GB2601380A - A diagnostic device - Google Patents

A diagnostic device Download PDF

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Publication number
GB2601380A
GB2601380A GB2018831.4A GB202018831A GB2601380A GB 2601380 A GB2601380 A GB 2601380A GB 202018831 A GB202018831 A GB 202018831A GB 2601380 A GB2601380 A GB 2601380A
Authority
GB
United Kingdom
Prior art keywords
cells
light
concentration
sample
cuvette
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB2018831.4A
Other languages
English (en)
Other versions
GB202018831D0 (en
Inventor
Gordon Barker Michael
Dobson Curtis
Govindji-Bhatt Nishal
Kell Darren
Henderson Duncan
Knight Christopher
Goddard Nicholas
Smith Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbiosensor Ltd
Original Assignee
Microbiosensor Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbiosensor Ltd filed Critical Microbiosensor Ltd
Priority to GB2018831.4A priority Critical patent/GB2601380A/en
Publication of GB202018831D0 publication Critical patent/GB202018831D0/en
Priority to US18/254,910 priority patent/US20240035948A1/en
Priority to MX2023006174A priority patent/MX2023006174A/es
Priority to IL303194A priority patent/IL303194A/en
Priority to JP2023531107A priority patent/JP2023553307A/ja
Priority to CA3202372A priority patent/CA3202372A1/en
Priority to EP21824634.6A priority patent/EP4078138B1/en
Priority to CN202180080209.1A priority patent/CN116601477A/zh
Priority to AU2021386517A priority patent/AU2021386517A1/en
Priority to KR1020237020874A priority patent/KR20230112669A/ko
Priority to PCT/GB2021/053122 priority patent/WO2022112803A1/en
Publication of GB2601380A publication Critical patent/GB2601380A/en
Priority to CONC2023/0008053A priority patent/CO2023008053A2/es
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/412—Detecting or monitoring sepsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient; User input means
    • A61B5/746—Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/06—Investigating concentration of particle suspensions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/88—Investigating the presence of flaws or contamination
    • G01N21/90—Investigating the presence of flaws or contamination in a container or its contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0439—White blood cells; Leucocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/06—Investigating concentration of particle suspensions
    • G01N15/075—Investigating concentration of particle suspensions by optical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/016—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G01N2021/052—Tubular type; cavity type; multireflective
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4704—Angular selective
    • G01N2021/4711—Multiangle measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4733—Discriminating different types of scatterers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Optics & Photonics (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Physiology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Materials By The Use Of Optical Means Adapted For Particular Applications (AREA)
  • Optical Measuring Cells (AREA)
GB2018831.4A 2020-11-30 2020-11-30 A diagnostic device Withdrawn GB2601380A (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
GB2018831.4A GB2601380A (en) 2020-11-30 2020-11-30 A diagnostic device
PCT/GB2021/053122 WO2022112803A1 (en) 2020-11-30 2021-11-30 A cell counter and diagnostic device
EP21824634.6A EP4078138B1 (en) 2020-11-30 2021-11-30 A cell counter and diagnostic device
MX2023006174A MX2023006174A (es) 2020-11-30 2021-11-30 Contador de células y dispositivo de diagnóstico.
IL303194A IL303194A (en) 2020-11-30 2021-11-30 A cell counter and diagnostic device
JP2023531107A JP2023553307A (ja) 2020-11-30 2021-11-30 細胞計数器及び診断装置
CA3202372A CA3202372A1 (en) 2020-11-30 2021-11-30 A cell counter and diagnostic device
US18/254,910 US20240035948A1 (en) 2020-11-30 2021-11-30 A cell counter and diagnostic device
CN202180080209.1A CN116601477A (zh) 2020-11-30 2021-11-30 细胞计数器和诊断设备
AU2021386517A AU2021386517A1 (en) 2020-11-30 2021-11-30 A cell counter and diagnostic device
KR1020237020874A KR20230112669A (ko) 2020-11-30 2021-11-30 세포 계수기 및 진단 장치
CONC2023/0008053A CO2023008053A2 (es) 2020-11-30 2023-06-21 Contador de células y dispositivo de diagnóstico

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2018831.4A GB2601380A (en) 2020-11-30 2020-11-30 A diagnostic device

Publications (2)

Publication Number Publication Date
GB202018831D0 GB202018831D0 (en) 2021-01-13
GB2601380A true GB2601380A (en) 2022-06-01

Family

ID=74099817

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2018831.4A Withdrawn GB2601380A (en) 2020-11-30 2020-11-30 A diagnostic device

Country Status (12)

