JP2024096334A5 - - Google Patents
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- JP2024096334A5 JP2024096334A5 JP2024074955A JP2024074955A JP2024096334A5 JP 2024096334 A5 JP2024096334 A5 JP 2024096334A5 JP 2024074955 A JP2024074955 A JP 2024074955A JP 2024074955 A JP2024074955 A JP 2024074955A JP 2024096334 A5 JP2024096334 A5 JP 2024096334A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- group
- acid sequence
- sequence selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 49
- 230000002163 immunogen Effects 0.000 claims 43
- 239000002773 nucleotide Substances 0.000 claims 27
- 125000003729 nucleotide group Chemical group 0.000 claims 27
- 239000000203 mixture Substances 0.000 claims 23
- 108020004707 nucleic acids Proteins 0.000 claims 22
- 102000039446 nucleic acids Human genes 0.000 claims 22
- 150000007523 nucleic acids Chemical class 0.000 claims 22
- 239000012634 fragment Substances 0.000 claims 20
- 230000035772 mutation Effects 0.000 claims 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims 9
- 241000579048 Merkel cell polyomavirus Species 0.000 claims 8
- 239000000427 antigen Substances 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 2
- 102000053602 DNA Human genes 0.000 claims 2
- 101710128836 Large T antigen Proteins 0.000 claims 2
- 101710185500 Small t antigen Proteins 0.000 claims 2
- 108091081024 Start codon Proteins 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 238000004520 electroporation Methods 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 231100000590 oncogenic Toxicity 0.000 claims 2
- 230000002246 oncogenic effect Effects 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 230000007170 pathology Effects 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 108091006112 ATPases Proteins 0.000 claims 1
- 102000057290 Adenosine Triphosphatases Human genes 0.000 claims 1
- 102220572734 Cbp/p300-interacting transactivator 1_L91A_mutation Human genes 0.000 claims 1
- 102220572735 Cbp/p300-interacting transactivator 1_M95A_mutation Human genes 0.000 claims 1
- 108020004705 Codon Proteins 0.000 claims 1
- 101150095705 FBXW7 gene Proteins 0.000 claims 1
- 102000004447 HSP40 Heat-Shock Proteins Human genes 0.000 claims 1
- 108010042283 HSP40 Heat-Shock Proteins Proteins 0.000 claims 1
- 101000621540 Homo sapiens Vam6/Vps39-like protein Proteins 0.000 claims 1
- 208000002030 Merkel cell carcinoma Diseases 0.000 claims 1
- 108060004795 Methyltransferase Proteins 0.000 claims 1
- 108010006519 Molecular Chaperones Proteins 0.000 claims 1
- 102000005431 Molecular Chaperones Human genes 0.000 claims 1
- 206010029266 Neuroendocrine carcinoma of the skin Diseases 0.000 claims 1
- 102220520202 Neutrophil cytosol factor 4_K92A_mutation Human genes 0.000 claims 1
- 102220520208 Neutrophil cytosol factor 4_Y94A_mutation Human genes 0.000 claims 1
- 102220503147 Phosphoinositide-3-kinase-interacting protein 1_D93A_mutation Human genes 0.000 claims 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 claims 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 claims 1
- 108020005038 Terminator Codon Proteins 0.000 claims 1
- 102100022962 Vam6/Vps39-like protein Human genes 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 208000017763 cutaneous neuroendocrine carcinoma Diseases 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims 1
- 102200158845 rs41475844 Human genes 0.000 claims 1
- 230000009466 transformation Effects 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862619161P | 2018-01-19 | 2018-01-19 | |
| US62/619,161 | 2018-01-19 | ||
| PCT/US2019/014171 WO2019143921A2 (en) | 2018-01-19 | 2019-01-18 | Large and small t antigens of merkel cell polyomavirus, nucleic acid constructs and vaccines made therefrom, and methods of using same |
