|
US5139941A
(en)
|
1985-10-31 |
1992-08-18 |
University Of Florida Research Foundation, Inc. |
AAV transduction vectors
|
|
US4861719A
(en)
|
1986-04-25 |
1989-08-29 |
Fred Hutchinson Cancer Research Center |
DNA constructs for retrovirus packaging cell lines
|
|
US5356806A
(en)
|
1987-06-05 |
1994-10-18 |
The United States Of America As Represented By The Department Of Health And Human Services |
Immortalized human cell lines containing exogenous cytochrome P450
|
|
US4937190A
(en)
|
1987-10-15 |
1990-06-26 |
Wisconsin Alumni Research Foundation |
Translation enhancer
|
|
US6174666B1
(en)
|
1992-03-27 |
2001-01-16 |
The United States Of America As Represented By The Department Of Health And Human Services |
Method of eliminating inhibitory/instability regions from mRNA
|
|
WO1994020517A1
(en)
|
1993-03-08 |
1994-09-15 |
University Of Pittsburgh Of The Commonwealth System Of Higher Education |
Gene transfer for treating a connective tissue of a mammalian host
|
|
US5573764A
(en)
*
|
1994-01-21 |
1996-11-12 |
Genetics Institute, Inc. |
Use of interleukin-12 to prevent graft versus host disease
|
|
DE69520496T2
(de)
|
1994-05-13 |
2001-07-12 |
Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville |
Verfahren und zusammensetzungen als vehikel zur zielgerichtete einbringen von genen
|
|
US6204059B1
(en)
|
1994-06-30 |
2001-03-20 |
University Of Pittsburgh |
AAV capsid vehicles for molecular transfer
|
|
US5527928A
(en)
|
1994-09-30 |
1996-06-18 |
Nantz; Michael H. |
Cationic transport reagents
|
|
US5892071A
(en)
|
1994-09-30 |
1999-04-06 |
The Reagents Of The University Of California |
Cationic transport reagents
|
|
US5962424A
(en)
|
1995-02-21 |
1999-10-05 |
Arch Development Corporation |
Methods and compositions for targeting selectins
|
|
DE69636863T2
(de)
|
1995-02-24 |
2007-11-15 |
Trustees Of The University Of Pennsylvania |
Benutzung von immunmodulatoren zur herstellung von medikamenten zur inhibierung einer immunantwort gegen gleichzeitig verabreichte rekombinante viren
|
|
US5869715A
(en)
|
1995-09-27 |
1999-02-09 |
The Reagents Of The University Of California |
Polyfunctional cationic cytofectins
|
|
US5952221A
(en)
|
1996-03-06 |
1999-09-14 |
Avigen, Inc. |
Adeno-associated virus vectors comprising a first and second nucleic acid sequence
|
|
US5994104A
(en)
|
1996-11-08 |
1999-11-30 |
Royal Free Hospital School Of Medicine |
Interleukin-12 fusion protein
|
|
EP1064392A2
(en)
|
1998-03-16 |
2001-01-03 |
Introgen Therapeutics, Inc. |
Multigene vectors
|
|
WO2000034309A1
(en)
*
|
1998-12-04 |
2000-06-15 |
Dana-Farber Cancer Institute, Inc. |
Cloning and characterization of a cd2 binding protein (cd2bp2)
|
|
US20030035790A1
(en)
|
1999-01-15 |
2003-02-20 |
Shu-Hsia Chen |
Combination therapy for the prevention or treatment of cancer, inflammatory disorders or infectious diseases in a subject
|
|
AU3004700A
(en)
|
1999-02-24 |
2000-09-14 |
University Of Iowa Research Foundation, The |
Methods and compositions for delivery of and specific immune response to nucleotide expression systems
|
|
EP1416971A1
(en)
|
1999-08-16 |
2004-05-12 |
UAB Research Foundation |
Gene transfer imaging and uses thereof
|
|
US6544780B1
(en)
|
2000-06-02 |
2003-04-08 |
Genphar, Inc. |
Adenovirus vector with multiple expression cassettes
|
|
AU2001267058A1
(en)
|
2000-06-09 |
2001-12-17 |
University Of Florida Research Foundation, Inc. |
Aav vector-based compositions and therapeutic uses thereof
|
|
AUPR069500A0
(en)
|
2000-10-11 |
2000-11-09 |
