JP2024063213A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2024063213A5 JP2024063213A5 JP2024034704A JP2024034704A JP2024063213A5 JP 2024063213 A5 JP2024063213 A5 JP 2024063213A5 JP 2024034704 A JP2024034704 A JP 2024034704A JP 2024034704 A JP2024034704 A JP 2024034704A JP 2024063213 A5 JP2024063213 A5 JP 2024063213A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- seq
- cdr3
- cdr1
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562256841P | 2015-11-18 | 2015-11-18 | |
| US62/256,841 | 2015-11-18 | ||
| US201662335746P | 2016-05-13 | 2016-05-13 | |
| US62/335,746 | 2016-05-13 | ||
| US201662349294P | 2016-06-13 | 2016-06-13 | |
| US62/349,294 | 2016-06-13 | ||
| PCT/EP2016/077973 WO2017085172A2 (en) | 2015-11-18 | 2016-11-17 | Improved serum albumin binders |
| JP2018525755A JP7046804B2 (ja) | 2015-11-18 | 2016-11-17 | 改良された血清アルブミン結合剤 |
| JP2021204262A JP7453206B2 (ja) | 2015-11-18 | 2021-12-16 | 改良された血清アルブミン結合剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021204262A Division JP7453206B2 (ja) | 2015-11-18 | 2021-12-16 | 改良された血清アルブミン結合剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024063213A JP2024063213A (ja) | 2024-05-10 |
| JP2024063213A5 true JP2024063213A5 (https=) | 2024-06-07 |
Family
ID=57326420
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018525755A Active JP7046804B2 (ja) | 2015-11-18 | 2016-11-17 | 改良された血清アルブミン結合剤 |
| JP2021204262A Active JP7453206B2 (ja) | 2015-11-18 | 2021-12-16 | 改良された血清アルブミン結合剤 |
| JP2024034704A Pending JP2024063213A (ja) | 2015-11-18 | 2024-03-07 | 改良された血清アルブミン結合剤 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018525755A Active JP7046804B2 (ja) | 2015-11-18 | 2016-11-17 | 改良された血清アルブミン結合剤 |
| JP2021204262A Active JP7453206B2 (ja) | 2015-11-18 | 2021-12-16 | 改良された血清アルブミン結合剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11332519B2 (https=) |
| EP (1) | EP3377525A2 (https=) |
| JP (3) | JP7046804B2 (https=) |
| CN (3) | CN120535622A (https=) |
| AU (2) | AU2016357460B2 (https=) |
| CA (1) | CA3005488A1 (https=) |
| WO (1) | WO2017085172A2 (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2723769T4 (da) | 2011-06-23 | 2022-09-05 | Ablynx Nv | Teknikker til at forudsige, påvise og reducere uspecifik proteininterferens i assays, som involverer variable immunglobulin-enkeltdomæner |
| KR20250099289A (ko) | 2014-05-16 | 2025-07-01 | 아블린쓰 엔.브이. | 개선된 면역글로불린 가변 도메인 |
| PL3248986T3 (pl) | 2014-05-16 | 2022-05-16 | Ablynx Nv | Domeny zmienne immunoglobuliny |
| RU2018119732A (ru) | 2015-10-30 | 2019-12-03 | Аблинкс Нв | Полипептиды против il-23 |
| CA3043515A1 (en) | 2016-11-16 | 2018-05-24 | Ablynx Nv | T cell recruiting polypeptides capable of binding cd123 and tcr alpha/beta |
| PL3630816T3 (pl) | 2017-05-31 | 2024-08-05 | Boehringer Ingelheim International Gmbh | Polipeptydy antagonizujące sygnalizację wnt w komórkach nowotworowych |
