JP2024009934A5 - - Google Patents
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- JP2024009934A5 JP2024009934A5 JP2023176087A JP2023176087A JP2024009934A5 JP 2024009934 A5 JP2024009934 A5 JP 2024009934A5 JP 2023176087 A JP2023176087 A JP 2023176087A JP 2023176087 A JP2023176087 A JP 2023176087A JP 2024009934 A5 JP2024009934 A5 JP 2024009934A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- nuclease
- genome
- sgrna
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025174888A JP2026012785A (ja) | 2016-12-20 | 2025-10-16 | 細胞ゲノムにおける、相同組換え修復（ｈｄｒ）の効率を上昇させるための方法 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662437042P | 2016-12-20 | 2016-12-20 | |
| US62/437,042 | 2016-12-20 | ||
| JP2019554497A JP2020510443A (ja) | 2016-12-20 | 2017-12-20 | 細胞ゲノムにおける、相同組換え修復（ｈｄｒ）の効率を上昇させるための方法 |
| PCT/US2017/067569 WO2018119060A1 (en) | 2016-12-20 | 2017-12-20 | Methods for increasing the efficiency of homology directed repair (hdr) in the cellular genome |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019554497A Division JP2020510443A (ja) | 2016-12-20 | 2017-12-20 | 細胞ゲノムにおける、相同組換え修復（ｈｄｒ）の効率を上昇させるための方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025174888A Division JP2026012785A (ja) | 2016-12-20 | 2025-10-16 | 細胞ゲノムにおける、相同組換え修復（ｈｄｒ）の効率を上昇させるための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024009934A JP2024009934A (ja) | 2024-01-23 |
| JP2024009934A5 true JP2024009934A5 (https=) | 2024-02-13 |
Family
ID=61006349
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019554497A Pending JP2020510443A (ja) | 2016-12-20 | 2017-12-20 | 細胞ゲノムにおける、相同組換え修復（ｈｄｒ）の効率を上昇させるための方法 |
| JP2023176087A Pending JP2024009934A (ja) | 2016-12-20 | 2023-10-11 | 細胞ゲノムにおける、相同組換え修復（ｈｄｒ）の効率を上昇させるための方法 |
| JP2025174888A Pending JP2026012785A (ja) | 2016-12-20 | 2025-10-16 | 細胞ゲノムにおける、相同組換え修復（ｈｄｒ）の効率を上昇させるための方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019554497A Pending JP2020510443A (ja) | 2016-12-20 | 2017-12-20 | 細胞ゲノムにおける、相同組換え修復（ｈｄｒ）の効率を上昇させるための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025174888A Pending JP2026012785A (ja) | 2016-12-20 | 2025-10-16 | 細胞ゲノムにおける、相同組換え修復（ｈｄｒ）の効率を上昇させるための方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20230193321A1 (https=) |
| EP (2) | EP4286523A3 (https=) |
| JP (3) | JP2020510443A (https=) |
| KR (2) | KR20230162134A (https=) |
| CN (2) | CN110300803B (https=) |
| ES (1) | ES2962711T3 (https=) |
| WO (1) | WO2018119060A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015330699B2 (en) | 2014-10-10 | 2021-12-02 | Editas Medicine, Inc. | Compositions and methods for promoting homology directed repair |
| EP4464338A3 (en) | 2014-11-07 | 2025-02-12 | Editas Medicine, Inc. | Systems for improving crispr/cas-mediated genome-editing |
| EP3353296B1 (en) | 2015-09-24 | 2020-11-04 | Editas Medicine, Inc. | Use of exonucleases to improve crispr/cas-mediated genome editing |
| US11597924B2 (en) | 2016-03-25 | 2023-03-07 | Editas Medicine, Inc. | Genome editing systems comprising repair-modulating enzyme molecules and methods of their use |
| US11236313B2 (en) | 2016-04-13 | 2022-02-01 | Editas Medicine, Inc. | Cas9 fusion molecules, gene editing systems, and methods of use thereof |
| ES2962711T3 (es) | 2016-12-20 | 2024-03-20 | Bristol Myers Squibb Co | Métodos para aumentar la eficacia de la reparación dirigida por homología (HDR) en el genoma celular |
| US11866726B2 (en) | 2017-07-14 | 2024-01-09 | Editas Medicine, Inc. | Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites |
| JP2020537515A (ja) * | 2017-10-03 | 2020-12-24 | ジュノー セラピューティクス インコーポレイテッド | Ｈｐｖ特異的結合分子 |
| WO2020014577A1 (en) * | 2018-07-13 | 2020-01-16 | Allele Biotechnology And Pharmaceuticals, Inc. | Methods of achieving high specificity of genome editing |
| CA3144106A1 (en) | 2019-07-03 | 2021-01-07 | Integrated Dna Technologies, Inc. | Identification, characterization, and quantitation of crispr-introduced double-stranded dna break repairs |
| CN119193713A (zh) | 2019-10-24 | 2024-12-27 | 合成Dna技术公司 | 修饰的双链供体模板 |
| CN111549052A (zh) * | 2020-05-07 | 2020-08-18 | 西南大学 | 一种真核生物CRISPR/Cas全基因组编辑载体文库及构建方法 |