Coster, Douglas John |
Tissue modification
|
|
DK1355566T3
(da)
|
2000-12-18 |
2013-03-04 |
Univ Texas |
Lokal regional kemoterapi og radioterapi ved anvendelse af hydrogel in situ
|
|
CA2441454A1
(en)
|
2001-03-14 |
2002-09-19 |
Avigen, Inc. |
Recombinant adeno-associated virus-mediated gene transfer via retroductal infusion of virions
|
|
CA2440890C
(en)
|
2001-03-27 |
2011-07-19 |
New York University |
Tumor therapy with alphavirus-based and high affinity laminin receptor-targeted vectors
|
|
WO2002089658A2
(en)
|
2001-05-07 |
2002-11-14 |
New York University |
Microvascular free flaps for local or systemic delivery
|
|
EP1390490B1
(en)
|
2001-05-24 |
2009-04-15 |
Genzyme Corporation |
Muscle-specific expression vectors
|
|
US20030003583A1
(en)
|
2001-06-08 |
2003-01-02 |
Raphael Hirsch |
Regulation of transgene expression following AAV transduction
|
|
AU2003221733A1
(en)
|
2002-04-17 |
2003-11-03 |
University Of Florida Research Foundation, Inc. |
Improved raav vectors
|
|
WO2003089011A1
(en)
|
2002-04-19 |
2003-10-30 |
University Of Florida |
rAAV VECTOR-BASED COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF MAMMALIAN DISEASES
|
|
SI1496944T1
(sl)
|
2002-05-01 |
2009-02-28 |
Univ Florida |
Izboljšani sistemi ekspresije RAAV za genetsko modifikacijo specifičnih kapsidnih proteinov
|
|
CA2500523A1
(en)
|
2003-05-01 |
2004-11-18 |
University Of Florida Research Foundation, Inc. |
Vp2-modified raav vector compositions and uses therefor
|
|
CN1798502A
(zh)
|
2003-05-30 |
2006-07-05 |
南佛罗里达大学 |
治疗恶性肿瘤的方法
|
|
US20060193821A1
(en)
*
|
2004-03-05 |
2006-08-31 |
Diener John L |
Aptamers to the human IL-12 cytokine family and their use as autoimmune disease therapeutics
|
|
EP3530736A3
(en)
|
2005-05-09 |
2019-11-06 |
ONO Pharmaceutical Co., Ltd. |
Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics
|
|
EA011619B1
(ru)
*
|
2005-06-20 |
2009-04-28 |
Кадила Хелзкэр Лимитед |
Экспрессионный вектор и способ продуцирования высоких уровней белков
|
|
DE102005055128B4
(de)
|
2005-11-15 |
2015-04-02 |
Universität Rostock |
Viraler Vektor, dessen Verwendung zur Therapie von Leberzellkarzinomen und pharmazeutische Mittel umfassend den Vektor
|
|
US7833754B2
(en)
*
|
2006-01-13 |
2010-11-16 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
IL-12 for expression in mammalian cell
|
|
WO2007090125A2
(en)
|
2006-01-30 |
2007-08-09 |
Introgen Therapeutics, Inc. |
Prognostic factors for anti-hyperproliferative disease gene therapy
|
|
US7919079B2
(en)
*
|
2006-03-31 |
2011-04-05 |
Biosante Pharmaceuticals, Inc. |
Cancer immunotherapy compositions and methods of use
|
|
CA2650375A1
(en)
|
2006-04-26 |
2007-11-08 |
International Aids Vaccine Initiative |
Genetic adjuvants for viral vaccines
|
|
CN101528916B
(zh)
|
2006-04-28 |
2013-09-04 |
宾夕法尼亚大学托管会 |
规模可调的aav生产方法
|
|
DK2623605T3
(en)
|
2007-04-09 |
2019-03-25 |
Univ Florida |
RAAV VECTOR COMPOSITIONS WITH TYROSIN MODIFIED CAPSIDE PROTEINS AND PROCEDURES FOR USE THEREOF
|
|
WO2008128251A1
(en)
|
2007-04-17 |
2008-10-23 |
The Children's Hospital Of Philadelphia |
Humanized viral vectors and methods of use thereof
|
|
KR100911624B1
(ko)
|
2007-05-14 |
2009-08-12 |
연세대학교 산학협력단 |
Ｉｌ－１２ 및 ｉｌ－２３의 효율적인 공동발현 방법
|
|
US20110002961A1
(en)
|
2008-03-03 |
2011-01-06 |
Paul Hermonat Hermonat |
Interleukin 12 paracrine gene delivery enhanced CTL immunotherapy
|
|
MX340972B
(es)
|
2008-10-08 |
2016-08-02 |
Intrexon Corp |
Celulas manipuladas por ingenieria que expresan multiples inmunomoduladores, y uso de las mismas.
