JP2024016024A5 - - Google Patents
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- JP2024016024A5 JP2024016024A5 JP2023172391A JP2023172391A JP2024016024A5 JP 2024016024 A5 JP2024016024 A5 JP 2024016024A5 JP 2023172391 A JP2023172391 A JP 2023172391A JP 2023172391 A JP2023172391 A JP 2023172391A JP 2024016024 A5 JP2024016024 A5 JP 2024016024A5
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- JP
- Japan
- Prior art keywords
- chain variable
- variable region
- light chain
- seq
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 25
- 239000000427 antigen Substances 0.000 claims 23
- 102000036639 antigens Human genes 0.000 claims 23
- 108091007433 antigens Proteins 0.000 claims 23
- 239000012634 fragment Substances 0.000 claims 23
- 102000040430 polynucleotide Human genes 0.000 claims 19
- 108091033319 polynucleotide Proteins 0.000 claims 19
- 239000002157 polynucleotide Substances 0.000 claims 19
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 4
- 206010065687 Bone loss Diseases 0.000 claims 3
- 101000709472 Homo sapiens Sialic acid-binding Ig-like lectin 15 Proteins 0.000 claims 3
- 102100034361 Sialic acid-binding Ig-like lectin 15 Human genes 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 210000000988 bone and bone Anatomy 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000000217 endometrial squamous cell carcinoma Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063000566P | 2020-03-27 | 2020-03-27 | |
| US63/000,566 | 2020-03-27 | ||
| JP2022547787A JP7364315B2 (ja) | 2020-03-27 | 2021-03-26 | 抗体結合Ｓｉｇｌｅｃ１５及びその使用 |
| PCT/CN2021/083194 WO2021190622A1 (en) | 2020-03-27 | 2021-03-26 | Antibodies binding siglec15 and uses thereof |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022547787A Division JP7364315B2 (ja) | 2020-03-27 | 2021-03-26 | 抗体結合Ｓｉｇｌｅｃ１５及びその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024016024A JP2024016024A (ja) | 2024-02-06 |
| JP2024016024A5 true JP2024016024A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2024-04-04 |
Family
ID=77891322
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022547787A Active JP7364315B2 (ja) | 2020-03-27 | 2021-03-26 | 抗体結合Ｓｉｇｌｅｃ１５及びその使用 |
| JP2023172391A Pending JP2024016024A (ja) | 2020-03-27 | 2023-10-03 | 抗体結合Ｓｉｇｌｅｃ１５及びその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022547787A Active JP7364315B2 (ja) | 2020-03-27 | 2021-03-26 | 抗体結合Ｓｉｇｌｅｃ１５及びその使用 |
Country Status (13)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115348970B (zh) * | 2020-03-27 | 2023-11-14 | 博奥信生物技术（南京）有限公司 | 结合siglec15的抗体及其用途 |
| WO2023093816A1 (zh) * | 2021-11-25 | 2023-06-01 | 诺纳生物（苏州）有限公司 | 抗Siglec-15抗体及其应用 |
| CN114134183B (zh) * | 2021-12-24 | 2022-12-06 | 广东南模生物科技有限公司 | 一种siglec15基因人源化动物模型的构建方法及应用 |
| CN114807052A (zh) * | 2022-06-07 | 2022-07-29 | 江苏亲科生物研究中心有限公司 | Siglec15单克隆抗体及其制备方法和用途 |
| WO2023241538A1 (en) * | 2022-06-13 | 2023-12-21 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Anti-siglec15 antibodies and uses thereof |
| EP4572772A1 (en) | 2022-08-17 | 2025-06-25 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4604184B2 (ja) * | 2005-07-12 | 2010-12-22 | 独立行政法人産業技術総合研究所 | 新規糖鎖認識蛋白質及びその遺伝子 |
| US8168181B2 (en) | 2006-02-13 | 2012-05-01 | Alethia Biotherapeutics, Inc. | Methods of impairing osteoclast differentiation using antibodies that bind siglec-15 |
| EP2625205A2 (en) * | 2010-10-05 | 2013-08-14 | Daiichi Sankyo Company, Limited | Antibody targeting osteoclast-related protein siglec-15 |
| AU2012306341B2 (en) * | 2011-09-09 | 2017-08-31 | Cambridge Enterprise Limited | Anti-Siglec-15 antibodies and uses thereof |
| TW201345925A (zh) * | 2012-03-30 | 2013-11-16 | Daiichi Sankyo Co Ltd | 新穎抗ｓｉｇｌｅｃ－１５抗體 |
| EA201590247A1 (ru) * | 2012-07-19 | 2015-10-30 | Алетиа Байотерапьютикс Инк. | Антитела к siglec-15 |
| JP2017523148A (ja) * | 2014-06-18 | 2017-08-17 | 第一三共株式会社 | 骨形成不全症の治療に使用するための抗Ｓｉｇｌｅｃ−１５抗体 |
| TWI847955B (zh) * | 2015-11-10 | 2024-07-11 | 耶魯大學 | 用於治療癌症之組成物及方法 |
| KR102644544B1 (ko) | 2016-09-21 | 2024-03-11 | 넥스트큐어 인코포레이티드 | Siglec-15를 위한 항체 및 이의 사용 방법 |
| CN108250296B (zh) * | 2018-01-17 | 2020-07-07 | 长春金赛药业有限责任公司 | 全人源抗人pd-l1单克隆抗体及其应用 |
| EP3847195B1 (en) * | 2018-08-30 | 2025-03-05 | Innovative Cellular Therapeutics Holdings, Ltd. | Chimeric antigen receptor cells for treating solid tumor |
| CN115348970B (zh) * | 2020-03-27 | 2023-11-14 | 博奥信生物技术（南京）有限公司 | 结合siglec15的抗体及其用途 |
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2021
- 2021-03-26 CN CN202180024369.4A patent/CN115348970B/zh active Active
- 2021-03-26 WO PCT/CN2021/083194 patent/WO2021190622A1/en not_active Ceased
- 2021-03-26 PH PH1/2022/552520A patent/PH12022552520A1/en unknown
- 2021-03-26 JP JP2022547787A patent/JP7364315B2/ja active Active
- 2021-03-26 BR BR112022019129A patent/BR112022019129A2/pt unknown
- 2021-03-26 EP EP21774588.4A patent/EP4126938A4/en active Pending
- 2021-03-26 IL IL296736A patent/IL296736B2/en unknown
- 2021-03-26 KR KR1020227030409A patent/KR102651263B1/ko active Active
- 2021-03-26 MX MX2022011951A patent/MX2022011951A/es unknown
- 2021-03-26 AU AU2021240769A patent/AU2021240769B2/en active Active
- 2021-03-26 CA CA3173201A patent/CA3173201A1/en active Pending
-
2022
- 2022-09-25 SA SA522440646A patent/SA522440646B1/ar unknown
- 2022-09-27 US US17/935,815 patent/US11739147B2/en active Active
-
2023
- 2023-05-31 AU AU2023203397A patent/AU2023203397A1/en active Pending
- 2023-06-23 US US18/340,367 patent/US20240002508A1/en active Pending
- 2023-10-03 JP JP2023172391A patent/JP2024016024A/ja active Pending