| BR112019025097A2 (pt) | 2017-06-02 | 2020-07-28 | Merck Patent Gmbh | imunoglobulinas de ligação a mmp13 |
| CN111138537B (zh) * | 2018-11-06 | 2021-07-09 | 瑞阳(苏州)生物科技有限公司 | 一种抗人血清白蛋白抗体片段、制备方法和应用 |
| CN111138536B (zh) * | 2018-11-06 | 2021-07-09 | 瑞阳(苏州)生物科技有限公司 | 抗人血清白蛋白单域抗体的制备及其应用 |
| CN112409480B (zh) * | 2019-08-20 | 2024-08-27 | 四川科伦博泰生物医药股份有限公司 | 结合血清白蛋白的蛋白及其用途 |
| PH12022551231A1 (en) * | 2019-12-06 | 2023-07-31 | Ablynx Nv | Polypeptides comprising immunoglobulin single variable domains targeting tnfa and ox40l |
| JP7657797B2 (ja) | 2019-12-06 | 2025-04-07 | アブリンクス エン．ヴェー． | ＴＮＦαおよびＩＬ－２３を標的化する免疫グロブリン単一可変ドメインを含むポリペプチド |
| WO2021116182A1 (en) | 2019-12-09 | 2021-06-17 | Ablynx Nv | Polypeptides comprising immunoglobulin single variable domains targeting il-13 and tslp |
| AU2020403273A1 (en) * | 2019-12-11 | 2022-06-30 | Cullinan Oncology, Inc. | Anti-CD19 antibodies and multi-specific binding proteins |
| CN110988361B (zh) * | 2019-12-13 | 2020-09-18 | 山东民康生物科技有限公司 | 人血清白蛋白去除试剂盒 |
| IL296767A (en) | 2020-03-30 | 2022-11-01 | Ablynx Nv | A method for the production and purification of single variable multivalent immunoglobulin sites |
| MX2023003522A (es) | 2020-09-25 | 2023-04-19 | Ablynx Nv | Polipeptidos que comprenden dominios variables unicos de inmunoglobulina que se dirigen a il-13 y ox40l. |
| KR20230123497A (ko) | 2020-12-18 | 2023-08-23 | 아블린쓰 엔.브이. | IL-6 및 TNF-α를 표적화하는 면역글로불린 단일 가변도메인을 포함하는 폴리펩티드 |
| KR20230122084A (ko) | 2020-12-18 | 2023-08-22 | 아블린쓰 엔.브이. | Tcr 알파/베타 반응성에 기초한 t 세포 동원 폴리펩타이드 |
| KR20230123495A (ko) | 2020-12-18 | 2023-08-23 | 아블린쓰 엔.브이. | 글리피칸-3 및 t세포 수용체를 표적으로 하는 면역글로불린단일 가변 도메인을 포함하는 폴리펩티드 |
| AU2022409733A1 (en) | 2021-12-17 | 2024-08-01 | Ablynx Nv | POLYPEPTIDES COMPRISING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS TARGETING TCRαβ, CD33 AND CD123 |
| KR20250023503A (ko) | 2022-06-14 | 2025-02-18 | 아블린쓰 | T 세포 수용체를 표적화하는 면역글로불린 단일 가변 도메인 |
| MA71603A (fr) | 2022-07-27 | 2025-05-30 | Ablynx Nv | Polypeptides se liant à un épitope spécifique du récepteur fc néonatal |
| EP4605077A1 (en) | 2022-10-18 | 2025-08-27 | Confo Therapeutics N.V. | Amino acid sequences directed against the melanocortin 4 receptor and polypeptides comprising the same for the treatment of mc4r-related diseases and disorders |
| AR131494A1 (es) | 2022-12-23 | 2025-03-26 | Ablynx Nv | Vehículos de conjugación a base de proteína |
| CN120529914A (zh) | 2023-01-09 | 2025-08-22 | 奥德赛治疗股份有限公司 | 抗tnfr2抗原结合蛋白及其用途 |
| JP2026506075A (ja) | 2023-02-17 | 2026-02-20 | アブリンクス エン．ヴェー． | 新生児型ｆｃ受容体に結合するポリペプチド |
| WO2024192065A1 (en) | 2023-03-14 | 2024-09-19 | Odyssey Therapeutics, Inc. | Anti-cd25 antigen-binding proteins and uses thereof |
| CN121511255A (zh) | 2023-05-17 | 2026-02-10 | 奥德赛治疗股份有限公司 | 经修饰的单结构域抗体 |
| KR20260028051A (ko) | 2023-06-22 | 2026-03-03 | 아블린쓰 엔.브이. | 사이토카인의 수용체-활성을 조절하기 위한 키메라 단백질 |
| IL325291A (en) | 2023-06-29 | 2026-02-01 | Odyssey Therapeutics Inc | Anti-TRAILR2 antigen-binding proteins and their uses |