|
|
WO2010126766A1
(en)
|
2009-04-30 |
2010-11-04 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Inducible interleukin-12
|
|
JP2014503173A
(ja)
|
2009-11-05 |
2014-02-13 |
プロイェクト、デ、ビオメディシナ、シーマ、ソシエダッド、リミターダ |
制御された発現系
|
|
EP2550359B1
(en)
|
2010-03-23 |
2017-08-09 |
Intrexon Corporation |
Vectors conditionally expressing therapeutic proteins, host cells comprising the vectors, and uses thereof
|
|
WO2011140279A1
(en)
*
|
2010-05-04 |
2011-11-10 |
Wayne State University |
Aav-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells
|
|
US11951157B2
(en)
|
2011-10-11 |
2024-04-09 |
Universitat Zurich |
Methods of treating malignant tumour with IL-12 and anti-PD-1 antibody
|
|
PL3351261T3
(pl)
|
2011-10-11 |
2021-12-06 |
Universität Zürich |
Lek złożony zawierający IL-12 i środek do blokowania cząsteczek hamujących komórki T w terapii nowotworów
|
|
SG10201604810UA
(en)
|
2012-02-07 |
2016-08-30 |
Global Bio Therapeutics Inc |
Compartmentalized method of nucleic acid delivery and compositions and uses thereof
|
|
BR112014020325A2
(pt)
|
2012-02-17 |
2017-08-08 |
Childrens Hospital Philadelphia |
composições de vetor do aav e métodos para a transferência de gene para as células, órgãos e tecidos
|
|
NZ716102A
(en)
|
2013-07-22 |
2021-12-24 |
The Children’S Hospital Of Philadelphia |
Variant aav and compositions, methods and uses for gene transfer to cells, organs and tissues
|
|
EP3054971B1
(en)
*
|
2013-10-11 |
2021-03-10 |
The United States of America, represented by the Secretary, Department of Health and Human Services |
Epstein-barr virus vaccines
|
|
SG11201604781RA
(en)
|
2013-12-18 |
2016-07-28 |
Intrexon Corp |
Single chain il-12 nucleic acids, polypeptids, and uses thereof
|
|
US10307492B2
(en)
*
|
2014-03-11 |
2019-06-04 |
Wayne State University |
Modified MGLUR6 promoter and methods of use
|
|
SG11201609879SA
(en)
*
|
2014-06-18 |
2016-12-29 |
Agency Science Tech & Res |
Novel promoters for high level expression
|
|
CA2966988A1
(en)
*
|
2014-11-06 |
2016-05-12 |
Children's Research Institute, Children's National Medical Center |
Immunotherapeutics for cancer and autoimmune diseases
|
|
SG10201913163PA
(en)
|
2015-12-18 |
2020-03-30 |
Oncosec Medical Inc |
Plasmid constructs for heterologous protein expression and methods of use
|
|
PL3458083T3
(pl)
|
2016-05-18 |
2023-03-13 |
Modernatx, Inc. |
Polinukleotydy kodujące interleukinę-12 (il12) i ich zastosowania
|
|
CA3032669A1
(en)
|
2016-08-01 |
2018-02-08 |
William Jia |
Oncolytic herpes simplex virus vectors expressing immune system-stimulatory molecules
|
|
AU2017331275A1
(en)
*
|
2016-09-23 |
2019-05-16 |
Oncosec Medical Incorporated |
Modulating responses to checkpoint inhibitor therapy
|
|
AU2017337073A1
(en)
|
2016-09-30 |
2019-04-18 |
Baylor College Of Medicine |
