JP2023553307A - 細胞計数器及び診断装置 - Google Patents

細胞計数器及び診断装置 Download PDF

Info

Publication number
JP2023553307A
JP2023553307A JP2023531107A JP2023531107A JP2023553307A JP 2023553307 A JP2023553307 A JP 2023553307A JP 2023531107 A JP2023531107 A JP 2023531107A JP 2023531107 A JP2023531107 A JP 2023531107A JP 2023553307 A JP2023553307 A JP 2023553307A
Authority
JP
Japan
Prior art keywords
cells
sample
concentration
light
central axis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023531107A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023553307A5 (https=
Inventor
マイケル ゴードン バーカー
カーティス ドブソン
ニシャル ゴヴィンジ－バット
ダレン ケル
ドゥンカン ヘンダーソン
クリストファー ナイト
ニコラス ゴッダード
マーティン スミス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbiosensor Ltd
Original Assignee
Microbiosensor Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbiosensor Ltd filed Critical Microbiosensor Ltd
Publication of JP2023553307A publication Critical patent/JP2023553307A/ja
Publication of JP2023553307A5 publication Critical patent/JP2023553307A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/412—Detecting or monitoring sepsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient; User input means
    • A61B5/746—Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/06—Investigating concentration of particle suspensions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/88—Investigating the presence of flaws or contamination
    • G01N21/90—Investigating the presence of flaws or contamination in a container or its contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0439—White blood cells; Leucocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/06—Investigating concentration of particle suspensions
    • G01N15/075—Investigating concentration of particle suspensions by optical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/016—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G01N2021/052—Tubular type; cavity type; multireflective
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4704—Angular selective
    • G01N2021/4711—Multiangle measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4733—Discriminating different types of scatterers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Optics & Photonics (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Physiology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Materials By The Use Of Optical Means Adapted For Particular Applications (AREA)
  • Optical Measuring Cells (AREA)
JP2023531107A 2020-11-30 2021-11-30 細胞計数器及び診断装置 Pending JP2023553307A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2018831.4 2020-11-30
GB2018831.4A GB2601380A (en) 2020-11-30 2020-11-30 A diagnostic device
PCT/GB2021/053122 WO2022112803A1 (en) 2020-11-30 2021-11-30 A cell counter and diagnostic device

Publications (2)

Publication Number Publication Date
JP2023553307A true JP2023553307A (ja) 2023-12-21
JP2023553307A5 JP2023553307A5 (https=) 2024-12-09

Family

ID=74099817

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023531107A Pending JP2023553307A (ja) 2020-11-30 2021-11-30 細胞計数器及び診断装置

Country Status (12)

Country Link
US (1) US20240035948A1 (https=)
EP (1) EP4078138B1 (https=)
JP (1) JP2023553307A (https=)
KR (1) KR20230112669A (https=)
CN (1) CN116601477A (https=)
AU (1) AU2021386517A1 (https=)
CA (1) CA3202372A1 (https=)
CO (1) CO2023008053A2 (https=)
GB (1) GB2601380A (https=)
IL (1) IL303194A (https=)
MX (1) MX2023006174A (https=)
WO (1) WO2022112803A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202304863D0 (en) * 2023-03-31 2023-05-17 Microbiosensor Ltd A cell counter and diagnostic device
US20260092855A1 (en) * 2024-10-02 2026-04-02 Gambro Lundia Ab Optical determination of white blood cell concentration in fluids