Country Link
US (1) US20240035948A1 (https=)
EP (1) EP4078138B1 (https=)
JP (1) JP2023553307A (https=)
KR (1) KR20230112669A (https=)
CN (1) CN116601477A (https=)
AU (1) AU2021386517A1 (https=)
CA (1) CA3202372A1 (https=)
CO (1) CO2023008053A2 (https=)
GB (1) GB2601380A (https=)
IL (1) IL303194A (https=)
MX (1) MX2023006174A (https=)
WO (1) WO2022112803A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202304863D0 (en) * 2023-03-31 2023-05-17 Microbiosensor Ltd A cell counter and diagnostic device
US20260092855A1 (en) * 2024-10-02 2026-04-02 Gambro Lundia Ab Optical determination of white blood cell concentration in fluids

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09239023A (ja) * 1996-03-08 1997-09-16 Terumo Corp 濁度測定機能付き自動腹膜透析装置および腹膜透析用回路
WO2000033053A1 (en) * 1998-11-30 2000-06-08 Gambro Ab Method and device for measuring blood parameters
EP2131892A1 (en) * 2008-01-25 2009-12-16 Fresenius Medical Care Holdings, Inc. Apparatus and methods for early stage peritonitis detection including self-cleaning effluent chamber
WO2019118929A1 (en) * 2017-12-15 2019-06-20 Gastroklenz Inc. Sensor monitoring system for in-dwelling catheter based treatments

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4375334A (en) * 1981-06-18 1983-03-01 The United States Of America As Represented By The Secretary Of The Navy Nephelometer
AU719048B2 (en) * 1995-04-06 2000-05-04 Alfa Laval Agri Ab Method and apparatus for quantitative particle determination in fluids
AT403412B (de) * 1996-04-02 1998-02-25 Avl Verbrennungskraft Messtech Vorrichtung und verfahren zur bestimmung der konzentration von hämoglobinderivaten in einer unverdünnten, unhämolysierten vollblutprobe
EP1161670B1 (en) * 1999-02-19 2008-12-10 Metron Instruments, Inc. Measurement systems and methods for determining component particle concentrations in a liquid
US7724150B2 (en) * 2007-09-04 2010-05-25 Venturedyne, Ltd. Environmental sensor, particle counting system having an environmental sensor, and methods of operating the same
DE102011002421A1 (de) * 2011-01-04 2012-07-05 Robert Bosch Gmbh Messgerät zur Messung von Partikelkonzentrationen mittels Streulicht und Verfahren zur Überwachung des Messgerätes
CN102692396B (zh) * 2012-06-14 2014-04-02 南京中医药大学 一种内毒素检测系统及其定量检测方法
EP2869056B1 (en) * 2013-11-05 2020-05-20 Malvern Panalytical Limited Improvements relating to particle characterisation
CN107075437B (zh) * 2014-10-22 2019-12-03 株式会社日立高新技术 细胞测量机构和具有该细胞测量机构的细胞培养装置以及细胞测量方法
PL3521810T3 (pl) * 2018-01-31 2020-05-18 Sick Engineering Gmbh Analizator do oznaczania pyłu drobnego
CN109443445B (zh) * 2018-12-18 2023-10-27 苏州同阳科技发展有限公司 一种颗粒物在线监测装置与方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09239023A (ja) * 1996-03-08 1997-09-16 Terumo Corp 濁度測定機能付き自動腹膜透析装置および腹膜透析用回路
WO2000033053A1 (en) * 1998-11-30 2000-06-08 Gambro Ab Method and device for measuring blood parameters
EP2131892A1 (en) * 2008-01-25 2009-12-16 Fresenius Medical Care Holdings, Inc. Apparatus and methods for early stage peritonitis detection including self-cleaning effluent chamber
WO2019118929A1 (en) * 2017-12-15 2019-06-20 Gastroklenz Inc. Sensor monitoring system for in-dwelling catheter based treatments

Also Published As

Publication number Publication date
WO2022112803A1 (en) 2022-06-02
IL303194A (en) 2023-07-01
EP4078138A1 (en) 2022-10-26
EP4078138B1 (en) 2024-07-10
CA3202372A1 (en) 2022-06-02
CN116601477A (zh) 2023-08-15
MX2023006174A (es) 2023-07-06
GB202018831D0 (en) 2021-01-13
KR20230112669A (ko) 2023-07-27
CO2023008053A2 (es) 2023-06-30
EP4078138C0 (en) 2024-07-10
JP2023553307A (ja) 2023-12-21
AU2021386517A9 (en) 2025-03-20
AU2021386517A1 (en) 2023-06-22
US20240035948A1 (en) 2024-02-01

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Legal Events

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WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)