| JP2020539735A JP7485604B2 (ja) | 2018-01-19 | 2019-01-18 | メルケル細胞ポリオーマウイルスのラージおよびスモールｔ抗原、それから作製される核酸構築物およびワクチン、ならびにそれを使用する方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020539735A Division JP7485604B2 (ja) | 2018-01-19 | 2019-01-18 | メルケル細胞ポリオーマウイルスのラージおよびスモールｔ抗原、それから作製される核酸構築物およびワクチン、ならびにそれを使用する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024096334A JP2024096334A (ja) | 2024-07-12 |
| JP2024096334A5 true JP2024096334A5 (enExample) | 2024-10-23 |
Family
ID=67302504
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020539735A Active JP7485604B2 (ja) | 2018-01-19 | 2019-01-18 | メルケル細胞ポリオーマウイルスのラージおよびスモールｔ抗原、それから作製される核酸構築物およびワクチン、ならびにそれを使用する方法 |
| JP2024074955A Pending JP2024096334A (ja) | 2018-01-19 | 2024-05-02 | メルケル細胞ポリオーマウイルスのラージおよびスモールｔ抗原、それから作製される核酸構築物およびワクチン、ならびにそれを使用する方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020539735A Active JP7485604B2 (ja) | 2018-01-19 | 2019-01-18 | メルケル細胞ポリオーマウイルスのラージおよびスモールｔ抗原、それから作製される核酸構築物およびワクチン、ならびにそれを使用する方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11524065B2 (enExample) |
| EP (1) | EP3740226A4 (enExample) |
| JP (2) | JP7485604B2 (enExample) |
| KR (1) | KR20200110678A (enExample) |
| CN (2) | CN120514835A (enExample) |
| AU (2) | AU2019210063B2 (enExample) |
| BR (1) | BR112020014632A2 (enExample) |
| CA (1) | CA3088374A1 (enExample) |
| EA (1) | EA202091732A1 (enExample) |
| MX (1) | MX2020007676A (enExample) |
| WO (1) | WO2019143921A2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019210063B2 (en) * | 2018-01-19 | 2025-03-06 | The Wistar Institute Of Anatomy And Biology | Large and small T antigens of merkel cell polyomavirus, nucleic acid constructs and vaccines made therefrom, and methods of using same |
| WO2021247534A2 (en) * | 2020-06-01 | 2021-12-09 | The Broad Institute, Inc. | Compositions and methods for treating merkel cell carcinoma (mcc) using hla class i specific epitopes |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002028165A2 (en) * | 2000-10-04 | 2002-04-11 | The Trustees Of The University Of Pennsylvania | Compositions and methods of using capsid protein from flaviviruses and pestiviruses |
| WO2016073595A1 (en) * | 2014-11-05 | 2016-05-12 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | T cells and dendritic cells for polyomavirus therapy |
| EP3101134A1 (en) * | 2015-06-05 | 2016-12-07 | Apcure SAS | Therapeutic vaccine for treating or preventing merkel cell polyoma virus-associated tumors |
| WO2017060283A1 (en) * | 2015-10-06 | 2017-04-13 | Universität Basel | Specific immunodominant peptide epitopes for polyomavirus vaccine |
| AU2019210063B2 (en) * | 2018-01-19 | 2025-03-06 | The Wistar Institute Of Anatomy And Biology | Large and small T antigens of merkel cell polyomavirus, nucleic acid constructs and vaccines made therefrom, and methods of using same |
-
2019
- 2019-01-18 AU AU2019210063A patent/AU2019210063B2/en active Active
- 2019-01-18 WO PCT/US2019/014171 patent/WO2019143921A2/en not_active Ceased
- 2019-01-18 US US16/962,886 patent/US11524065B2/en active Active
- 2019-01-18 EA EA202091732A patent/EA202091732A1/ru unknown
- 2019-01-18 EP EP19741300.8A patent/EP3740226A4/en not_active Withdrawn
- 2019-01-18 MX MX2020007676A patent/MX2020007676A/es unknown
- 2019-01-18 CN CN202510692710.3A patent/CN120514835A/zh active Pending
- 2019-01-18 CA CA3088374A patent/CA3088374A1/en active Pending
- 2019-01-18 CN CN201980014819.4A patent/CN111801111B/zh active Active
- 2019-01-18 BR BR112020014632-3A patent/BR112020014632A2/pt unknown
- 2019-01-18 JP JP2020539735A patent/JP7485604B2/ja active Active
- 2019-01-18 KR KR1020207023370A patent/KR20200110678A/ko not_active Ceased
-
2022
- 2022-12-12 US US18/064,482 patent/US20230201328A1/en active Pending
-
2024
- 2024-05-02 JP JP2024074955A patent/JP2024096334A/ja active Pending
-
2025
- 2025-06-06 AU AU2025204247A patent/AU2025204247A1/en active Pending
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