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09239023A (ja) * 1996-03-08 1997-09-16 Terumo Corp 濁度測定機能付き自動腹膜透析装置および腹膜透析用回路
WO2016063364A1 (ja) * 2014-10-22 2016-04-28 株式会社日立ハイテクノロジーズ 細胞計測機構及びそれを有する細胞培養装置並びに細胞計測方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4375334A (en) * 1981-06-18 1983-03-01 The United States Of America As Represented By The Secretary Of The Navy Nephelometer
AU719048B2 (en) * 1995-04-06 2000-05-04 Alfa Laval Agri Ab Method and apparatus for quantitative particle determination in fluids
AT403412B (de) * 1996-04-02 1998-02-25 Avl Verbrennungskraft Messtech Vorrichtung und verfahren zur bestimmung der konzentration von hämoglobinderivaten in einer unverdünnten, unhämolysierten vollblutprobe
SE9804142D0 (sv) * 1998-11-30 1998-11-30 Gambro Ab Method and device for providing a signal
EP1161670B1 (en) * 1999-02-19 2008-12-10 Metron Instruments, Inc. Measurement systems and methods for determining component particle concentrations in a liquid
US7724150B2 (en) * 2007-09-04 2010-05-25 Venturedyne, Ltd. Environmental sensor, particle counting system having an environmental sensor, and methods of operating the same
CN101678162B (zh) * 2008-01-25 2013-10-09 弗雷塞尼斯医疗保健控股公司 包括自清洁流出物室的用于早期腹膜炎检测的设备和方法
DE102011002421A1 (de) * 2011-01-04 2012-07-05 Robert Bosch Gmbh Messgerät zur Messung von Partikelkonzentrationen mittels Streulicht und Verfahren zur Überwachung des Messgerätes
CN102692396B (zh) * 2012-06-14 2014-04-02 南京中医药大学 一种内毒素检测系统及其定量检测方法
EP2869056B1 (en) * 2013-11-05 2020-05-20 Malvern Panalytical Limited Improvements relating to particle characterisation
BR112020011772A2 (pt) * 2017-12-15 2020-11-17 Gastroklenz Inc. sistema de monitoramento do sensor para tratamen-tos com base em cateter permanentes
PL3521810T3 (pl) * 2018-01-31 2020-05-18 Sick Engineering Gmbh Analizator do oznaczania pyłu drobnego
CN109443445B (zh) * 2018-12-18 2023-10-27 苏州同阳科技发展有限公司 一种颗粒物在线监测装置与方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09239023A (ja) * 1996-03-08 1997-09-16 Terumo Corp 濁度測定機能付き自動腹膜透析装置および腹膜透析用回路
WO2016063364A1 (ja) * 2014-10-22 2016-04-28 株式会社日立ハイテクノロジーズ 細胞計測機構及びそれを有する細胞培養装置並びに細胞計測方法

Also Published As

Publication number Publication date
WO2022112803A1 (en) 2022-06-02
IL303194A (en) 2023-07-01
EP4078138A1 (en) 2022-10-26
EP4078138B1 (en) 2024-07-10
CA3202372A1 (en) 2022-06-02
CN116601477A (zh) 2023-08-15
MX2023006174A (es) 2023-07-06
GB2601380A (en) 2022-06-01
GB202018831D0 (en) 2021-01-13
KR20230112669A (ko) 2023-07-27
CO2023008053A2 (es) 2023-06-30
EP4078138C0 (en) 2024-07-10
AU2021386517A9 (en) 2025-03-20
AU2021386517A1 (en) 2023-06-22
US20240035948A1 (en) 2024-02-01

Similar Documents

Publication Publication Date Title
US20220296139A1 (en) Apparatus, system, and methods for urinalysis
CA2501360C (en) Method and device for measurements in blood
JP5266334B2 (ja) 自己洗浄排出物チャンバを含む早期の腹膜炎検出のための装置並びに方法
JP7382341B2 (ja) 赤血球沈降速度及び他の関連パラメータを決定するための装置及び方法
US20110060199A1 (en) Determination of blood pump system performance and sample dilution using a property of fluid being transported
WO2022040601A1 (en) Peritonitis sensors, including peritonitis sensors for automated peritoneal dialysis systems, and associated systems, devices, and methods
JP2023553307A (ja) 細胞計数器及び診断装置
WO2019239980A1 (ja) 体液分析装置
JP5596558B2 (ja) 早期の腹膜炎検出及び体液の生体内検査のための装置
HK40083555B (en) A cell counter and diagnostic device
HK40083555A (en) A cell counter and diagnostic device
WO2024201052A1 (en) A cell counter and diagnostic device
CN102608119B (zh) 管道药液中的运动异物检测装置及方法
Surkova et al. Low-cost optical sensor for real-time blood loss monitoring during transurethral surgery
BR102018073629A2 (pt) Dispositivo e processo para análise da turbidez do líquido peritoneal dialisado
WO2026024810A1 (en) Methods and apparatus for facilitating sample movement and placement within test cards
CN202676605U (zh) 管道药液中的运动异物检测装置
CN121001758A (zh) 用于表征来自腹膜透析患者的流出物的、具有光学和电学传感器的系统
TR2021006530A2 (tr) Girişimsiz (Non-Invaziv) Kan Kalite Parametreleri Ölçüm Sistemi

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20241129

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20241129

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20250728

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20250819

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20251017

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20260317