| AR133188A1 (es) | 2023-07-05 | 2025-09-03 | Ablynx Nv | ANTAGONISTAS DE FcRn MEJORADOS PARA EL TRATAMIENTO DE ENFERMEDADES Y TRASTORNOS RELACIONADOS CON IgG |
| WO2025051767A1 (en) | 2023-09-04 | 2025-03-13 | Sanofi | Polypeptides for use in the treatment of glypican-3-expressing tumours |
| US20250129145A1 (en) | 2023-09-22 | 2025-04-24 | Ablynx N.V. | Bi- and multivalent albumin binders |
| WO2025080751A2 (en) | 2023-10-13 | 2025-04-17 | Odyssey Therapeutics, Inc. | Anti-cdh17 antigen-binding proteins and uses thereof |
| AR134267A1 (es) | 2023-11-08 | 2025-12-17 | Sanofi Sa | Degradador lisosómico basado en cd25 y usos del mismo |
| WO2025106915A1 (en) | 2023-11-17 | 2025-05-22 | Sail Biomedicines, Inc. | Circular polyribonucleotides encoding glucagon-like peptide 1 (glp-1) and uses thereof |
| TW202540188A (zh) | 2023-12-01 | 2025-10-16 | 比利時商艾伯霖克斯公司 | 精準活化的多肽 |
| US20250236673A1 (en) | 2023-12-22 | 2025-07-24 | Ablynx N.V. | Protein-based carriers for site-specific amine conjugation |
| TW202543670A (zh) | 2023-12-22 | 2025-11-16 | 比利時商艾伯霖克斯公司 | 用於核內投予之基於蛋白質的接合載劑 |
| WO2025217240A1 (en) | 2024-04-10 | 2025-10-16 | Odyssey Therapeutics, Inc. | Anti-tnfr2 antigen-binding proteins and uses thereof |
| US12459994B2 (en) | 2024-04-12 | 2025-11-04 | Paragon Therapeutics, Inc. | Albumin binding proteins and methods of use |
| WO2025255558A2 (en) | 2024-06-07 | 2025-12-11 | Odyssey Therapeutics, Inc. | Anti-thymic stromal lymphopoietin (tslp) antigen-binding proteins and uses thereof |
| WO2025255435A2 (en) | 2024-06-07 | 2025-12-11 | Odyssey Therapeutics, Inc. | Antigen-binding proteins against serum albumin and uses thereof |
| WO2026006809A1 (en) | 2024-06-27 | 2026-01-02 | Odyssey Therapeutics, Inc. | Multispecific molecules binding tnfr2 and cd25 and uses thereof |
| WO2026006708A2 (en) | 2024-06-27 | 2026-01-02 | Odyssey Therapeutics, Inc. | Anti-cd25 antigen-binding proteins and uses thereof |
| WO2026030375A2 (en) | 2024-07-30 | 2026-02-05 | Genzyme Corporation | Lipid nanoparticles and methods of manufacture and use thereof |
| WO2026052756A1 (en) | 2024-09-05 | 2026-03-12 | Ablynx Nv | Her2 binding immunoglobulin single variable domains, constructs comprising the same and uses thereof |
| WO2026078159A1 (en) | 2024-10-10 | 2026-04-16 | Ablynx Nv | Immune cell engagers and methods comprising the same |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| BR9813276A (pt) | 1997-10-27 | 2000-08-22 | Unilever Nv | Proteìna multivalente de ligação de antìgeno, sequências de nucleotìdeos, vetor de expressão, célula hospedeira, processo para preparação de proteìna multivalente de ligação de antìgeno, e, uso da mesma |
| US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| US20060002935A1 (en) | 2002-06-28 | 2006-01-05 | Domantis Limited | Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor |
| CA2505316C (en) | 2002-11-08 | 2014-08-05 | Ablynx N.V. | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| EP1587838B1 (en) | 2003-01-10 | 2015-04-15 | Ablynx N.V. | Therapeutic polypeptides, homologues thereof, fragments thereof and their use in modulating platelet-mediated aggregation |
| CA2588892A1 (en) | 2004-12-02 | 2006-06-08 | Dormantis Limited | Anti-il-1r1 single domain antibodies and therapeutic uses |
| WO2006122787A1 (en) | 2005-05-18 | 2006-11-23 | Ablynx Nv | Serum albumin binding proteins |
| ES2852423T3 (es) | 2005-05-20 | 2021-09-13 | Ablynx Nv | NanobodiesTM mejorados para el tratamiento de trastornos mediados por agregación |
| CA2632866A1 (en) | 2005-12-01 | 2007-06-07 | Domantis Limited | Noncompetitive domain antibody formats that bind interleukin 1 receptor type 1 |
| EA200801166A1 (ru) | 2005-12-01 | 2008-12-30 | Домантис Лимитед | Форматы конкурентного доменного антитела, которые связываются с рецептором интерлейкина 1 первого типа |
| FR2894741B1 (fr) | 2005-12-08 | 2009-12-04 | Centre Nat Etd Spatiales | Chaine de reception par satellite |
| WO2007085814A1 (en) | 2006-01-24 | 2007-08-02 | Domantis Limited | Fusion proteins that contain natural junctions |
| EP2057191A1 (en) | 2006-08-18 | 2009-05-13 | Ablynx N.V. | Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling |
| CN101796072B (zh) | 2007-05-24 | 2014-09-24 | 埃博灵克斯股份有限公司 | 用于治疗骨疾病和病症的针对rank-l的氨基酸序列以及包括其的多肽 |
| EP2220120A2 (en) | 2007-11-27 | 2010-08-25 | Ablynx N.V. | Amino acid sequences directed against heterodimeric cytokines and/or their receptors and polypeptides comprising the same |
| DE102008023620A1 (de) | 2008-05-15 | 2009-11-19 | Mettler-Toledo (Albstadt) Gmbh | Funktionseinheit mit einer aufrufbaren Funktion und Verfahren zu deren Aufruf |
| NZ589036A (en) | 2008-05-16 | 2012-07-27 | Ablynx Nv | AMINO ACID SEQUENCES DIRECTED AGAINST CXCR4 AND OTHER GPCRs AND COMPOUNDS COMPRISING THE SAME |
| WO2010100135A1 (en) | 2009-03-05 | 2010-09-10 | Ablynx N.V. | Novel antigen binding dimer-complexes, methods of making/avoiding and uses thereof |
| WO2010130832A2 (en) | 2009-05-15 | 2010-11-18 | Ablynx N.V. | Amino acid sequences directed against dickkopf-1 and polypeptides comprising the same for the treatment of diseases and disorders associated with bone loss and/or osteolytic lesions |
| JP2012532620A (ja) | 2009-07-16 | 2012-12-20 | グラクソ グループ リミテッド | 改良型抗血清アルブミン結合単一可変ドメイン |
| DK2723769T4 (da) | 2011-06-23 | 2022-09-05 | Ablynx Nv | Teknikker til at forudsige, påvise og reducere uspecifik proteininterferens i assays, som involverer variable immunglobulin-enkeltdomæner |
| CN106046168A (zh) * | 2011-06-23 | 2016-10-26 | 埃博灵克斯股份有限公司 | 结合血清白蛋白的蛋白 |
| SG2014010482A (en) * | 2011-08-17 | 2014-04-28 | Glaxo Group Ltd | Modified proteins and peptides |
| WO2014087010A1 (en) * | 2012-12-07 | 2014-06-12 | Ablynx N.V. | IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE |
| WO2014111550A1 (en) | 2013-01-17 | 2014-07-24 | Glaxosmithkline Intellectual Property Development Limited | Modified anti-serum albumin binding proteins |
| PL3248986T3 (pl) * | 2014-05-16 | 2022-05-16 | Ablynx Nv | Domeny zmienne immunoglobuliny |
| US10273305B2 (en) * | 2015-04-02 | 2019-04-30 | Ablynx N.V. | Bispecific CXCR4-CD4 polypeptides with potent anti-HIV activity |
| MA43219A (fr) * | 2015-11-10 | 2018-09-19 | Univ Medical Center Hamburg Eppendorf | Polypeptides de liaison d'antigène dirigés contre cd38 |
| MA43260A (fr) * | 2015-11-18 | 2018-09-26 | Merck Sharp & Dohme | Liants pd1 et/ou lag3 |
| CR20180279A (es) * | 2015-11-18 | 2018-08-24 | Merck Sharp & Dohme | Enlazadores de ctla4 |
| US10544222B2 (en) * | 2015-11-18 | 2020-01-28 | Merck Sharp & Dohme Corp. | PD1/CTLA4 binders |
-
2016
- 2016-11-17 CN CN202510665720.8A patent/CN120535622A/zh active Pending
- 2016-11-17 EP EP16797568.9A patent/EP3377525A2/en active Pending
- 2016-11-17 WO PCT/EP2016/077973 patent/WO2017085172A2/en not_active Ceased
- 2016-11-17 CN CN201680079196.5A patent/CN108473564B/zh active Active
- 2016-11-17 CA CA3005488A patent/CA3005488A1/en active Pending
- 2016-11-17 CN CN202210310096.6A patent/CN114605530B/zh active Active
- 2016-11-17 US US15/774,662 patent/US11332519B2/en active Active
- 2016-11-17 AU AU2016357460A patent/AU2016357460B2/en active Active
- 2016-11-17 JP JP2018525755A patent/JP7046804B2/ja active Active
-
2021
- 2021-12-16 JP JP2021204262A patent/JP7453206B2/ja active Active
-
2022
- 2022-04-19 US US17/723,543 patent/US20220380445A1/en active Pending
-
2023
- 2023-09-12 AU AU2023229506A patent/AU2023229506A1/en active Pending
-
2024
- 2024-03-07 JP JP2024034704A patent/JP2024063213A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2024063213A5 (https=) | ||
| JP7453206B2 (ja) | 改良された血清アルブミン結合剤 | |
| JP7840836B2 (ja) | 改善された血清アルブミン結合性免疫グロブリン可変ドメイン | |
| AU2022279374B2 (en) | Improved immunoglobulin variable domains | |
| JP2019503990A5 (https=) | ||
| JP2020506898A5 (https=) | ||
| JP2018537421A5 (https=) | ||
| JP2020515518A5 (https=) | ||
| JP2022502371A5 (https=) | ||
| JP2020500510A5 (https=) | ||
| JPWO2020069028A5 (https=) | ||
| FI3571225T3 (fi) | Parannettuja seerumialbumiinin sitojia | |
| JP2023120208A5 (https=) | ||
| RU2022101604A (ru) | Улучшенные отдельные вариабельные домены иммуноглобулина, связывающиеся с сывороточным альбумином | |
| JP2017519503A5 (https=) | ||
| IL317416A (en) | T cell-recruiting polypeptides capable of binding CD123 and TCR alpha/beta | |
| JP2020532285A5 (https=) | ||
| JP2019506839A5 (https=) | ||
| JP2019503686A5 (https=) | ||
| JP2024023268A5 (https=) | ||
| JP2002531073A (ja) | Ｂ型肝炎ウイルスの表面抗原ｐｒｅ−Ｓ１に対する人間化抗体及びその製造方法 | |
| JPWO2022129560A5 (https=) | ||
| CN116887862A (zh) | 人改性crp特异性中和抗体、以及含有该抗体的药物和抗炎剂 | |
| JPWO2022129572A5 (https=) | ||
| JPWO2023111266A5 (https=) |