| US20230257768A1 (en) * | 2020-06-12 | 2023-08-17 | National Institute Of Advanced Industrial Science And Technology | Poultry cell in which a gene encoding a protein of interest is knocked-in at egg white protein gene, and method for producing said poultry cell |
| CN111944847A (zh) * | 2020-08-28 | 2020-11-17 | 西北农林科技大学 | 一套等位基因高效替换系统及其建立方法 |
| CN113416730B (zh) * | 2021-07-07 | 2023-04-04 | 中国医学科学院血液病医院(中国医学科学院血液学研究所) | 一种降低细胞因基因编辑产生的大片段删除突变的方法 |
| GB202117455D0 (en) * | 2021-12-02 | 2022-01-19 | Academisch Ziekenhuis Leiden | Method of editing nucleic acid |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4217344A (en) | 1976-06-23 | 1980-08-12 | L'oreal | Compositions containing aqueous dispersions of lipid spheres |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4186183A (en) | 1978-03-29 | 1980-01-29 | The United States Of America As Represented By The Secretary Of The Army | Liposome carriers in chemotherapy of leishmaniasis |
| US4261975A (en) | 1979-09-19 | 1981-04-14 | Merck & Co., Inc. | Viral liposome particle |
| US4485054A (en) | 1982-10-04 | 1984-11-27 | Lipoderm Pharmaceuticals Limited | Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV) |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US4897355A (en) | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US5049386A (en) | 1985-01-07 | 1991-09-17 | Syntex (U.S.A.) Inc. | N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US4946787A (en) | 1985-01-07 | 1990-08-07 | Syntex (U.S.A.) Inc. | N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US4774085A (en) | 1985-07-09 | 1988-09-27 | 501 Board of Regents, Univ. of Texas | Pharmaceutical administration systems containing a mixture of immunomodulators |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| WO1991017424A1 (en) | 1990-05-03 | 1991-11-14 | Vical, Inc. | Intracellular delivery of biologically active substances by means of self-assembling lipid complexes |
| JP4285766B2 (ja) | 1994-03-23 | 2009-06-24 | オハイオ ユニバーシティ | 緻密にした核酸および細胞へのデリバリ |
| US7013219B2 (en) | 1999-01-12 | 2006-03-14 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| US8772008B2 (en) * | 2009-05-18 | 2014-07-08 | Sangamo Biosciences, Inc. | Methods and compositions for increasing nuclease activity |
| US9512444B2 (en) * | 2010-07-23 | 2016-12-06 | Sigma-Aldrich Co. Llc | Genome editing using targeting endonucleases and single-stranded nucleic acids |
| EP3274454B1 (en) | 2015-03-25 | 2021-08-25 | Editas Medicine, Inc. | Crispr/cas-related methods, compositions and components |
| EP3274453B1 (en) * | 2015-03-26 | 2021-01-27 | Editas Medicine, Inc. | Crispr/cas-mediated gene conversion |
| KR102888521B1 (ko) | 2015-04-06 | 2025-11-19 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | Crispr/cas-매개 유전자 조절을 위한 화학적으로 변형된 가이드 rna |
| US10179918B2 (en) | 2015-05-07 | 2019-01-15 | Sangamo Therapeutics, Inc. | Methods and compositions for increasing transgene activity |
| CA2986310A1 (en) * | 2015-05-11 | 2016-11-17 | Editas Medicine, Inc. | Optimized crispr/cas9 systems and methods for gene editing in stem cells |
| CN105734032A (zh) * | 2016-03-25 | 2016-07-06 | 扬州大学 | 一种山羊blg基因定点敲除修饰系统及应用 |
| ES2962711T3 (es) | 2016-12-20 | 2024-03-20 | Bristol Myers Squibb Co | Métodos para aumentar la eficacia de la reparación dirigida por homología (HDR) en el genoma celular |
-
2017
- 2017-12-20 ES ES17832436T patent/ES2962711T3/es active Active
- 2017-12-20 CN CN201780086730.XA patent/CN110300803B/zh active Active
- 2017-12-20 EP EP23188899.1A patent/EP4286523A3/en active Pending
- 2017-12-20 CN CN202410548057.9A patent/CN118460529A/zh active Pending
- 2017-12-20 JP JP2019554497A patent/JP2020510443A/ja active Pending
- 2017-12-20 US US16/471,680 patent/US20230193321A1/en active Pending
- 2017-12-20 KR KR1020237039262A patent/KR20230162134A/ko active Pending
- 2017-12-20 KR KR1020197020845A patent/KR20190095412A/ko not_active Ceased
- 2017-12-20 WO PCT/US2017/067569 patent/WO2018119060A1/en not_active Ceased
- 2017-12-20 EP EP17832436.4A patent/EP3559230B1/en active Active
-
2023
- 2023-10-11 JP JP2023176087A patent/JP2024009934A/ja active Pending
-
2025
- 2025-10-16 JP JP2025174888A patent/JP2026012785A/ja active Pending
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