Antibody based gene therapy with tissue-directed expression
|
|
CN110267978A
(zh)
|
2016-10-07 |
2019-09-20 |
得克萨斯大学体系董事会 |
用于治疗癌症的表达膜锚定的il-12的t细胞
|
|
CN118718020A
(zh)
|
2016-12-09 |
2024-10-01 |
基因药物株式会社 |
含有表达细胞外基质的降解因子的重组腺病毒的抗癌组合物
|
|
US11938197B2
(en)
|
2017-01-10 |
2024-03-26 |
The Sydney Children's Hospitals Network (Randwick And Westmead (Incorporating The Royal Alexandra Hospital For Children) |
Polynucleotides and vectors for the expression of transgenes
|
|
CA3056211A1
(en)
*
|
2017-03-21 |
2018-09-27 |
Stylianos MICHALAKIS |
Gene therapy for the treatment of cngb1-linked retinitis pigmentosa
|
|
EP3600428A4
(en)
*
|
2017-03-23 |
2020-08-26 |
Dnarx |
SYSTEMS AND METHODS FOR THE EXPRESSION OF NUCLEIC ACIDS IN VIVO
|
|
TWI626309B
(zh)
*
|
2017-03-31 |
2018-06-11 |
國立清華大學 |
大量表現目標蛋白系統及其方法
|
|
JOP20190256A1
(ar)
|
2017-05-12 |
2019-10-28 |
Icahn School Med Mount Sinai |
فيروسات داء نيوكاسل واستخداماتها
|
|
US20200306301A1
(en)
|
2017-07-03 |
2020-10-01 |
Torque Therapeutics, Inc. |
Polynucleotides Encoding Immunostimulatory Fusion Molecules and Uses Thereof
|
|
US20200164008A1
(en)
|
2017-07-17 |
2020-05-28 |
Spark Therapeutics, Inc. |
Apheresis methods and uses
|
|
WO2019123414A1
(en)
|
2017-12-22 |
2019-06-27 |
Straximm Llp |
Engineered viruses expressing cyclic gmp-amp synthase
|
|
WO2019143606A1
(en)
|
2018-01-17 |
2019-07-25 |
Nantbio, Inc. |
Enhanced immunogenicity for gpi-anchored antigens
|
|
EP3781176A4
(en)
|
2018-04-09 |
2022-05-25 |
The Trustees of the University of Pennsylvania |
METHODS AND COMPOSITIONS USING A VIRAL VECTOR FOR THE EXPRESSION OF A TRANSGENE AND AN EFFECTOR
|
|
EP3820537A4
(en)
*
|
2018-07-12 |
2022-04-13 |
Spacecraft Seven, LLC |
GENE THERAPY VECTORS FOR TREATMENT OF DANON DISEASE
|
|
BR112021002639A2
(pt)
|
2018-08-16 |
2021-05-11 |
Musc Foundation For Research Development |
vírus recombinantes do mixoma e usos dos mesmos
|
|
US20220040328A1
(en)
*
|
2018-12-11 |
2022-02-10 |
Oncosec Medical Incorporated |
Multigene construct for immune-modulatory protein expression and methods of use
|
|
TW202045533A
(zh)
|
2019-02-01 |
2020-12-16 |
美國德州系統大學評議委員會 |
用於治療癌症之經修飾il-12 t細胞療法
|
|
WO2021073568A1
(en)
|
2019-10-16 |
2021-04-22 |
Wuxi Apptec (Shanghai) Co., Ltd. |
A novel aav variant
|
|
US20210128710A1
(en)
|
2019-11-04 |
2021-05-06 |
Inovio Pharmaceuticals, Inc. |
Combination therapy to treat brain cancer
|
|
WO2021091560A1
(en)
|
2019-11-07 |
2021-05-14 |
Baylor College Of Medicine |
Oncolytic virotherapy and immunotherapy
|
|
US20240076689A1
(en)
|
2020-05-17 |
2024-03-07 |
Boehringer Ingelheim International Gmbh |
Viral vectors and nucleic acids for regulated gene therapy
|
|
JP7820823B2
(ja)
|
2020-05-27 |
2026-02-26 |
ウニヴェルジテート・チューリッヒ |
骨髄性細胞およびミクログリアにおいて特異的に治療タンパク質を発現するウイルスベクター
|