• 238000010186 staining Methods 0.000 claims 6
• GYDMBTYTWYNRGO-UHFFFAOYSA-N 1,1,1,2,2,3,3,4,4-nonafluorononane Chemical compound CCCCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)F GYDMBTYTWYNRGO-UHFFFAOYSA-N 0.000 claims 5
• GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims 5
• 208000003556 Dry Eye Syndromes Diseases 0.000 claims 4
• 206010013774 Dry eye Diseases 0.000 claims 3
• 230000004489 tear production Effects 0.000 claims 3
• 208000009319 Keratoconjunctivitis Sicca Diseases 0.000 claims 2
• KZMRYBLIGYQPPP-UHFFFAOYSA-M 3-[[4-[(2-chlorophenyl)-[4-[ethyl-[(3-sulfonatophenyl)methyl]azaniumylidene]cyclohexa-2,5-dien-1-ylidene]methyl]-n-ethylanilino]methyl]benzenesulfonate Chemical compound C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)Cl)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 KZMRYBLIGYQPPP-UHFFFAOYSA-M 0.000 claims 1
• 206010061218 Inflammation Diseases 0.000 claims 1
• 208000023715 Ocular surface disease Diseases 0.000 claims 1
• 239000000607 artificial tear Substances 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 230000001629 suppression Effects 0.000 claims 1
• 230000000699 topical effect Effects 0.000 claims 1
• 208000005494 xerophthalmia Diseases 0.000 claims 1