CN116601477A - 细胞计数器和诊断设备 - Google Patents

细胞计数器和诊断设备 Download PDF

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Publication number
CN116601477A
CN116601477A CN202180080209.1A CN202180080209A CN116601477A CN 116601477 A CN116601477 A CN 116601477A CN 202180080209 A CN202180080209 A CN 202180080209A CN 116601477 A CN116601477 A CN 116601477A
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CN
China
Prior art keywords
light
central axis
cells
concentration
sample
Prior art date
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Pending
Application number
CN202180080209.1A
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English (en)
Chinese (zh)
Inventor
迈克尔·戈登·巴克
柯蒂斯·多布森
尼沙尔·戈文吉·巴特
戴伦·柯尔
邓肯·亨德森
克里斯多夫·克莱特
尼古拉斯·哥达德
马丁·史密斯
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Microbiosensor Ltd
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Microbiosensor Ltd
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Filing date
Publication date
Application filed by Microbiosensor Ltd filed Critical Microbiosensor Ltd
Publication of CN116601477A publication Critical patent/CN116601477A/zh
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/412—Detecting or monitoring sepsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient; User input means
    • A61B5/746—Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/06—Investigating concentration of particle suspensions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/88—Investigating the presence of flaws or contamination
    • G01N21/90—Investigating the presence of flaws or contamination in a container or its contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0439—White blood cells; Leucocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/06—Investigating concentration of particle suspensions
    • G01N15/075—Investigating concentration of particle suspensions by optical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/016—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G01N2021/052—Tubular type; cavity type; multireflective
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4704—Angular selective
    • G01N2021/4711—Multiangle measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4733—Discriminating different types of scatterers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Optics & Photonics (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Physiology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Materials By The Use Of Optical Means Adapted For Particular Applications (AREA)
  • Optical Measuring Cells (AREA)
CN202180080209.1A 2020-11-30 2021-11-30 细胞计数器和诊断设备 Pending CN116601477A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2018831.4 2020-11-30
GB2018831.4A GB2601380A (en) 2020-11-30 2020-11-30 A diagnostic device
PCT/GB2021/053122 WO2022112803A1 (en) 2020-11-30 2021-11-30 A cell counter and diagnostic device

Publications (1)

Publication Number Publication Date
CN116601477A true CN116601477A (zh) 2023-08-15

Family

ID=74099817

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180080209.1A Pending CN116601477A (zh) 2020-11-30 2021-11-30 细胞计数器和诊断设备

Country Status (12)

Country Link
US (1) US20240035948A1 (https=)
EP (1) EP4078138B1 (https=)
JP (1) JP2023553307A (https=)
KR (1) KR20230112669A (https=)
CN (1) CN116601477A (https=)
AU (1) AU2021386517A1 (https=)
CA (1) CA3202372A1 (https=)
CO (1) CO2023008053A2 (https=)
GB (1) GB2601380A (https=)
IL (1) IL303194A (https=)
MX (1) MX2023006174A (https=)
WO (1) WO2022112803A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202304863D0 (en) * 2023-03-31 2023-05-17 Microbiosensor Ltd A cell counter and diagnostic device
US20260092855A1 (en) * 2024-10-02 2026-04-02 Gambro Lundia Ab Optical determination of white blood cell concentration in fluids

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5898487A (en) * 1996-04-02 1999-04-27 Avl Medical Instruments Ag Apparatus and method for determining the concentrations of hemoglobin derivatives
CN102692396A (zh) * 2012-06-14 2012-09-26 南京中医药大学 一种内毒素检测系统及其定量检测方法
CN109443445A (zh) * 2018-12-18 2019-03-08 苏州同阳科技发展有限公司 一种颗粒物在线监测装置与方法
US20190234862A1 (en) * 2018-01-31 2019-08-01 Sick Engineering Gmbh Analysis device for determining particulate matter

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Publication number Priority date Publication date Assignee Title
US4375334A (en) * 1981-06-18 1983-03-01 The United States Of America As Represented By The Secretary Of The Navy Nephelometer
AU719048B2 (en) * 1995-04-06 2000-05-04 Alfa Laval Agri Ab Method and apparatus for quantitative particle determination in fluids
JP3659726B2 (ja) * 1996-03-08 2005-06-15 テルモ株式会社 濁度測定機能付き自動腹膜透析装置および腹膜透析用回路
SE9804142D0 (sv) * 1998-11-30 1998-11-30 Gambro Ab Method and device for providing a signal
EP1161670B1 (en) * 1999-02-19 2008-12-10 Metron Instruments, Inc. Measurement systems and methods for determining component particle concentrations in a liquid
US7724150B2 (en) * 2007-09-04 2010-05-25 Venturedyne, Ltd. Environmental sensor, particle counting system having an environmental sensor, and methods of operating the same
CN101678162B (zh) * 2008-01-25 2013-10-09 弗雷塞尼斯医疗保健控股公司 包括自清洁流出物室的用于早期腹膜炎检测的设备和方法
DE102011002421A1 (de) * 2011-01-04 2012-07-05 Robert Bosch Gmbh Messgerät zur Messung von Partikelkonzentrationen mittels Streulicht und Verfahren zur Überwachung des Messgerätes
EP2869056B1 (en) * 2013-11-05 2020-05-20 Malvern Panalytical Limited Improvements relating to particle characterisation
CN107075437B (zh) * 2014-10-22 2019-12-03 株式会社日立高新技术 细胞测量机构和具有该细胞测量机构的细胞培养装置以及细胞测量方法
BR112020011772A2 (pt) * 2017-12-15 2020-11-17 Gastroklenz Inc. sistema de monitoramento do sensor para tratamen-tos com base em cateter permanentes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5898487A (en) * 1996-04-02 1999-04-27 Avl Medical Instruments Ag Apparatus and method for determining the concentrations of hemoglobin derivatives
CN102692396A (zh) * 2012-06-14 2012-09-26 南京中医药大学 一种内毒素检测系统及其定量检测方法
US20190234862A1 (en) * 2018-01-31 2019-08-01 Sick Engineering Gmbh Analysis device for determining particulate matter
CN109443445A (zh) * 2018-12-18 2019-03-08 苏州同阳科技发展有限公司 一种颗粒物在线监测装置与方法

Also Published As

Publication number Publication date
WO2022112803A1 (en) 2022-06-02
IL303194A (en) 2023-07-01
EP4078138A1 (en) 2022-10-26
EP4078138B1 (en) 2024-07-10
CA3202372A1 (en) 2022-06-02
MX2023006174A (es) 2023-07-06
GB2601380A (en) 2022-06-01
GB202018831D0 (en) 2021-01-13
KR20230112669A (ko) 2023-07-27
CO2023008053A2 (es) 2023-06-30
EP4078138C0 (en) 2024-07-10
JP2023553307A (ja) 2023-12-21
AU2021386517A9 (en) 2025-03-20
AU2021386517A1 (en) 2023-06-22
US20240035948A1 (en) 2024-02-01

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