JP2023547883A - 顆粒球マクロファージコロニー刺激因子変異体 - Google Patents

顆粒球マクロファージコロニー刺激因子変異体 Download PDF

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JP2023547883A
JP2023547883A JP2023525008A JP2023525008A JP2023547883A JP 2023547883 A JP2023547883 A JP 2023547883A JP 2023525008 A JP2023525008 A JP 2023525008A JP 2023525008 A JP2023525008 A JP 2023525008A JP 2023547883 A JP2023547883 A JP 2023547883A
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csf
cell
recombinant human
recombinant protein
recombinant
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Japanese (ja)
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JP2023547883A5 (https=
Inventor
フェルダウス，マイケル
ヨスト，ジェフリー
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パートナー セラピューティクス インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2023525008A 2020-10-26 2021-10-25 顆粒球マクロファージコロニー刺激因子変異体 Pending JP2023547883A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063105425P 2020-10-26 2020-10-26
US63/105,425 2020-10-26
US202163177481P 2021-04-21 2021-04-21
US63/177,481 2021-04-21
PCT/US2021/056413 WO2022093671A1 (en) 2020-10-26 2021-10-25 Granulocyte macrophage-colony stimulating factor mutants

Publications (2)

Publication Number Publication Date
JP2023547883A true JP2023547883A (ja) 2023-11-14
JP2023547883A5 JP2023547883A5 (https=) 2024-11-06

Family

ID=81383210

Family Applications (1)

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JP2023525008A Pending JP2023547883A (ja) 2020-10-26 2021-10-25 顆粒球マクロファージコロニー刺激因子変異体

Country Status (5)

Country Link
US (1) US20240182535A1 (https=)
EP (1) EP4232067A4 (https=)
JP (1) JP2023547883A (https=)
CA (1) CA3196431A1 (https=)
WO (1) WO2022093671A1 (https=)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63301798A (ja) * 1987-01-29 1988-12-08 ザイモジェネティクス，インコーポレイティド コロニー刺激因子誘導体
JPH01502196A (ja) * 1987-02-06 1989-08-03 ジェネテイックス・インスティテュート・インコーポレイテッド 炭水化物含量を低下させたコロニー刺激因子
JPH02152995A (ja) * 1988-07-08 1990-06-12 Sumitomo Chem Co Ltd ヒト顆粒球・マクロファージコロニー刺激因子の分離精製法
JPH03502322A (ja) * 1987-10-30 1991-05-30 イミュネックス・コーポレーション ヒトコロニー形成刺激因子の非グリコシル化類似体
EP0646643A1 (en) * 1993-06-30 1995-04-05 Lucky Ltd. Modified human granulocyte macrophage-colony stimulating factor gene and expression thereof in yeast
JP2001510033A (ja) * 1997-07-14 2001-07-31 ボルダー バイオテクノロジー， インコーポレイテッド 成長ホルモンおよび関連タンパク質の誘導体

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5391485A (en) * 1985-08-06 1995-02-21 Immunex Corporation DNAs encoding analog GM-CSF molecules displaying resistance to proteases which cleave at adjacent dibasic residues
US5032676A (en) * 1986-10-14 1991-07-16 Immunex Corporation Nonglycosylated analogs of human colony stimulating factors
US20080076706A1 (en) * 1997-07-14 2008-03-27 Bolder Biotechnology, Inc. Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof
US20040091995A1 (en) * 2001-06-15 2004-05-13 Jeffrey Schlom Recombinant non-replicating virus expressing gm-csf and uses thereof to enhance immune responses
DE60332358D1 (de) * 2002-09-09 2010-06-10 Hanall Pharmaceutical Co Ltd Protease-resistente modifizierte interferon alpha polypeptide
WO2006079169A1 (en) * 2005-01-25 2006-08-03 Apollo Life Sciences Limited Parameter selected gm-csf, il-3, il-4, il-5 and chimeras thereof for therapeutic and diagnostic purposes
US9320777B2 (en) * 2011-05-13 2016-04-26 Bolder Biotechnology, Inc. Methods and use of growth hormone supergene family protein analogs for treatment of radiation exposure

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63301798A (ja) * 1987-01-29 1988-12-08 ザイモジェネティクス，インコーポレイティド コロニー刺激因子誘導体
JPH01502196A (ja) * 1987-02-06 1989-08-03 ジェネテイックス・インスティテュート・インコーポレイテッド 炭水化物含量を低下させたコロニー刺激因子
JPH03502322A (ja) * 1987-10-30 1991-05-30 イミュネックス・コーポレーション ヒトコロニー形成刺激因子の非グリコシル化類似体
JPH02152995A (ja) * 1988-07-08 1990-06-12 Sumitomo Chem Co Ltd ヒト顆粒球・マクロファージコロニー刺激因子の分離精製法
EP0646643A1 (en) * 1993-06-30 1995-04-05 Lucky Ltd. Modified human granulocyte macrophage-colony stimulating factor gene and expression thereof in yeast
JP2001510033A (ja) * 1997-07-14 2001-07-31 ボルダー バイオテクノロジー， インコーポレイテッド 成長ホルモンおよび関連タンパク質の誘導体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"Partner Therapeutics Announces Initiation of Clinical Trial to Evaluate Leukine (Registerd Trademark", PARTNER THERAPEUTICS WEBSITE, vol. [Retrived on 2025.09.11], JPN6025038586, 28 May 2020 (2020-05-28), ISSN: 0005688168 *

Also Published As

Publication number Publication date
EP4232067A1 (en) 2023-08-30
WO2022093671A1 (en) 2022-05-05
CA3196431A1 (en) 2022-05-05
EP4232067A4 (en) 2024-10-23
WO2022093671A9 (en) 2023-04-20
US20240182535A1 (en) 2024-06-06

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